Hannah A. Cunningham
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View article: 1283 SLEEPoVER Protocol: A Fully Remote, Multimodal Sleep Phenotyping Package to Benchmark Disease Progression and Response to Therapy
1283 SLEEPoVER Protocol: A Fully Remote, Multimodal Sleep Phenotyping Package to Benchmark Disease Progression and Response to Therapy Open
Introduction Previous work supports sleep disturbances as a benchmark of disease progression. To understand this relationship between sleep and health, efforts are emerging to observe sleep in clinical populations and to test sleep therapi…
View article: 1290 Amino Acid Supplementation Improves Sleep in Older Adults with Traumatic Brain Injury at Risk for Neurodegeneration
1290 Amino Acid Supplementation Improves Sleep in Older Adults with Traumatic Brain Injury at Risk for Neurodegeneration Open
Introduction Older adults with a history of traumatic brain injury (TBI) are more likely to experience chronic sleep disturbances and cognitive impairments, elevating their risk of future neurodegeneration. Interventions to mitigate sleep …
View article: 1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury
1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury Open
Introduction Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to i…
View article: Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post‐traumatic stress disorder: an early potential window into autonomic dysfunction?
Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post‐traumatic stress disorder: an early potential window into autonomic dysfunction? Open
Summary Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury and post‐traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD‐re…
View article: SmART-TBI: A fully remote protocol for a randomized placebo-controlled double-blinded clinical trial for a dietary supplement to improve sleep in Veterans
SmART-TBI: A fully remote protocol for a randomized placebo-controlled double-blinded clinical trial for a dietary supplement to improve sleep in Veterans Open
Traumatic brain injury (TBI) is associated with chronic sleep disturbances and cognitive impairment, with limited effective therapeutic strategies. Our previous work showed dietary supplementation with branched chain amino acids (BCAAs; is…
View article: Morning sympathetic activity after evening binge alcohol consumption
Morning sympathetic activity after evening binge alcohol consumption Open
Chronic binge alcohol consumption is associated with future cardiovascular disease (CVD) risk in both men and women. In addition, binge alcohol consumption is known to disrupt normal sleep quality during the early morning hours, coinciding…
View article: Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans
Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans Open
Prior longitudinal work suggests that blood pressure (BP) reactivity to the cold pressor test (CPT) helps predict hypertension; yet the impact of age and sex on hemodynamic and neural responsiveness to CPT remains equivocal. Forty-three yo…
View article: Supplemental table 3.docx
Supplemental table 3.docx Open
Systolic arterial pressure, DAP, MAP and HR declined (time, p<0.01) similarly for older men and women and younger men and women (group × time, p>0.05, supplemental Table 3) during the 3min recovery from the CPT. MSNA burst incidence…
View article: Sympathetic Neural Responses to Acute Thermal Sensations
Sympathetic Neural Responses to Acute Thermal Sensations Open
The influence of thermal stimuli on the sympathetic nervous system is variable and largely depends on the change in temperature and timing of the stimuli. Core temperature changes yield increased muscle sympathetic nerve activity (MSNA) wh…
View article: 0069 Spectral Analyses of Slow Wave Sleep and Rapid Eye Movement Sleep are Associated with Changes in Continuous Nocturnal Blood Pressure
0069 Spectral Analyses of Slow Wave Sleep and Rapid Eye Movement Sleep are Associated with Changes in Continuous Nocturnal Blood Pressure Open
Introduction\nSlow wave (SWS) and rapid eye movement (REM) sleep are both associated with dynamic changes in nocturnal blood pressure (BP). Specifically, SWS is often associated with the greatest reductions of nocturnal BP, while episodic …
View article: 0220 Total Sleep Deprivation Decreases Cardiac Vagal Activity
0220 Total Sleep Deprivation Decreases Cardiac Vagal Activity Open
Introduction Acute 24-hour total sleep deprivation (TSD) elicits a consistent hypertensive response in both men and women. In contrast, divergent sympathetic neural responses to TSD have been reported in men and women, with greater sympath…
View article: 0223 Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Older Adults
0223 Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Older Adults Open
Introduction\nOur laboratory has previously reported an augmented pain response to 24-hour total sleep deprivation (TSD) in young men and women. Because aging is associated with a greater prevalence of chronic pain and diminished sleep qua…