Hannah M. Burgess
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View article: The divide between us: internet access among people with and without disabilities in the post-pandemic era
The divide between us: internet access among people with and without disabilities in the post-pandemic era Open
The COVID-19 pandemic highlighted the importance of internet access across various aspects of life, from remote work and online education to healthcare services and social connections. As we transition to a post-pandemic era, a pressing ne…
View article: The divide between us: internet access among people with and without disabilities in the post-pandemic era
The divide between us: internet access among people with and without disabilities in the post-pandemic era Open
The COVID-19 pandemic highlighted the importance of internet access across\nvarious aspects of life, from remote work and online education to healthcare\nservices and social connections. As we transition to a post-pandemic era, a\npressing…
View article: State Department of Health’s Equitable Funding Allocation Methodology to Address COVID-19 Health Disparities Among High-Risk and Underserved Populations
State Department of Health’s Equitable Funding Allocation Methodology to Address COVID-19 Health Disparities Among High-Risk and Underserved Populations Open
The Washington State Department of Health developed an equitable funding allocation methodology incorporating quantitative and qualitative decision-making components. We describe the methodology and an implementation evaluation performed b…
View article: Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study Open
Mindfulness witnessed a substantial popularity surge in the past decade, especially as digitally self-administered interventions became available at relatively low costs. Yet, it is uncertain whether they effectively help reduce stress. In…
View article: Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study Open
Mindfulness witnessed a significant popularity surge in the past decade, especially as digitally self-administered interventions became available at relatively low costs. Yet, it is uncertain whether they effectively help reduce stress. In…
View article: An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress
An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress Open
Regulated loading of eIF3-bound 40S ribosomes on capped mRNA is generally dependent upon the translation initiation factor eIF4E; however, mRNA translation often proceeds during physiological stress, such as virus infection, when eIF4E ava…
View article: Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing
Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing Open
The mRNA 5’ cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is ti…
View article: Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells Open
With their categorical requirement for host ribosomes to translate mRNA, viruses provide a wealth of genetically tractable models to investigate how gene expression is remodeled post-transcriptionally by infection-triggered biological stre…
View article: Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing
Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing Open
The mRNA 5’ cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is ti…
View article: Platelets amplify endotheliopathy in COVID-19
Platelets amplify endotheliopathy in COVID-19 Open
Platelet-derived MRP8/14 amplifies endotheliopathy in COVID-19.
View article: Targeting the m<sup>6</sup>A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Targeting the m<sup>6</sup>A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication Open
N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of m 6 A by the nuclear RNA methyltransferase METTL3 occurs cotranscriptio…
View article: Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS Open
In response to virus-induced shutoff host protein synthesis, dynamic aggregates containing mRNA, RNA-binding proteins and translation factors termed stress granules (SGs) often accumulate within the cytoplasm. SGs typically form following …
View article: Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus Open
Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5'-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are mar…
View article: Evolutionary clash between myxoma virus and rabbit PKR in Australia
Evolutionary clash between myxoma virus and rabbit PKR in Australia Open
The success of a virus in defeating or evading cell-intrinsic immune responses contributes to its virulence, pathogenesis, and host range. A central tenet of virology holds that virus and host coevolve as each adapts to survive. Rarely, ho…