Explanipedia

Distinct Morphological Types of Small Airway Obstructions in Smokers with Emphysema and End-Stage Chronic Obstructive Pulmonary Disease Open

Vincent Geudens, Charlotte De Fays, Lynn Willems, Astrid Vermaut, Gitte Aerts , et al. · 2025

Rationale: The precise nature of small airway obstructions in chronic obstructive pulmonary disease (COPD) remains poorly understood, especially at early disease stages. Objectives: This study aimed to characterize small airw…

Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease Open

Y. Khaled Mohamed Elm Mohamady, Vincent Geudens, Charlotte De Fays, Marta Zapata, Omar Hagrass , et al. · 2025

Supported by the KU Leuven (C16/19/005).

The Clinical Significance of HLA Compatibility Scores in Lung Transplantation Open

Liesbeth Daniëls, Hanne Beeckmans, Andrea Zajacová, Pieterjan Kerckhof, Saskia Bos , et al. · 2025

Lung transplantation is a life-saving therapeutic option for many chronic end-stage pulmonary diseases, but long-term survival may be limited by rejection of the transplanted organ. Since HLA disparity between donor and recipient plays a m…

Donor-derived cell-free DNA in chronic lung allograft dysfunction phenotypes: a pilot study Open

Hanne Beeckmans, Angelica Pagliazzi, Pieterjan Kerckhof, R. Hofkens, F. Debackere , et al. · 2024

Long-term survival after lung transplantation is limited due to chronic lung allograft dysfunction (CLAD), which encompasses two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Donor-deriv…

Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs Open

Seppe Cambier, Fabio Beretta, A. Nooyens, Mieke Metzemaekers, Noëmie Pörtner , et al. · 2024

Donor-Specific Blood Transfusion in Lung Transplantation Open

Xin Jin, Jacques Pirenne, Robin Vos, Charlotte Hooft, Janne Kaes , et al. · 2024

Lung transplantation is still hindered by a high rate of chronic rejection necessitating profound immunosuppression with its associated complications. Donor-specific blood transfusion is a pre-transplant strategy aimed at improving graft a…

The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study Open

Tobias Heigl, Janne Kaes, Céline Aelbrecht, Jef Serré, Yoshito Yamada , et al. · 2024

Introduction Chronic rejection is a major complication post-transplantation. Within lung transplantation, chronic rejection was considered as airway centred. Chronic Lung Allograft Dysfunction (CLAD), defined to cover all late chronic comp…

Ventilatory capacity in CLAD is driven by dysfunctional airway structure Open

Pieterjan Kerckhof, Gene Philip Louie Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens , et al. · 2024

The Immunopathology of Pulmonary Rejection after Murine Lung Transplantation Open

Janne Kaes, Emilie Pollenus, Charlotte Hooft, Hengshuo Liu, Céline Aelbrecht , et al. · 2024

To improve outcomes following lung transplantation, it is essential to understand the immunological mechanisms that result in chronic graft failure. The associated clinical syndrome is termed chronic lung allograft dysfunction (CLAD), whic…

COVID-19 Outcomes in Lung Transplant Recipients Following Pre-Exposure Prophylaxis With Tixagevimab-Cilgavimab During the Omicron BA.5 Surge: A Single Center Analysis Open

Saartje Demolder, Veronique Schaevers, Katrien Lagrou, Paul De Munter, Hanne Beeckmans , et al. · 2024

Lung transplant (LTx) recipients are at high risk for COVID-19 related morbidity and mortality. Data regarding pre-exposure prophylaxis (PrEP) with tixagevimab-cilgavimab in this population are scarce. We therefore evaluated COVID-19 break…

Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease Open

Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut , et al. · 2023

Rationale COPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered m…

COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT Open

Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos , et al. · 2023

COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.

Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction Open

Saskia Bos, Pauline Pradère, Hanne Beeckmans, Andrea Zajacová, Bart Vanaudenaerde , et al. · 2023

P188 Heterogeneity of large and small airway remodeling in human endstage explant cystic fibrosis lungs Open

Astrid Vermaut, Vincent Geudens, Lynn Willems, Janne Kaes, Hanne Beeckmans , et al. · 2023

Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation Open

Hanne Beeckmans, Elfri Van Roy, Janne Kaes, Annelore Sacreas, Vincent Geudens , et al. · 2023

Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of pr…

Allogeneic Hematopoietic Stem Cell Transplantation After Prior Lung Transplantation for Hereditary Pulmonary Alveolar Proteinosis: A Case Report Open

Hanne Beeckmans, Gene P. L. Ambrocio, Saskia Bos, Astrid Vermaut, Vincent Geudens , et al. · 2022

Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disorder characterized by surfactant accumulation in the small airways due to defective clearance by alveolar macrophages, resulting in impaired gas exchange. Whole lung lavage i…

Chronic Lung Allograft Dysfunction: More Than Meets the Eye? Open

Hanne Beeckmans, Annelore Sacreas, Arno Vanstapel, Janne Kaes, Vincent Geudens , et al. · 2022

Antifibrotic drugs in lung transplantation and chronic lung allograft dysfunction: a review Open

Saskia Bos, Laurens De Sadeleer, Arno Vanstapel, Hanne Beeckmans, Annelore Sacreas , et al. · 2021

This review aims to provide an overview of pre-transplant antifibrotic therapy on peri-transplant outcomes and to address the possible role of antifibrotics in lung transplant recipients with chronic lung allograft dysfunction. Lung transp…

Free Airway C4d after Lung Transplantation - A Quantitative Analysis of Bronchoalveolar Lavage Fluid Open

Tobias Heigl, Berta Sáez, Anke Van Herck, Janne Kaes, Annelore Sacreas , et al. · 2020

Lung Transplantation and Precision Medicine Open

Hanne Beeckmans, Berta Sáez, Anke Van Herck, Annelore Sacreas, Janne Kaes , et al. · 2020

Total lymphoid irradiation in progressive bronchiolitis obliterans syndrome after lung transplantation: a single‐center experience and review of literature Open

Marnix Lebeer, Janne Kaes, Maarten Lambrech, Arno Vanstapel, Hanne Beeckmans , et al. · 2019

Limited results about treatment with total lymphoid irradiation (TLI) in lung transplant (LTx) recipients suffering from progressive bronchiolitis obliterans syndrome (BOS) have been reported. We performed a retrospective analysis of all L…

Mortality after lung transplantation: a single‐centre cohort analysis Open

Jo Raskin, Arno Vanstapel, Eric Verbeken, Hanne Beeckmans, Bart Vanaudenaerde , et al. · 2019

Detailed data on postoperative death in lung transplant (LTx) recipients are lacking. Therefore, we investigated all deaths after LTx in a large, single-centre, 25-year follow-up cohort. Prevalence, time, place and cause of death (COD) wer…

Myeloid-Derived Suppressor Cells in Lung Transplantation Open

Tobias Heigl, Anurag Singh, Berta Sáez, Janne Kaes, Anke Van Herck , et al. · 2019

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage. MDSCs expand in pathological situations, such as chronic infection, cancer, autoimmunity, and allograft rejection. As chronic lung …

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