Hannah E. Maier
YOU?
Author Swipe
View article: Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections
Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections Open
Vaccination and prior infection elicit neutralizing antibodies targeting SARS-CoV-2, yet the quantitative relationship between serum antibodies and infection risk against viral variants remains uncertain, particularly in underrepresented r…
View article: 1<sup>st</sup>, 2<sup>nd</sup>, and 3<sup>rd</sup>+ SARS-CoV-2 infections: associations of prior infections with protection and severity
1<sup>st</sup>, 2<sup>nd</sup>, and 3<sup>rd</sup>+ SARS-CoV-2 infections: associations of prior infections with protection and severity Open
Since the emergence of the antigenically distinct Omicron variant, SARS-CoV-2 reinfections have increased and are common. Yet, as we approach endemicity, the frequency, severity, and consequences of reinfections remain poorly understood. U…
View article: Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections
Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections Open
Background Vaccination and prior infection elicit neutralizing antibodies targeting SARS-CoV-2, yet the quantitative relationship between serum antibodies and infection risk against viral variants remains uncertain, particularly in underre…
View article: Anti-Neuraminidase Antibodies Reduce the Susceptibility to and Infectivity of Influenza A/H3N2 Virus
Anti-Neuraminidase Antibodies Reduce the Susceptibility to and Infectivity of Influenza A/H3N2 Virus Open
Immune responses against neuraminidase (NA) are of great interest for developing more robust influenza vaccines, but the role of anti-NA antibodies on influenza infectivity has not been established. We conducted household transmission stud…
View article: Comparative Analysis of SARS-CoV-2 Antibody Responses across Global and Lesser-Studied Vaccines
Comparative Analysis of SARS-CoV-2 Antibody Responses across Global and Lesser-Studied Vaccines Open
Few data are available on antibody response for some SARS-CoV-2 vaccines, and there is a lack of ability to compare vaccine responses in the same population. This cross-sectional study conducted in Nicaragua examines the SARS-CoV-2 antibod…
View article: Reduction in Long COVID Symptoms and Symptom Severity in Vaccinated Compared to Unvaccinated Adults
Reduction in Long COVID Symptoms and Symptom Severity in Vaccinated Compared to Unvaccinated Adults Open
Background The impact of vaccination prior to infection on postacute sequelae of coronavirus disease 2019 (COVID-19, PASC), also known as long COVID, remains unclear. Here we assess the protective effect of vaccination on long COVID in a c…
View article: Increased influenza severity in children in the wake of SARS‐CoV‐2
Increased influenza severity in children in the wake of SARS‐CoV‐2 Open
The SARS‐CoV‐2 pandemic and subsequent interruption of influenza circulation has lowered population immunity to influenza, especially among children with few prepandemic exposures. Using data from a prospective pediatric cohort study based…
View article: Increased Influenza Severity in Children in the Wake of SARS-CoV-2
Increased Influenza Severity in Children in the Wake of SARS-CoV-2 Open
The SARS-CoV-2 pandemic and subsequent interruption of influenza circulation has lowered population immunity to influenza, especially among children with few pre-pandemic exposures. We compared the incidence and severity of influenza A/H3N…
View article: SARS‐CoV‐2 infection‐induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study
SARS‐CoV‐2 infection‐induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study Open
Background Much of the world's population has been infected with SARS‐CoV‐2. Thus, immunity from prior infection will play a critical role in future SARS‐CoV‐2 transmission. We investigated the impact of infection‐induced immunity on viral…
View article: The Spectrum of Influenza in Children
The Spectrum of Influenza in Children Open
Background Children constitute an important component of the influenza burden and community transmission, but the frequency of asymptomatic infection and post-influenza sequelae at the community level is poorly understood. Methods Two comm…
View article: Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua
Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua Open
Background Human metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in ch…
View article: Protection Associated with Previous SARS-CoV-2 Infection in Nicaragua
Protection Associated with Previous SARS-CoV-2 Infection in Nicaragua Open
View article: Association of SARS-CoV-2 Seropositivity and Symptomatic Reinfection in Children in Nicaragua
Association of SARS-CoV-2 Seropositivity and Symptomatic Reinfection in Children in Nicaragua Open
In this prospective, community-based pediatric cohort study, rates of symptomatic and severe COVID-19 were highest among the youngest participants, with rates stabilizing at approximately 5 years of age. In addition, symptomatic reinfectio…
View article: SARS-CoV-2 infection-induced immunity and the duration of viral shedding: results from a Nicaraguan household cohort study
SARS-CoV-2 infection-induced immunity and the duration of viral shedding: results from a Nicaraguan household cohort study Open
Background Much of the world’s population has been infected with SARS-CoV-2. Thus, infection-induced immunity will play a critical role in future SARS-CoV-2 transmission. We investigated the impact of immunity from prior infection on viral…
View article: Pediatric burden and seasonality of Human Metapneumovirus over five years in Managua, Nicaragua.
Pediatric burden and seasonality of Human Metapneumovirus over five years in Managua, Nicaragua. Open
Background Human Metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in ch…
View article: The Nicaraguan Pediatric Influenza Cohort Study, 2011–2019: Influenza Incidence, Seasonality, and Transmission
The Nicaraguan Pediatric Influenza Cohort Study, 2011–2019: Influenza Incidence, Seasonality, and Transmission Open
Background Children account for a large portion of global influenza burden and transmission, and a better understanding of influenza in children is needed to improve prevention and control strategies. Methods To examine the incidence and t…
View article: The Nicaraguan Pediatric Influenza Cohort Study, 2011-2019: influenza incidence, seasonality, and transmission
The Nicaraguan Pediatric Influenza Cohort Study, 2011-2019: influenza incidence, seasonality, and transmission Open
Background Children account for a large portion of global influenza burden and transmission, and a better understanding of influenza in children is needed to improve prevention and control strategies. Methods To examine the incidence and t…
View article: Burden of SARS-CoV-2 and protection from symptomatic second infection in children
Burden of SARS-CoV-2 and protection from symptomatic second infection in children Open
Importance The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their protection against re-infection is crucial as they will be among the last groups vaccinat…
View article: An immune correlate of SARS-CoV-2 infection and severity of reinfections
An immune correlate of SARS-CoV-2 infection and severity of reinfections Open
Background An immune correlate of protection from SARS-CoV-2 infection is urgently needed. Methods We used an ongoing household cohort with an embedded transmission study that closely monitors participants regardless of symptom status. Rea…
View article: Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection
Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection Open
Background There are few data on the full spectrum of disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across the lifespan from community-based or nonclinical settings. Methods We followed 2338 peopl…
View article: Epidemics of chikungunya, Zika, and COVID-19 reveal bias in case-based mapping
Epidemics of chikungunya, Zika, and COVID-19 reveal bias in case-based mapping Open
Accurate tracing of epidemic spread over space enables effective control measures. We examined three metrics of infection and disease in a pediatric cohort (N ≈ 3,000) over two chikungunya and one Zika epidemic, and in a household cohort (…
View article: Epidemics of Chikungunya, Zika, and COVID-19 Reveal Bias in Case-Based Mapping
Epidemics of Chikungunya, Zika, and COVID-19 Reveal Bias in Case-Based Mapping Open
View article: Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection
Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection Open
Background Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we do not understand the influence of obesity on susceptibility to infection or on nonsevere influenza outcomes. M…
View article: Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults
Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults Open
It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 that the first infection(s) with influenza virus leaves a special immunological imprint which shapes immune responses to future infections wi…
View article: Pre-existing Antineuraminidase Antibodies Are Associated With Shortened Duration of Influenza A(H1N1)pdm Virus Shedding and Illness in Naturally Infected Adults
Pre-existing Antineuraminidase Antibodies Are Associated With Shortened Duration of Influenza A(H1N1)pdm Virus Shedding and Illness in Naturally Infected Adults Open
Background Influenza causes a substantial burden worldwide, and current seasonal influenza vaccine has suboptimal effectiveness. To develop better, more broadly protective vaccines, a more thorough understanding is needed of how antibodies…
View article: Obesity Increases the Duration of Influenza A Virus Shedding in Adults
Obesity Increases the Duration of Influenza A Virus Shedding in Adults Open
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shed…