Hannah Maynard
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Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction Open
Despite robust ketosis, shifting substrate use away from carbohydrates, and decreasing estimated left ventricular filling pressures, acute KE supplementation did not improve peak VO2 or constant-intensity exercise in HFpEF. (Ketogenic Exog…
The role of suicidal mental imagery and experiential avoidance in suicidality: an exploratory study Open
Background: Although research has highlighted that suicidal imagery (SuiMI) and experiential avoidance (EA) are important in understanding suicidality, there is a need to understand how they potentially interact. Previous research has high…
View article: Determinants of Cardio-Ankle Vascular Index and Heart-Thigh β Index in the MESA
Determinants of Cardio-Ankle Vascular Index and Heart-Thigh β Index in the MESA Open
BACKGROUND: The cardio-ankle vascular index (CAVI) and heart-thigh β index (htβ) assess arterial stiffness by correcting pulse wave velocity for blood pressure to achieve less dependency on blood pressure variations. Normative data for the…
View article: Thoracic Aortic Three-Dimensional Geometry
Thoracic Aortic Three-Dimensional Geometry Open
Background: Aortic structure impacts cardiovascular health through multiple mechanisms. Aortic structural degeneration occurs with aging, increasing left ventricular afterload and promoting increased arterial pulsatility and target organ d…
Potassium Nitrate in Heart Failure With Preserved Ejection Fraction Open
Importance Nitric oxide deficiency may contribute to exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). Prior pilot studies have shown improvements in exercise tolerance with single-dose and short…
Psychological Factors Protecting Against Suicidality in Older Adults: A Systematic Review Open
Objective Suicide rates in older adults are often the highest of any age group, particularly among high income countries. However, there is a limited understanding of the factors that could protect against suicidality in older age. This sy…
View article: Thoracic Aortic Three-Dimensional Geometry
Thoracic Aortic Three-Dimensional Geometry Open
Background Aortic structure impacts cardiovascular health through multiple mechanisms. Aortic structural degeneration occurs with aging, increasing left ventricular afterload and promoting increased arterial pulsatility and target organ da…
The role of suicidal mental imagery and experiential avoidance in suicidality: An exploratory study Open
Objective: The purpose of this study was to explore the influence of suicide-related mental imagery (SuiMI) and experiential avoidance (EA) on suicidality. It was hypothesised that greater frequency of SuiMI would be associated with greate…
Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings Open
Background With limited information on germline mutations in biliary tract cancers, this study performed somatic and germline testing for patients at Memorial Sloan Kettering Cancer Center with known biliary tract carcinoma with the aim of…
Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms Open
PGAs frequently occur in pancreas exocrine neoplasms and involve multiple genes beyond those previously associated with hereditary pancreatic cancer. These PGAs are therapeutically actionable in about 5% to 10% of patients. These data supp…
Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline <i>BRCA</i> mutation carriers and wild‐type <i>BRCA</i> pancreatic ductal adenocarcinoma Open
BACKGROUND A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA 1/2‐mutate…
View article: Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer
Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer Open
In this retrospective analysis, the prognosis of surgically resectable BRCA-associated PDAC is no different than that of sporadic PDAC from the same institution. The role of platinum-based adjuvant therapy in this setting requires prospect…