Hannah E. Beatty
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View article: Ryanodine receptor 2–mediated calcium leak is associated with increased glyoxalase I in the aging brain
Ryanodine receptor 2–mediated calcium leak is associated with increased glyoxalase I in the aging brain Open
Alzheimer disease (AD) is characterized by plaques and tangles, including calcium dysregulation and glycated products produced by reactive carbonyl compounds. AD brains have increased glyoxalase I (GLO1), a major scavenger of inflammatory …
View article: Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib Open
Background The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This rando…
View article: Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement
Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement Open
Within 72 hours of aSAH, proinflammatory cytokines can be detected at higher concentrations in CSF than in plasma, and at higher concentrations in aSAH patients compared to controls. Early concentrations of certain pro-inflammatory cytokin…
View article: Single-Cell Temporal Atlas of Myeloid Cells in the Live Haemorrhagic Brain
Single-Cell Temporal Atlas of Myeloid Cells in the Live Haemorrhagic Brain Open
CNS-resident microglia and recruited myeloid cells populate the haematoma in intracerebral haemorrhage (ICH), but the contribution of these cell populations to injury and repair has been controversial. To better characterise myeloid cell c…
View article: Characterization of CSF inflammatory markers after hemorrhagic stroke and their relationship to disease severity
Characterization of CSF inflammatory markers after hemorrhagic stroke and their relationship to disease severity Open
Background The inflammatory response within the central nervous system is a key driver of secondary brain injury after hemorrhagic stroke, both in patients with intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage (aSAH). …
View article: Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial Open
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized rando…
View article: Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain
Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain Open
Background and Purpose: Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, and tissue repair after injury. We have previousl…
View article: Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu Open
Intracerebral hemorrhage (ICH) is a devastating form of stroke with a high mortality rate and few treatment options. Discovery of therapeutic interventions has been slow given the challenges associated with studying acute injury in the hum…
View article: Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage Open
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
View article: Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu Open
Intracerebral hemorrhage (ICH) is a devastating form of stroke with a high mortality rate and few treatment options. Discovery of therapeutic interventions has been slow given the challenges associated with studying acute injury, particula…
View article: High-Quality Draft Genome Sequences of Eight Bacteria Isolated from Fungus Gardens Grown by Trachymyrmex septentrionalis Ants
High-Quality Draft Genome Sequences of Eight Bacteria Isolated from Fungus Gardens Grown by Trachymyrmex septentrionalis Ants Open
For their food source, Trachymyrmex septentrionalis ants raise symbiotic fungus gardens that contain bacteria whose functions are poorly understood. Here, we report the genome sequences of eight bacteria isolated from these fungus gardens …
View article: Characterizing Cultivable Bacteria from Trachymyrmex septentrionalis Fungus Gardens
Characterizing Cultivable Bacteria from Trachymyrmex septentrionalis Fungus Gardens Open
The relationship between the fungus-growing ant Trachymyrmex septentrionalis, its symbiotic cultivar fungus, and the transient and residential community of microorganisms is a diverse and complex symbiosis that has evolved over space and t…
View article: Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage
Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage Open
Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute to recovery after …