Hanne Frederiksen
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View article: Prenatal exposure to the pesticides chlorpyrifos and 2,4-Dichlorophenoxyacetic acid is associated with circulating levels of reproductive hormones in healthy infant girls
Prenatal exposure to the pesticides chlorpyrifos and 2,4-Dichlorophenoxyacetic acid is associated with circulating levels of reproductive hormones in healthy infant girls Open
In this low-exposed cohort, prenatal exposure to chlorpyrifos and 2,4-D may affect the reproductive hormones in girls, but not boys, during minipuberty, which may have long-term implications. This is of public health concern given the fact…
View article: Paracetamol (N-acetyl-para-aminophenol) disrupts early embryogenesis by cell cycle inhibition
Paracetamol (N-acetyl-para-aminophenol) disrupts early embryogenesis by cell cycle inhibition Open
STUDY QUESTION Does paracetamol (N-acetyl-para-aminophenol (APAP) also known as acetaminophen) interfere with cell division and thereby disrupt pre-implantation embryonic development? SUMMARY ANSWER Our findings suggest that APAP exposure …
View article: Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark
Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark Open
The marked seasonal variation with higher MnHxP excretions in the summer season supports the hypothesis that the recently unveiled DnHxP contamination of the UV-filter DHHB in sunscreen products could be driving these exposures.
View article: Effects of triclosan on cytokine production by human immune cells in vitro
Effects of triclosan on cytokine production by human immune cells in vitro Open
Our observations indicate a dose-dependent uptake of triclosan in PBMCs, and that triclosan enhances the cytokine secretion by LPS-stimulated PBMC, while inhibiting the pro-inflammatory response by PHA-stimulated PBMCs. Further investigati…
View article: Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes
Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes Open
View article: O-285 Reproductive hormones at 7-10 years of age in children born after assisted reproductive technology
O-285 Reproductive hormones at 7-10 years of age in children born after assisted reproductive technology Open
Study question Do reproductive hormones and pubertal development differ at 7-10 years of age in children conceived after frozen embryo transfer, fresh embryo transfer or natural conception? Summary answer Pubertal development, reproductive…
View article: Maternal urinary paracetamol concentrations and self-reported paracetamol use in mid-gestation: Association to reduced anogenital distance in Offspring from infancy to 9 years
Maternal urinary paracetamol concentrations and self-reported paracetamol use in mid-gestation: Association to reduced anogenital distance in Offspring from infancy to 9 years Open
Studies have found associations between self-reported paracetamol use during pregnancy and shorter anogenital distance (AGD) in male infants, suggesting paracetamol have antiandrogenic properties. We investigated whether self-reported para…
View article: Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort
Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort Open
Our findings suggest a negative association between maternal urinary BPA exposure and birth weight, driven by a lower birth weight in male offspring. Further research is required to explore the underlying mechanisms of BPA's possible sex-s…
View article: Adolescent acne: association to sex, puberty, testosterone and dihydrotestosterone
Adolescent acne: association to sex, puberty, testosterone and dihydrotestosterone Open
The manifestation of acne in adolescents coincides with the emergence of other androgen-dependent characteristics of puberty such as sweat odor and pubic hair. Yet, little is known about the associations with circulating levels of androgen…
View article: Extensive Exposure to Di-N-Hexyl Phthalate with Significant Seasonal Variation Across Infants, Children and Adults Including Pregnant Woman in Denmark
Extensive Exposure to Di-N-Hexyl Phthalate with Significant Seasonal Variation Across Infants, Children and Adults Including Pregnant Woman in Denmark Open
View article: Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study
Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study Open
In this large Europe-wide study, we found age/sex-specific differences between phthalate metabolites and BMI z-score, stronger in adolescents. Longitudinal studies with repeated phthalate measurements are needed.
View article: Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data – The European Joint Programme HBM4EU
Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data – The European Joint Programme HBM4EU Open
View article: Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years
Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years Open
Detailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research.
View article: Endogenous serum glucocorticoid concentrations, steroidogenic enzyme activity, and 90-day mortality in patients hospitalized with COVID-19: an observational cohort study
Endogenous serum glucocorticoid concentrations, steroidogenic enzyme activity, and 90-day mortality in patients hospitalized with COVID-19: an observational cohort study Open
In the context of severe coronavirus disease 2019 (COVID-19) illness, we examined endogenous glucocorticoid concentrations, steroidogenic enzyme activity, and their correlation with inflammation and patient outcomes. This observational stu…
View article: Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development Open
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin pathway promotes ovarian deve…
View article: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort
Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort Open
The relationship between phthalates, a group of chemical pollutants classified as endocrine disruptors, and oxidative stress is not fully understood. The aim of the present hospital-based study was to explore the associations between circu…
View article: Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU
Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU Open
View article: High incidence of imperforate vagina in ADGRA3-deficient mice
High incidence of imperforate vagina in ADGRA3-deficient mice Open
View article: Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study
Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study Open
Objective Androgens have been hypothesized to be involved in the pathophysiology of cluster headache due to the male predominance, but whether androgens are altered in patients with cluster headache remains unclear. Methods We performed a …
View article: Cohort profile: The Copenhagen Analgesic Study—The <scp>COPANA</scp> cohort
Cohort profile: The Copenhagen Analgesic Study—The <span>COPANA</span> cohort Open
Background Development of the gonads during fetal life is complex and vital for adult reproductive health. Cell and animal studies have shown an alarming effect of mild analgesics on germ cells in both males and females. More than 50% of p…
View article: Paracetamol (N-acetyl-para-aminophenol) disrupts early human embryogenesis
Paracetamol (N-acetyl-para-aminophenol) disrupts early human embryogenesis Open
It is estimated that 10–40% of all human conceptions fail around implantation 1-7 . Genetics explain ≈ 50% of early embryonic loss, leaving a substantial part of early loss without a known cause 8,9 . Smoking and alcohol are known risk fac…
View article: Ovarian follicular fluid levels of phthalates and benzophenones in relation to fertility outcomes
Ovarian follicular fluid levels of phthalates and benzophenones in relation to fertility outcomes Open
Phthalate metabolites and BP-3 were detectable in follicular fluid and high concentrations of some phthalate metabolites were linked with lower chance of successful fertility treatment outcomes. Chemical mixture concentrations in follicula…
View article: Maternal concentrations of phthalates and Attention-Deficit Hyperactivity Disorder (ADHD-) related symptoms in children aged 2 to 4 years from Odense child cohort
Maternal concentrations of phthalates and Attention-Deficit Hyperactivity Disorder (ADHD-) related symptoms in children aged 2 to 4 years from Odense child cohort Open
Maternal concentration of the low-weighted phthalate metabolite MCPP was significantly associated with a lower ADHD symptom score in children, strongest in girls. Maternal concentrations of high-molecular-weight phthalates were associated …
View article: Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe
Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe Open
Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literatu…
View article: Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11
Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11 Open
View article: Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model
Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model Open
Introduction Administration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-acti…
View article: Urinary concentration of phthalates and bisphenol A during minipuberty is associated with reproductive hormone concentrations in infant boys
Urinary concentration of phthalates and bisphenol A during minipuberty is associated with reproductive hormone concentrations in infant boys Open
Our findings indicate that exposure to chemicals with known or suspected endocrine disrupting potential, especially the EU-regulated DnBP, DEHP and BPA, may modify male reproductive hormone concentrations in infant boys suggesting that min…
View article: Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative
Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative Open
Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substi…
View article: Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021
Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021 Open
Phthalates are mainly used as plasticizers for polyvinyl chloride (PVC). Exposure to several phthalates is associated with different adverse effects most prominently on the development of reproductive functions. The HBM4EU Aligned Studies …
View article: Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)
Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021) Open