Hannah K. Giannini
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View article: Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease
Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) increases risk of cardiovascular disease yet the molecular mechanisms driving this association remain incompletely understood. We hypothesized that aberrant monocyte-endothe…
View article: Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells
Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells Open
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA overexpressed in various cancers that promotes cell growth and metastasis. Although hypoxia has been shown to up-regulate MALAT1, only hypoxia-inducibl…