Explanipedia

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1 Open

Hannah L. Itell, Jamie Guenthoer, Daryl Humes, Nell E. Baumgarten, Julie Overbaugh · 2024

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1 Open

Hannah L. Itell, Daryl Humes, Nell E. Baumgarten, Julie Overbaugh · 2023

HIV-1 infection involves a selection bottleneck that leads to transmission of one or a few HIV variants, which nearly always use CCR5 as the coreceptor (R5 viruses) for viral entry as opposed to CXCR4 (X4 viruses). The host properties that…

Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4+ T cells Open

Hannah L. Itell, Daryl Humes, Julie Overbaugh · 2023

Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4<sup>+</sup>T cells Open

Hannah L. Itell, Daryl Humes, Julie Overbaugh · 2023

SUMMARY Type I interferon (IFN) upregulates proteins that inhibit HIV within infected cells. Prior studies have identified IFN-stimulated genes (ISGs) that impede lab-adapted HIV in cell lines, yet the ISG(s) that mediate IFN restriction i…

Comparison of nucleocapsid and spike antibody ELISAs for determining SARS‐CoV‐2 seropositivity in Kenyan women and infants Open

Carolyn S. Fish, Prestone Owiti, Emily R. Begnel, Hannah L. Itell, Ednah Ojee , et al. · 2022

A multitude of enzyme‐linked immunosorbent assays (ELISAs) has been developed to detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibodies since the coronavirus disease 2019 pandemic started in late 2019. Assessing the…

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques Open

Stella J. Berendam, Papa K. Morgan-Asiedu, Riley J. Mangan, Shuk Hang Li, Holly Heimsath , et al. · 2021

Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody res…

SARS-CoV-2 Antibody Binding and Neutralization in Dried Blood Spot Eluates and Paired Plasma Open

Hannah L. Itell, Haidyn Weight, Carolyn S. Fish, Jennifer K. Logue, Nicholas Franko , et al. · 2021

Plasma and sera isolated from venous blood represent conventional sample types used for the evaluation of SARS-CoV-2 antibody responses after infection or vaccination. However, collection of these samples is invasive and requires trained p…

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques Open

Stella J. Berendam, Papa K. Morgan-Asiedu, Riley J. Mangan, S L Li, Holly Heimsath , et al. · 2021

Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody res…

SARS-CoV-2 antibody binding and neutralization in dried blood spot eluates and paired plasma Open

Hannah L. Itell, Haidyn Weight, Carolyn S. Fish, Jennifer K. Logue, Nicholas Franko , et al. · 2021

Widescale assessment of SARS-CoV-2-specific antibodies is critical to understanding population seroprevalence, correlates of protection, and the longevity of vaccine-elicited responses. Most SARS-CoV-2 studies characterize antibody respons…

A diverse collection of B cells responded to HIV infection in infant BG505 Open

Cassandra A. Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore A. Gobillot, Meghan Garrett , et al. · 2021

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response in natural infection and cross-reactivity with endemic human CoVs Open

Caitlin I. Stoddard, Jared Galloway, Helen Y. Chu, Mackenzie M. Shipley, Kevin Sung , et al. · 2021

A major goal of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efforts is to elicit antibody responses that confer protection. Mapping the epitope targets of the SARS-CoV-2 antibody response is critical for va…

High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies Open

Meghan Garrett, Jared Galloway, Helen Y. Chu, Hannah L. Itell, Caitlin I. Stoddard , et al. · 2021

High resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies Open

Meghan Garrett, Jared Galloway, Helen Y. Chu, Hannah L. Itell, Caitlin I. Stoddard , et al. · 2020

SUMMARY Defining long-term protective immunity to SARS-CoV-2 is one of the most pressing questions of our time and will require a detailed understanding of potential ways this virus can evolve to escape immune protection. Immune protection…

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response and cross-reactivity with endemic HCoVs Open

Caitlin I. Stoddard, Jared Galloway, Helen Y. Chu, Mackenzie M. Shipley, Hannah L. Itell , et al. · 2020

A major goal of current SARS-CoV-2 vaccine efforts is to elicit antibody responses that confer protection. Mapping the epitope targets of the SARS-CoV-2 antibody response is critical for innovative vaccine design, diagnostics, and developm…

Phage-DMS: A Comprehensive Method for Fine Mapping of Antibody Epitopes Open

Meghan Garrett, Hannah L. Itell, Katharine H. D. Crawford, Ryan Basom, Jesse D. Bloom , et al. · 2020

Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status Open

Annalisa Post, Shuk Hang Li, Madison Berry, Hannah L. Itell, David R. Martinez , et al. · 2020

Phage-DMS: a comprehensive method for fine mapping of antibody epitopes Open

Meghan Garrett, Hannah L. Itell, Katharine H. D. Crawford, Ryan Basom, Jesse D. Bloom , et al. · 2020

Understanding the antibody response is critical to developing vaccine and antibody-based therapies and has inspired the recent development of new methods to isolate antibodies. However, methods to define the antibody-antigen interactions t…

Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy Open

Tulika Singh, Cesar A. Lopez, Camila Giuberti, Maria Dennis, Hannah L. Itell , et al. · 2019

Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have n…

Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition Open

Frances M. Saccoccio, Jennifer A. Jenks, Hannah L. Itell, Shuk Hang Li, Madison Berry , et al. · 2019

Background Development of a cytomegalovirus (CMV) vaccine is a high priority. However, the ability of antibodies to protect against CMV infection is not well characterized. Studies of maternal antibodies in infants offer the potential to i…

Determinants of Tenascin-C and HIV-1 envelope binding and neutralization Open

Riley J. Mangan, Lisa Stamper, Tomoo Ohashi, Joshua Eudailey, Eden P. Go , et al. · 2019

Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon Open

Lauren H. Wyatt, Sallie R. Permar, Ernesto Ortiz, Axel Berky, Christopher W. Woods , et al. · 2019

Background: Poor nutritional status combined with mercury exposure can generate adverse child health outcomes. Diet is a mediator of mercury exposure and evidence suggests that nutritional status modifies aspects of mercury toxicity. Howev…

CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques Open

Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah L. Itell , et al. · 2018

Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling cha…

116. Role of Maternal Antibodies in Protection Against Postnatal Cytomegalovirus Acquisition Open

Frances M. Saccoccio, Hannah L. Itell, Skukhang Li, Jennifer A. Jenks, Guan Xie , et al. · 2018

Background Congenital cytomegalovirus (CMV) is the leading infectious cause of birth defects in the United States. Development of an effective CMV vaccine is a public health priority. However, CMV vaccine development is limited by a poor u…

Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys Open

Amitinder Kaur, Hannah L. Itell, Elizabeth P. Ehlinger, Valerie Varner, Soren Gantt , et al. · 2018

Despite exposure to RhCMV shedding in breast milk and other maternal fluids, postnatal mother-to-child RhCMV transmission appears to be less efficient than that of HCMV. A greater understanding of the determinants of RhCMV transmission and…

Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines Open

Hannah L. Itell, Erin McGuire, Petronella Muresan, Coleen K. Cunningham, Elizabeth J. McFarland , et al. · 2018

Because vaccine co-administration can affect elicited immune responses, it is important to evaluate new vaccines in the context of pre-existing vaccination schedules. This is particularly necessary for new pediatric vaccines, as the World …

Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques Open

Daniel R. Ram, Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar , et al. · 2018

Natural killer (NK) cells classically typify the nonspecific effector arm of the innate immune system, but have recently been shown to possess memory-like properties against multiple viral infections, most notably CMV. Expression of the ac…

HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine Open

Erin McGuire, Youyi Fong, Christopher Toote, Coleen K. Cunningham, Elizabeth J. McFarland , et al. · 2017

In the RV144 vaccine trial, IgG responses against the HIV envelope variable loops 1 and 2 (V1V2) were associated with decreased HIV acquisition risk. We previously reported that infants immunized with an MF59-adjuvanted rgp120 vaccine deve…

Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections Open

Hannah L. Itell, Amitinder Kaur, Jesse D. Deere, Peter A. Barry, Sallie R. Permar · 2017

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys Open

Cody S. Nelson, Diana Vera Cruz, Dollnovan Tran, Kristy M. Bialas, Lisa Stamper , et al. · 2017

Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of …

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys Open

Cody S. Nelson, Diana Vera Cruz, Dollnovan Tran, Kristy M. Bialas, Lisa Stamper , et al. · 2017

Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of …

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