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View article: Genomic and Serologic Characterization of Enterovirus A71 Brainstem Encephalitis
Genomic and Serologic Characterization of Enterovirus A71 Brainstem Encephalitis Open
View article: Association of protective behaviors with SARS-CoV-2 infection: results from a longitudinal cohort study of adults in the San Francisco Bay Area
Association of protective behaviors with SARS-CoV-2 infection: results from a longitudinal cohort study of adults in the San Francisco Bay Area Open
Focusing on protecting people who cannot work from home could help prevent infections during future waves of COVID-19, or future pandemics from respiratory viruses. This focus must be balanced with the known importance of directing resourc…
View article: Association of Protective Behaviors with Sars-Cov-2 Infection: Results from a Longitudinal Cohort Study of Adults in the San Francisco Bay Area
Association of Protective Behaviors with Sars-Cov-2 Infection: Results from a Longitudinal Cohort Study of Adults in the San Francisco Bay Area Open
View article: <scp>ZSCAN1</scp> Autoantibodies Are Associated with Pediatric Paraneoplastic <scp>ROHHAD</scp>
<span>ZSCAN1</span> Autoantibodies Are Associated with Pediatric Paraneoplastic <span>ROHHAD</span> Open
Objective Rapid‐onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), is a severe pediatric disorder of uncertain etiology resulting in hypothalamic dysfunction and frequent sudden death. Freque…
View article: Incidence and Prevalence of Coronavirus Disease 2019 Within a Healthcare Worker Cohort During the First Year of the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic
Incidence and Prevalence of Coronavirus Disease 2019 Within a Healthcare Worker Cohort During the First Year of the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Open
Background Preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2_ infections in healthcare workers (HCWs) is critical for healthcare delivery. We aimed to estimate and characterize the prevalence and incidence of coronavir…
View article: Race-ethnicity and COVID-19 Vaccination Beliefs and Intentions: A Cross-Sectional Study among the General Population in the San Francisco Bay Area
Race-ethnicity and COVID-19 Vaccination Beliefs and Intentions: A Cross-Sectional Study among the General Population in the San Francisco Bay Area Open
Objective: The study was designed to compare intentions to receive COVID-19 vaccination by race–ethnicity, to identify beliefs that may mediate the association between race–ethnicity and intention to receive the vaccine and to identify the…
View article: Design of a population-based longitudinal cohort study of SARS-CoV-2 incidence and prevalence among adults in the San Francisco Bay Area
Design of a population-based longitudinal cohort study of SARS-CoV-2 incidence and prevalence among adults in the San Francisco Bay Area Open
Our stratified random sampling design will allow us to recruit a robust general population cohort of adults to determine the incidence of SARS-CoV-2 infection. Identifying risk strata was unique to the design and will help ensure precise e…
View article: Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis
Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis Open
View article: Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid
Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid Open
This case-control study showed that CSF mNGS, which has low specimen volume requirements, does not require the preservation of cell integrity, and was orginally developed to diagnose neurologic infections, can also detect genetic evidence …
View article: High Completion of COVID-19 Vaccination Among Health Care Workers Despite Initial Self-Reported Vaccine Reluctance
High Completion of COVID-19 Vaccination Among Health Care Workers Despite Initial Self-Reported Vaccine Reluctance Open
View article: Autoimmune profiling suggests paraneoplastic etiology in pediatric ROHHAD
Autoimmune profiling suggests paraneoplastic etiology in pediatric ROHHAD Open
ROHHAD ( R apid-onset O besity with H ypothalamic Dysfunction, H ypoventilation and A utonomic D ysregulation) is a rare, yet severe pediatric disorder resulting in hypothalamic dysfunction and frequent sudden death. Genetic and other inve…
View article: Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Open
Importance Malignant neoplasms of the central nervous system (CNS) are frequently not detected by cerebrospinal fluid (CSF) flow cytometry or cytology, and clinical phenotypes can overlap with inflammatory meningoencephalitis. Objective To…
View article: Race-ethnicity and Perceptional Determinants of COVID-19 Vaccination Intentions: A Cross-sectional Study Among Health Workers and the General Population in the San Francisco Bay Area
Race-ethnicity and Perceptional Determinants of COVID-19 Vaccination Intentions: A Cross-sectional Study Among Health Workers and the General Population in the San Francisco Bay Area Open
Objective To compare intention to receive COVID-19 vaccination by race-ethnicity, to identify perceptional factors that may mediate the association between race-ethnicity and intention to receive the vaccine, and to identify the demographi…
View article: Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Open
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Wei Gu, MD, PhD1,2*, Andreas M. Rauschecker, MD, PhD3, Elaine Hsu, BS1, Kelsey C. Zorn, BS4, Yasemin Sucu, BS1, …
View article: Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Open
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Wei Gu1,2*, Andreas M. Rauschecker3, Elaine Hsu1, Kelsey C. Zorn4, Yasemin Sucu1, Scot Federman1, All…
View article: Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Open
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid Wei Gu, MD, PhD1,2*, Andreas M. Rauschecker, MD, PhD3, Elaine Hsu, BS1, Kelsey C. Zorn, BS4, Yasemin Sucu, BS1, …
View article: Healthcare personnel knowledge, motivations, concerns and intentions regarding COVID-19 vaccines: a cross-sectional survey
Healthcare personnel knowledge, motivations, concerns and intentions regarding COVID-19 vaccines: a cross-sectional survey Open
Background Healthcare personnel (HCP) are prioritized for earliest SARS-CoV-2 vaccine administration, yet relatively few data exist on HCP’s knowledge, motivations, concerns, and intentions regarding COVID-19 vaccines. Methods We conducted…
View article: Executive functions in agenesis of the corpus callosum: Working memory and sustained attention in the BTBR inbred mouse strain
Executive functions in agenesis of the corpus callosum: Working memory and sustained attention in the BTBR inbred mouse strain Open
Introduction Agenesis of the corpus callosum (AgCC) is characterized by the congenital partial or complete absence of the corpus callosum. Several strains of mice have been reported to carry AgCC, with the BTBR T + Itpr3 tf /J (BTBR) inbre…
View article: Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids Open
View article: Author response for "Executive functions in agenesis of the corpus callosum: Working memory and sustained attention in the BTBR inbred mouse strain"
Author response for "Executive functions in agenesis of the corpus callosum: Working memory and sustained attention in the BTBR inbred mouse strain" Open
View article: Genomic and serologic characterization of enterovirus A71 brainstem encephalitis
Genomic and serologic characterization of enterovirus A71 brainstem encephalitis Open
mNGS with VirScan significantly increased the CNS detection of EVs relative to qRT-PCR, and the latter generated an antigenic profile of the acute EV-A71 immune response. Genomic analysis confirmed the close relation of the outbreak EV-A71…
View article: Exploratory analysis of the potential for advanced diagnostic testing to reduce healthcare expenditures of patients hospitalized with meningitis or encephalitis
Exploratory analysis of the potential for advanced diagnostic testing to reduce healthcare expenditures of patients hospitalized with meningitis or encephalitis Open
Inpatient expenditures for patients hospitalized with meningitis or encephalitis were substantial and varied widely. Patient subgroups who had high healthcare expenditures could be identified early in their stay, raising the potential for …
View article: Pan-viral serology implicates enteroviruses in acute flaccid myelitis
Pan-viral serology implicates enteroviruses in acute flaccid myelitis Open
Since 2012, the United States of America has experienced a biennial spike in pediatric acute flaccid myelitis (AFM)1-6. Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely…
View article: LB14. Cerebrospinal Fluid Profiling of the Human Host Response Reveals Species-Specific Enterovirus Biosignatures in Acute Flaccid Myelitis Cases
LB14. Cerebrospinal Fluid Profiling of the Human Host Response Reveals Species-Specific Enterovirus Biosignatures in Acute Flaccid Myelitis Cases Open
Background Since 2014 there have been global biennial outbreaks of acute flaccid myelitis (AFM), a rare but severe “polio-like” illness of as yet-unknown etiology primarily affecting children. Enteroviruses (EVs),, especially EV-D68 and EV…
View article: Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis
Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis Open
OBJECTIVE:To identify molecular correlates of primary angiitis of the CNS (PACNS) through proteomic analysis of CSF from a biopsy-proven patient cohort. METHODS:Using mass spectrometry, we quantitatively compared the CSF proteome of patien…
View article: Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis Open
A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to ide…
View article: Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis Open
Routine microbiologic testing is often insufficient to detect all neuroinvasive pathogens. In this study, metagenomic NGS of CSF obtained from patients with meningitis or encephalitis improved diagnosis of neurologic infections and provide…
View article: Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis
Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis Open
Background Since 2014, the United States has experienced a biennial spike in pediatric acute flaccid myelitis (AFM). Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in c…
View article: Clinicopathology conference: 41‐year‐old woman with chronic relapsing meningitis
Clinicopathology conference: 41‐year‐old woman with chronic relapsing meningitis Open
A 41-year-old woman was seen at the National Institutes of Health (NIH) Neuroimmunology Clinic in 2017 for recurrent episodes of fever, neck stiffness, and back and leg pain. In 2002, at age 26 years, she had several episodes of back and n…
View article: 2563. Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Meningitis and Encephalitis
2563. Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Meningitis and Encephalitis Open
Background Metagenomic next-generation sequencing (mNGS) of CSF can identify nearly all pathogens in a single test. We previously validated a CSF mNGS assay in a licensed clinical laboratory. To date, the utility of mNGS for infectious dis…