Hannah L. Nathan
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View article: Developing a Risk Stratification Tool to Predict Patients with Gestational Diabetes Mellitus at Risk of Insulin Treatment: A Cohort Study
Developing a Risk Stratification Tool to Predict Patients with Gestational Diabetes Mellitus at Risk of Insulin Treatment: A Cohort Study Open
Objectives: We aimed to develop and validate a simple, easy-to-use risk stratification tool to use in the diagnosis of gestational diabetes mellitus (GDM) to triage those more likely to require insulin treatment. Methods: Using an audit of…
View article: Eclampsia among adolescent mothers in low- and middle-Income countries
Eclampsia among adolescent mothers in low- and middle-Income countries Open
Everyday, approximately 800 pregnant women die from preventable causes, with 95% of these deaths occurring in low- and middle-income countries. Adolescent mothers are disproportionally affected. Hypertensive disorders, including eclampsia,…
View article: Oral/Free Communication Session Abstracts
Oral/Free Communication Session Abstracts Open
Objectives: This study aimed to establish a correlation and strengthen the utilization of inflammatory and hematologic ratios in predicting GDM during the first trimester among Filipinos. Methods:A prospective cohort approach with 300 pati…
View article: Blood pressure thresholds in pregnancy for identifying maternal and infant risk: a secondary analysis of Community-Level Interventions for Pre-eclampsia (CLIP) trial data
Blood pressure thresholds in pregnancy for identifying maternal and infant risk: a secondary analysis of Community-Level Interventions for Pre-eclampsia (CLIP) trial data Open
View article: The ability and safety of community-based health workers to safely initiate lifesaving therapies for pre-eclampsia in Ogun State, Nigeria: An analysis of 260 community treatments with MgSO4 and/or methyldopa
The ability and safety of community-based health workers to safely initiate lifesaving therapies for pre-eclampsia in Ogun State, Nigeria: An analysis of 260 community treatments with MgSO4 and/or methyldopa Open
These findings demonstrate the ability of community-based health workers to safely administer methyldopa and intramuscular magnesium sulphate. The use of task-sharing, therefore, could drastically reduce the three delays (triage, transport…
View article: Effect of the CRADLE vital signs alert device intervention on referrals for obstetric haemorrhage in low-middle income countries: a secondary analysis of a stepped- wedge cluster-randomised control trial
Effect of the CRADLE vital signs alert device intervention on referrals for obstetric haemorrhage in low-middle income countries: a secondary analysis of a stepped- wedge cluster-randomised control trial Open
View article: Pregnancy Outcomes and Blood Pressure Visit-to-Visit Variability and Level in Three Less-Developed Countries
Pregnancy Outcomes and Blood Pressure Visit-to-Visit Variability and Level in Three Less-Developed Countries Open
In pregnancy in well-resourced settings, limited data suggest that higher blood pressure (BP) visit-to-visit variability may be associated with adverse pregnancy outcomes. Included were pregnant women in 22 intervention clusters of the CLI…
View article: Effect of The CRADLE Vital Signs Alert Device Intervention on Referrals for Obstetric Haemorrhage in Low-Middle Income Countries: A Secondary Analysis of A Stepped-Wedge Cluster-Randomised Control Trial
Effect of The CRADLE Vital Signs Alert Device Intervention on Referrals for Obstetric Haemorrhage in Low-Middle Income Countries: A Secondary Analysis of A Stepped-Wedge Cluster-Randomised Control Trial Open
Background Obstetric haemorrhage is the leading cause of maternal death worldwide, 99% of which occur in low and middle income countries. The majority of deaths and adverse events are associated with delays in identifying compromise and es…
View article: Community-level interventions for pre-eclampsia (CLIP) in Pakistan: A cluster randomised controlled trial
Community-level interventions for pre-eclampsia (CLIP) in Pakistan: A cluster randomised controlled trial Open
Objectives: To reduce all-cause maternal and perinatal mortality and major morbidity through Lady Health Worker (LHW)-facilitated community engagement and early diagnosis, stabilization and referral of women with preeclampsia, an important…
View article: Setting and techniques for monitoring blood pressure during pregnancy
Setting and techniques for monitoring blood pressure during pregnancy Open
The benefit, if any, of self-monitoring BP in hypertensive pregnancies remains uncertain, as the evidence is limited to one feasibility study. Current practice of using K5 to measure diastolic BP is supported for women with pregnancy hyper…
View article: Community level interventions for pre-eclampsia (CLIP) in India: A cluster randomised controlled trial
Community level interventions for pre-eclampsia (CLIP) in India: A cluster randomised controlled trial Open
View article: Community-level interventions for pre-eclampsia (CLIP) in Mozambique: A cluster randomised controlled trial
Community-level interventions for pre-eclampsia (CLIP) in Mozambique: A cluster randomised controlled trial Open
OBJECTIVES: Pregnancy hypertension is the third leading cause of maternal mortality in Mozambique and contributes significantly to fetal and neonatal mortality. The objective of this trial was to assess whether task-sharing care might redu…
View article: Pregnancy-Related Acute Kidney Injury in Preeclampsia
Pregnancy-Related Acute Kidney Injury in Preeclampsia Open
Preeclampsia is a common cause of acute kidney injury (AKI) in low- and middle-income countries, but AKI incidence in preeclampsia, its risk factors, and renal outcomes are unknown. A prospective observational multicenter study of women ad…
View article: Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: A prospective cohort study
Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: A prospective cohort study Open
Introduction Shock index ( SI ) is a predictor of hemodynamic compromise in obstetric patients. The SI threshold for action is not well understood. We aimed to evaluate SI thresholds as predictors of outcomes in obstetric patients. Materia…
View article: The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis
The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis Open
BackgroundMost pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters…
View article: Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial
Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial Open
View article: Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study.
Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study. Open
The incidence of pre-eclampsia complications, perinatal death and preterm delivery in women referred to tertiary care in South Africa was much higher than reported in other low- and middle-income studies and despite access to tertiary care…
View article: Development and evaluation of a novel Vital Signs Alert device for use in pregnancy in low-resource settings
Development and evaluation of a novel Vital Signs Alert device for use in pregnancy in low-resource settings Open
Objectives Haemorrhage, hypertension, sepsis and abortion complications (often from haemorrhage or sepsis) contribute to 60% of all maternal deaths. Each is associated with vital signs (blood pressure (BP) and pulse) abnormalities, and the…
View article: Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study
Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study Open
CITATION: Nathan, H. L., et al. 2018. Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa : a prospective cohort study. Journal of Global Health, 8(2):020401, doi:10.7189/jogh.08.…
View article: Innovations in vital signs measurement for the detection of hypertension and shock in pregnancy
Innovations in vital signs measurement for the detection of hypertension and shock in pregnancy Open
View article: Evaluation of a novel vital sign device to reduce maternal mortality and morbidity in low-resource settings: a mixed method feasibility study for the CRADLE-3 trial
Evaluation of a novel vital sign device to reduce maternal mortality and morbidity in low-resource settings: a mixed method feasibility study for the CRADLE-3 trial Open
View article: Evaluation of a novel device for the management of high blood pressure and shock in pregnancy in low-resource settings: study protocol for a stepped-wedge cluster-randomised controlled trial (CRADLE-3 trial)
Evaluation of a novel device for the management of high blood pressure and shock in pregnancy in low-resource settings: study protocol for a stepped-wedge cluster-randomised controlled trial (CRADLE-3 trial) Open
View article: The CRADLE vital signs alert: qualitative evaluation of a novel device designed for use in pregnancy by healthcare workers in low-resource settings
The CRADLE vital signs alert: qualitative evaluation of a novel device designed for use in pregnancy by healthcare workers in low-resource settings Open
View article: The Incidence of Pregnancy Hypertension in the Community Level Interventions for Pre-Eclampsia (CLIP) Trials - Population-Level Data from India, Pakistan, Mozambique, and Nigeria
The Incidence of Pregnancy Hypertension in the Community Level Interventions for Pre-Eclampsia (CLIP) Trials - Population-Level Data from India, Pakistan, Mozambique, and Nigeria Open
View article: Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study
Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study Open
The CRADLE VSA, with integrated traffic light early warning system, can identify women who are hypertensive, at increased risk of severe pre-eclampsia complications and in need of escalation of care. Women who triggered a red light were at…
View article: The Effect of Intensive Care Unit Admission on Smokers’ Attitudes and Their Likelihood of Quitting Smoking
The Effect of Intensive Care Unit Admission on Smokers’ Attitudes and Their Likelihood of Quitting Smoking Open
We sought to estimate the proportion of patients admitted to a metropolitan intensive care unit (ICU) who were current smokers, and the relationships between ICU survivors who smoked and smoking cessation and/or reduction six months post–I…
View article: Setting and techniques for monitoring blood pressure during pregnancy
Setting and techniques for monitoring blood pressure during pregnancy Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of setting and technique of BP measurement for diagnosing hypertensive disorders in pregnancy on subsequent maternal and perinata…
View article: Reverse innovation in maternal health
Reverse innovation in maternal health Open
Reverse innovation, defined as the flow of ideas from low- to high-income settings, is gaining traction in healthcare. With an increasing focus on value, investing in low-cost but effective and innovative solutions can be of mutual benefit…
View article: Determination of Normal Ranges of Shock Index and Other Haemodynamic Variables in the Immediate Postpartum Period: A Cohort Study
Determination of Normal Ranges of Shock Index and Other Haemodynamic Variables in the Immediate Postpartum Period: A Cohort Study Open
This is the first study to determine normal ranges of maternal BP, MAP, HR and SI within one hour of birth, a time of considerable haemodynamic adjustment, with minimal effect of demographic and obstetric factors demonstrated. The lower 90…
View article: Vital Sign Prediction of Adverse Maternal Outcomes in Women with Hypovolemic Shock: The Role of Shock Index
Vital Sign Prediction of Adverse Maternal Outcomes in Women with Hypovolemic Shock: The Role of Shock Index Open
For women with hypovolemic shock from obstetric hemorrhage, shock index was consistently a strong predictor of all adverse outcomes. In lower-level facilities in low resource settings, we recommend a shock index threshold of ≥ 0.9 indicati…