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View article: Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding Open
Serotonin plays a prominent role in neurodevelopment, regulating processes from cell division to synaptic connectivity. Clinical studies suggest that alterations in serotonin signalling such as genetic polymorphisms or antidepressant expos…
View article: Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage
Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage Open
During subarachnoid haemorrhage, a blood clot forms in the subarachnoid space releasing extracellular haemoglobin (Hb), which causes oxidative damage and cell death in surrounding tissues. High rates of disability and cognitive decline in …
View article: A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau
A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau Open
In Alzheimer’s disease, tau pathology is thought to spread via a prion-like manner along connected neuronal networks. For this to occur, the usually cytosolic tau protein must be secreted via an unconventional mechanism prior to uptake int…
View article: Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation
Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation Open
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently affecting young to middle-aged adults, with an unmet need to improve outcome. This special report focusses on the development of intrathecal haptoglobin s…
View article: Functional effects of haemoglobin can be rescued by haptoglobin in an<i>in vitro</i>model of subarachnoid haemorrhage
Functional effects of haemoglobin can be rescued by haptoglobin in an<i>in vitro</i>model of subarachnoid haemorrhage Open
During subarachnoid haemorrhage, a blood clot forms in the subarachnoid space releasing extracellular haemoglobin (Hb), which causes oxidative damage and cell death in surrounding tissues. High rates of disability and cognitive decline in …
View article: Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer’s Disease: A Review
Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer’s Disease: A Review Open
Cognitive dysfunction in Alzheimer’s disease (AD) is caused by disturbances in neuronal circuits of the brain underpinned by synapse loss, neuronal dysfunction and neuronal death. Amyloid beta and tau protein cause these pathological chang…