Hannah M. Nelson
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View article: 5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles
5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles Open
5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair. H…
View article: Transfer of <i>miR-100</i> and <i>miR-125b</i> increases 3D growth and invasiveness in recipient cancer cells
Transfer of <i>miR-100</i> and <i>miR-125b</i> increases 3D growth and invasiveness in recipient cancer cells Open
Aim: Extracellular communication via the transfer of vesicles and nanoparticles is now recognized to play an important role in tumor microenvironment interactions. Cancer cells upregulate and secrete abundant levels of miR-100 and miR-125b…
View article: <i>miR-100</i>and<i>miR-125b</i>Contribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells
<i>miR-100</i>and<i>miR-125b</i>Contribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells Open
Extracellular communication via the transfer of vesicles and nanoparticles is now recognized to play an important role in tumor microenvironment interactions. Cancer cells upregulate and secrete abundant levels of miR-100 and miR-125b that…
View article: Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Devario malabaricus)
Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Devario malabaricus) Open
Giant danios (genus Devario), like zebrafish, are teleosts belonging to the danioninae subfamily of cyprinids. Adult giant danios are used in a variety of investigations aimed at understanding cellular and physiological processes, includin…