Hannah Tabakh
YOU?
Author Swipe
View article: RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection
RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection Open
Transposon sequencing (Tn-seq) is a powerful genome-wide technique to assess bacterial fitness under varying growth conditions. However, screening via Tn-seq in vivo is challenging. Dose limitations and host restrictions create bottlenecks…
View article: Protocol for the transformation and engineering of edible algae Arthrospira platensis to generate heterologous protein-expressing strains
Protocol for the transformation and engineering of edible algae Arthrospira platensis to generate heterologous protein-expressing strains Open
Here, we present a protocol for harnessing the natural transformability of the edible algae Arthrospira platensis (common name: spirulina) to generate strains that express heterologous proteins. We describe the preparation of plasmids and …
View article: Using synthetic activity to design ultra-potent antibody cocktails
Using synthetic activity to design ultra-potent antibody cocktails Open
Drugs which independently inhibit a shared target or pathway can have synthetic activities that result in multiplicative instead of merely additive potencies. This characteristic of drug combinations can be quantified by expressing the pot…
View article: Author response: 4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen
Author response: 4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen Open
View article: 4-hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen
4-hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen Open
Pathogens encounter numerous antimicrobial responses, including the reactive oxygen species (ROS) burst. ROS-mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) generates the toxic alpha-beta carbonyl 4-hydroxy-2-nonen…
View article: Characterizing the mechanisms of resistance to the novel antimicrobial 4-hydroxy-2-nonenal by the model pathogen Listeria monocytogenes
Characterizing the mechanisms of resistance to the novel antimicrobial 4-hydroxy-2-nonenal by the model pathogen Listeria monocytogenes Open