Hanna Winter
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View article: Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis
Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis Open
Aims This study investigated whether TBX18, a transcription factor known for its critical roles in cardiovascular and urogenital development, but never previously studied in the context of the aorta, contributes to the normal development a…
View article: PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition Open
Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, ‘synthetic’ SMCs—defined by migration, proliferation and extracellular matrix production—accumulate …
View article: Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes
Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes Open
peer reviewed
View article: The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis Open
Cyclooxygenase-2 (COX-2) has an established role in inflammation and its inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) is clinically efficacious 1,2 . However, placebo-controlled trials of COX-2 inhibitors have revealed a ca…
View article: PRDM16 controls smooth muscle cell fate in atherosclerosis
PRDM16 controls smooth muscle cell fate in atherosclerosis Open
Summary Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli 1–3 . In atherosclerosis, these phenotypically modulated …
View article: PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis Open
The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions. In the present study, we observed increased expression of the mechanosensitive calcium channel Piezo1 transcript in…
View article: PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis Open
The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions. In the present study, we observed increased expression of the mechanosensitive calcium channel Piezo1 transcript in…
View article: Current and future genomic applications for surgeons
Current and future genomic applications for surgeons Open
Genomics is a crucial part of managing surgical disease. This review focuses on some of the genomic advances that are available now and looks to the future of their application in surgical practice. Whole-genome sequencing enables unbiased…
View article: Human Macrophage Long Intergenic Noncoding RNA, <i>SIMALR</i> , Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1)
Human Macrophage Long Intergenic Noncoding RNA, <i>SIMALR</i> , Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1) Open
Background: Long noncoding RNAs (lncRNAs) have emerged as novel regulators of macrophage biology and inflammatory cardiovascular diseases. However, studies focused on lncRNAs in human macrophage subtypes, particularly human lncRNAs that ar…
View article: Targeting long non-coding RNA<i>NUDT6</i>enhances smooth muscle cell survival and limits vascular disease progression
Targeting long non-coding RNA<i>NUDT6</i>enhances smooth muscle cell survival and limits vascular disease progression Open
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our …
View article: The circular RNA Ataxia-telangiectasia mutated (<i>cATM</i>) regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
The circular RNA Ataxia-telangiectasia mutated (<i>cATM</i>) regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms Open
An abdominal aortic aneurysm (AAA) is a pathological widening of the aortic wall characterized by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and local inflammation. This condition is often asymptomatic until rupt…
View article: Targeting PIEZO1 refines macrophage function in atherosclerosis
Targeting PIEZO1 refines macrophage function in atherosclerosis Open
The increasing prevalence of global atherosclerosis and its complications demand efforts to discover novel targets for therapeutic interventions. In the present study, we identified increased expression of the mechanosensitive calcium chan…
View article: LMO7 regulates smooth muscle cell cholesterol esterification to influence plaque stability
LMO7 regulates smooth muscle cell cholesterol esterification to influence plaque stability Open
Smooth muscle cells (SMC) can undergo distinct fate transitions that influence atherosclerotic plaque phenotype: SMC make up the protective fibrous cap that prevents plaque rupture, but can also transdifferentiate to a destabilizing pro-in…
View article: Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes Open
Red blood cells (RBC) act as mediators of vascular injury in type 2 diabetes mellitus (T2DM). miR-210 plays a protective role in cardiovascular homeostasis and is decreased in whole blood of T2DM mice. We hypothesized that downregulation o…
View article: Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization Open
BACKGROUND Long noncoding RNAs (lncRNAs) are important regulators of biological processes involved in vascular tissue homeostasis and disease development. The present study assessed the functional contribution of the lncRNA myocardial infa…
View article: Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility Open
Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi-tyrosine kinase inhibitor, in limiting experimenta…
View article: Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis
Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis Open
Inflammation plays a pivotal role in the chronicity of atherosclerotic lesion development and progression. Myeloid cells are involved in all stages of atherosclerosis development: they contribute in early phases to endothelial dysfunction …