Hannah K. Dorando
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View article: Targeting LAIR1-mediated immunosuppression adds a new weapon to our immunotherapy arsenal
Targeting LAIR1-mediated immunosuppression adds a new weapon to our immunotherapy arsenal Open
Leukocyte-associated Ig-like receptor 1 (LAIR1) is a collagen-binding inhibitory immune receptor that negatively regulates cellular activation. In this issue of the JCI, Tao et al. show that LAIR1-inhibitory signaling plays an important ro…
View article: Single Cell Resolution Tracking of Cutaneous T-Cell Lymphoma Reveals Clonal Evolution in Disease Progression
Single Cell Resolution Tracking of Cutaneous T-Cell Lymphoma Reveals Clonal Evolution in Disease Progression Open
Cutaneous T-cell lymphoma (CTCL) remains a challenging disease due to its significant heterogeneity, therapy resistance, and relentless progression. Multi-omics technologies offer the potential to provide uniquely precise views of disease …
View article: LAIR1 prevents excess inflammatory tissue damage in<i>S. aureus</i>skin infection and Cutaneous T-cell Lymphoma
LAIR1 prevents excess inflammatory tissue damage in<i>S. aureus</i>skin infection and Cutaneous T-cell Lymphoma Open
Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the causative immune defect is unclear. We previously identified high levels of LAIR2, a decoy protein …
View article: Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation
Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation Open
The surface receptor CD8α is present on 20%-80% of human (but not mouse) NK cells, yet its function on NK cells remains poorly understood. CD8α expression on donor NK cells was associated with a lack of therapeutic responses in patients wi…
View article: Epigenetic regulation of Leukocyte associated immunoglobulin-like receptors 1 and 2 by interferon signaling in macrophages and T cells
Epigenetic regulation of Leukocyte associated immunoglobulin-like receptors 1 and 2 by interferon signaling in macrophages and T cells Open
Background Inhibitory immune receptors are important for maintaining immune homeostasis. We recently identified epigenetic alterations in two members of this group, LAIR1 and LAIR2, in patients with inflammatory tissue damage and recurrent…
View article: Leukocyte associated immunoglobulin-like receptor 1 modulates immune response to <i>Staphylococcus aureus</i> infection
Leukocyte associated immunoglobulin-like receptor 1 modulates immune response to <i>Staphylococcus aureus</i> infection Open
Immunity is a balance of maximal pathogen defense with minimal host damage. Inhibitory immune receptors are important for maintaining this balance. We recently identified elevated levels of leukocyte-associated immunoglobulin (Ig)-like rec…
View article: Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription
Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription Open
Human respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in the pediatric, elderly, and immunocompromised individuals. RSV non-structural protein NS1 is a known cytosolic immune antagonist, but how NS…
View article: BCALM (AC099524.1) Is a Human B Lymphocyte–Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling
BCALM (AC099524.1) Is a Human B Lymphocyte–Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling Open
Of the thousands of long noncoding RNAs (lncRNA) identified in lymphocytes, very few have defined functions. In this study, we report the discovery and functional elucidation of a human B cell–specific lncRNA with high levels of expression…