Hannah J. Lomax-Browne
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View article: The genetics and epidemiology of<i>N-</i>and<i>O-</i>IgA glycomics
The genetics and epidemiology of<i>N-</i>and<i>O-</i>IgA glycomics Open
Immunoglobulin (Ig) glycosylation modulates the immune response, and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylati…
View article: Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis Open
Background and objectives C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approxi…
View article: O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function
O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function Open
Significance Statement IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide, with galactose-deficient IgA (gd-IgA) considered to play a key role in its pathogenesis. Although this association is widely reported, i…
View article: Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice
Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice Open
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful…
View article: Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage
Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage Open
Significance The complement system is integral to innate immunity and host defense. However, inappropriate activation causes host tissue damage and disease. In health, this is prevented by a complex protein network that includes the factor…
View article: Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment
Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment Open
Glomerular FHR5 is highly prevalent in C3G, interacts with glomerular C3, and is associated with markers of disease severity. Glomerular FHR5 likely exacerbates complement-mediated glomerular damage in C3G and its interaction with glomerul…
View article: Supplementary material from "Serum IgA1 shows increased levels of <i>α</i>2,6 linked sialic acid in breast cancer"
Supplementary material from "Serum IgA1 shows increased levels of <i>α</i>2,6 linked sialic acid in breast cancer" Open
The lectin Helix pomatia agglutinin (HPA) recognizes altered glycosylation in solid cancers and the identification of HPA binding partners in tumour tissue and serum is an important aim. Among the many HPA binding proteins, IgA1 has…
View article: Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition
Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition Open
View article: Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy
Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy Open
IgA nephropathy (IgAN) is a common cause of chronic kidney disease and end-stage renal failure, especially in young people. Due to a wide range of clinical outcomes and difficulty in predicting response to immunosuppression, we need to und…
View article: Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors
Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors Open
Alterations in protein glycosylation are a key feature of oncogenesis and have been shown to affect cancer cell behaviour perturbing cell adhesion, favouring cell migration and metastasis. This study investigated the effect of N-linked gly…
View article: IgA1 Glycosylation Is Heritable in Healthy Twins
IgA1 Glycosylation Is Heritable in Healthy Twins Open
IgA nephropathy (IgAN) is the most common form of primary GN and an important cause of kidney failure. Characteristically, patients with IgAN have increased serum levels of undergalactosylated IgA1 (gd-IgA1). To assess the degree to which …
View article: FO039THE NATIONAL STUDY OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRTIS AND C3 GLOMERULOPATHY - CHARACTERISATION OF THE PAEDIATRIC COHORT
FO039THE NATIONAL STUDY OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRTIS AND C3 GLOMERULOPATHY - CHARACTERISATION OF THE PAEDIATRIC COHORT Open