Hannah Walgrave
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View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of Alzheimer’s Disease (AD) is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attent…
View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of AD is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attention also in AD researc…
View article: microRNA-132 regulates gene expression programs involved in microglial homeostasis
microRNA-132 regulates gene expression programs involved in microglial homeostasis Open
microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathologie…
View article: The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives Open
View article: Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease Open
View article: microRNA-132 regulates adult neural stem cells and their progeny to restore hippocampal neurogenesis and memory in Alzheimer’s disease
microRNA-132 regulates adult neural stem cells and their progeny to restore hippocampal neurogenesis and memory in Alzheimer’s disease Open
Neural stem cells residing in the hippocampal neurogenic niche sustain life-long neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally linked to mnemonic and cognitive plasticity in humans and rodents. In Al…
View article: Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement
Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement Open
Summary Adult hippocampal neurogenesis (AHN) plays a crucial role in memory processes and is impeded in the brains of Alzheimer’s disease (AD) patients. However, the molecular mechanisms impacting AHN in AD brain are unknown. Here we ident…
View article: Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases
Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases Open
View article: Increased gut permeability in cancer cachexia: mechanisms and clinical relevance
Increased gut permeability in cancer cachexia: mechanisms and clinical relevance Open
Intestinal disorders often occur in cancer patients, in association with body weight loss, and this alteration is commonly attributed to the chemotherapy. Here, using a mouse model of cancer cachexia induced by ectopic transplantation of C…
View article: Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?
Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota? Open
Aging predisposes to hepatic dysfunction and inflammation that can contribute to the development of non-alcoholic fatty liver disease. Spirulina, a cyanobacterium used as a food additive or food supplement, has been shown to impact immune …