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View article: Preventing gambling‐related harm in adolescents (PRoGRAM‐A), a secondary school‐based social network intervention: Results from a pilot cluster randomised controlled trial
Preventing gambling‐related harm in adolescents (PRoGRAM‐A), a secondary school‐based social network intervention: Results from a pilot cluster randomised controlled trial Open
Aim To conduct a pilot cluster randomised controlled trial (cRCT) of a gambling prevention intervention (PRoGRAM‐A) among young people aged 13–15 to determine the utility of conducting a Phase III RCT assessing effectiveness and cost‐effec…
View article: Preventing gambling‑related harm in adolescents: a pilot cluster randomized controlled trial
Preventing gambling‑related harm in adolescents: a pilot cluster randomized controlled trial Open
Introduction PRoGRAM-A (Preventing Gambling Related Harm in Adolescents) is a peer-led, social network intervention to protect young people, their friends and family members from gambling related harm (GRH), through student led message dif…
View article: Safety, feasibility and efficacy of exercise as an airway clearance technique in cystic fibrosis: a randomised pilot feasibility trial
Safety, feasibility and efficacy of exercise as an airway clearance technique in cystic fibrosis: a randomised pilot feasibility trial Open
Objectives To test the feasibility and safety of exercise as an airway clearance technique (ExACT) for people with cystic fibrosis (pwCF) versus usual care (UC). Methods Dual-site, two-arm randomised pilot trial. Fifty pwCF (≥10 years, for…
View article: Post stroke intervention trial in fatigue (POSITIF): Randomised multicentre feasibility trial
Post stroke intervention trial in fatigue (POSITIF): Randomised multicentre feasibility trial Open
Objective To test the feasibility of a telephone delivered intervention, informed by cognitive behavioural principles, for post-stroke fatigue, and estimated its effect on fatigue and other outcomes. Design Randomised controlled parallel g…
View article: Physiological deterioration in the Emergency Department: The SNAP40-ED study
Physiological deterioration in the Emergency Department: The SNAP40-ED study Open
Continuous novel ambulatory monitoring may detect deterioration in Emergency Department (ED) patients more rapidly, prompting treatment and preventing adverse events. Single-centre, open-label, prospective, observational cohort study recru…
View article: Separation and the information theory surrogate evaluation approach: A penalised likelihood solution
Separation and the information theory surrogate evaluation approach: A penalised likelihood solution Open
Surrogate evaluation is an important topic in clinical trials research, the use of a surrogate in place of a primary endpoint of interest is a common occurrence but also a contentious issue that is much debated. Statistical techniques to a…
View article: A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients Open
Background: Delirium is a common and serious acute neuropsychiatric syndrome which is often missed in routine clinical care. Inattention is the core cognitive feature. Diagnostic test accuracy (including cut-points) of a smartphone Deliriu…
View article: Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes
Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes Open
In clinical trials, surrogate outcomes are early measures of treatment effect that are used to predict treatment effect on a later primary outcome of interest: the primary outcome therefore does not need to be observed and trials can be sh…
View article: Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS Open
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be responsible for late term abortion in small ruminants. Challenge w…
View article: Statistical evaluation of surrogate outcomes : methodological extensions to ordinal outcomes with applications in acute stroke
Statistical evaluation of surrogate outcomes : methodological extensions to ordinal outcomes with applications in acute stroke Open
Background
\nSurrogate outcomes are measures of treatment effect that can be used to predict treatment effect
\non the true outcome of interest. Surrogates are valued as they can be used in place of true
\noutcomes to reduce the length, si…
View article: Development of a sensitive method to extract and detect low numbers of Cryptosporidium oocysts from adult cattle faecal samples
Development of a sensitive method to extract and detect low numbers of Cryptosporidium oocysts from adult cattle faecal samples Open
Cryptosporidium transmission studies to date have concluded that adult cattle are not a significant source of oocysts contributing to clinical cryptosporidiosis in calves on farm. However current methods of sample processing have been opti…