Hannah Botfield
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View article: A Systematic Review and Meta‐Analysis of the Role of Peripheral Inflammation in Delirium
A Systematic Review and Meta‐Analysis of the Role of Peripheral Inflammation in Delirium Open
Introduction The pathophysiology of delirium is poorly understood, but the importance of inflammation is widely accepted. The objective was to investigate whether changes in the peripheral immune system have been associated with the develo…
View article: NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity
NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity Open
Doxorubicin (DOX) is an effective anticancer therapeutic but exhibits dose-dependent, potentially life-threatening cardiotoxicity. The specific mechanisms driving this cardiotoxicity are not fully understood but can include the induction o…
View article: Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke
Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke Open
1. Abstract Haemorrhagic stroke is a devastating condition characterised by vessel rupture and free blood within the brain parenchyma or cerebrospinal fluid (CSF) filled spaces. Across the major subtypes of haemorrhagic stroke (subarachnoi…
View article: Systematic Review of the Differential Effects of TGF‐β1 in Ischemic and Hemorrhagic Preclinical Stroke Models
Systematic Review of the Differential Effects of TGF‐β1 in Ischemic and Hemorrhagic Preclinical Stroke Models Open
Background Stroke is a leading cause of death, with patients often experiencing significant disability. Stroke is classified as ischemic, caused by the occlusion of a blood vessel leading to reduction in cerebral blood flow, or hemorrhagic…
View article: Understanding Factors Contributing to Glaucoma in Populations of African Descent
Understanding Factors Contributing to Glaucoma in Populations of African Descent Open
Glaucoma is the leading cause of irreversible blindness globally, with the commonest subtype being primary open angle glaucoma (POAG). POAG is characterised by an increase in intraocular pressure (IOP), optic nerve damage and irreversible …
View article: The double-edged sword of transforming growth factor β 1: a systematic review of pre-clinical stroke models
The double-edged sword of transforming growth factor β 1: a systematic review of pre-clinical stroke models Open
Stroke is a leading cause of death, with those that survive often suffering significant disability. Strokes are classified as ischemic, occlusion of a blood vessel leading to reduction in cerebral blood flow, or hemorrhagic, the rupture of…
View article: Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, β-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was scr…
View article: Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, β-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was scr…
View article: Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 10 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 11 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension
Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension Open
BACKGROUNDIdiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease of metabolic dysregulation, androgen excess, and an increased risk …
View article: 11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension Open
Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic dise…