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View article: Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency (SCID): A PIDTC study
Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency (SCID): A PIDTC study Open
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for severe combined immunodeficiency (SCID). Since the initiation of newborn screening (NBS), survival rates have improved significantly, but the impact of HCT up…
View article: Real-world outcomes for young adult patients receiving CD19 CAR T-cell therapy
Real-world outcomes for young adult patients receiving CD19 CAR T-cell therapy Open
Tisagenlecleucel (tisa-cel) and brexucabtagene autoleucel (brexu-cel) are approved CD19 chimeric antigen receptor T-cell therapy (CAR T) products for young adults (YA) with relapsed/refractory B-cell acute lymphoblastic leukemia. A distinc…
View article: Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity
Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity Open
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment strategy for patients with inborn errors of immunities (IEIs). The objective of this study was to assess the optimal busulfan exposure before allogenei…
View article: Immune-Modifying Microparticles for Treatment of Acute Graft-Versus-Host-Disease
Immune-Modifying Microparticles for Treatment of Acute Graft-Versus-Host-Disease Open
Background Acute Graft versus host disease (aGVHD) is one of the most common complication of allogeneic hematopoietic stem cell transplant. We have previously shown that infused immune-modifying particles (IMPs) can reduce clinical symptom…
View article: 1771. End-of-Life Use of Antibiotics in Pediatric Patients
1771. End-of-Life Use of Antibiotics in Pediatric Patients Open
Background Antibiotic use at the end of life is common in adult patients but little is known about children. While important to treat and prevent infection in these vulnerable populations, unnecessary antibiotic exposure may result in adve…