Hanno L. Tan
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View article: The impact of socioeconomic status with overall survival in hepatocellular carcinoma: a systematic review and meta-analysis
The impact of socioeconomic status with overall survival in hepatocellular carcinoma: a systematic review and meta-analysis Open
Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the second leading cause of cancer-related mortality worldwide. Patients are typically diagnosed at an advanced stage, with a poor prognosis. Despite recent…
View article: Electrocardiographic alterations in patients with emergency medical services–witnessed out-of-hospital cardiac arrest
Electrocardiographic alterations in patients with emergency medical services–witnessed out-of-hospital cardiac arrest Open
View article: Energy levels in manual defibrillation after prior AED shock
Energy levels in manual defibrillation after prior AED shock Open
Adherence to escalating energy protocol by EMS during transition from defibrillation with AED to manual defibrillator is limited. Our data did not provide evidence for a relationship between adherence and clinical outcomes.
View article: How can non-inferiority studies with mortality end points be ethically justified?
How can non-inferiority studies with mortality end points be ethically justified? Open
Background Non-inferiority (NI) studies with mortality end points are increasingly frequently conducted. They aim to show that a new treatment strategy does not entail an unacceptably higher mortality than the comparator. They raise specif…
View article: Patient and physician perspectives on smartwatch-based out-of-hospital cardiac arrest detection
Patient and physician perspectives on smartwatch-based out-of-hospital cardiac arrest detection Open
Aims The potential application of wearable technology solutions for detecting out-of-hospital cardiac arrest (OHCA) is increasingly explored to enhance survival outcomes, but questions related to device accuracy, psychological well-being, …
View article: AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block
AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block Open
Congenital complete heart block (CCHB) is a life-threatening condition in fetuses due to severe bradycardia. Maternal administration of β-adrenergic agonists is used to increase fetal heart rates, but its effectiveness is limited and lost …
View article: AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration
AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration Open
View article: Healthcare professionals’ perspectives on artificial intelligence in patient care: a systematic review of hindering and facilitating factors on different levels
Healthcare professionals’ perspectives on artificial intelligence in patient care: a systematic review of hindering and facilitating factors on different levels Open
Background Artificial intelligence (AI) applications present opportunities to enhance the diagnosis, prognosis, and treatment of various diseases. To successfully integrate and utilize AI in healthcare, it is crucial to understand the pers…
View article: Analysis of physical activity and sleep behaviour preceding malignant ventricular arrhythmias treated by implanted cardioverter-defibrillators
Analysis of physical activity and sleep behaviour preceding malignant ventricular arrhythmias treated by implanted cardioverter-defibrillators Open
Introduction Physical activity and sleep behaviors are prognostic for ventricular arrhythmias in ICD patients. However, short-term patterns in these behaviors in the days before ICD therapy remain underexplored. By analyzing accelerometer …
View article: Sex differences in out-of-hospital cardiac arrest
Sex differences in out-of-hospital cardiac arrest Open
Aims The impact of resuscitation care initiatives on sex-differences in out-of-hospital cardiac arrest (OHCA) survival remains unclear. We aim to examine sex-differences in characteristics and survival. Methods and results This Danish regi…
View article: Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community
Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community Open
Aims Adherence to an ideal cardiovascular health (CVH) might contribute to lower the burden of sudden cardiac death (SCD) in the community. We aimed to examine the association between the number of ideal CVH metrics at baseline and of its …
View article: Defining the terminology of first responders alerted for out-of-hospital cardiac arrest by medical dispatch centres: An international consensus study on nomenclature
Defining the terminology of first responders alerted for out-of-hospital cardiac arrest by medical dispatch centres: An international consensus study on nomenclature Open
This consensus study recommends using the terms "on-duty first responder" and "community first responder" to describe individuals additionally alerted by medical dispatch centres to facilitate early intervention in OHCA.
View article: Skin advanced glycation end products, indicating cumulative oxidative stress, associated with schizophrenia but not with psychosis-like experiences
Skin advanced glycation end products, indicating cumulative oxidative stress, associated with schizophrenia but not with psychosis-like experiences Open
Results indicate that excessive oxidative stress is not involved in development of PLEs, as opposed to in case of clinical psychosis.
View article: Energy Levels in Manual Defibrillation after Prior Aed Shock
Energy Levels in Manual Defibrillation after Prior Aed Shock Open
View article: Alterations in lipid, redox, and energy metabolism in recent onset psychosis: a metabolomics study in non-smoking individuals and matched controls
Alterations in lipid, redox, and energy metabolism in recent onset psychosis: a metabolomics study in non-smoking individuals and matched controls Open
View article: Associations of Clinical Characteristics With Sudden Cardiac Arrest in People With Type 2 Diabetes With and Without Cardiovascular Disease: A Longitudinal Case-Control Study Using Routine Primary Care Data
Associations of Clinical Characteristics With Sudden Cardiac Arrest in People With Type 2 Diabetes With and Without Cardiovascular Disease: A Longitudinal Case-Control Study Using Routine Primary Care Data Open
OBJECTIVE To assess longitudinal associations with sudden cardiac arrest (SCA) of clinical characteristics recorded in primary care in people with type 2 diabetes (T2D), both with and without cardiovascular disease (CVD). RESEARCH DESIGN A…
View article: <b>The associations of clinical characteristics with sudden cardiac arrest in people with type 2 diabetes with and without cardiovascular disease: a longitudinal case-control study using routine primary care data</b>
<b>The associations of clinical characteristics with sudden cardiac arrest in people with type 2 diabetes with and without cardiovascular disease: a longitudinal case-control study using routine primary care data</b> Open
Objective To assess longitudinal associations with sudden cardiac arrest (SCA) of clinical characteristics recorded in primary care in people with type 2 diabetes (T2D), both with and without cardiovascular disease (CVD).Research Design an…
View article: <b>The associations of clinical characteristics with sudden cardiac arrest in people with type 2 diabetes with and without cardiovascular disease: a longitudinal case-control study using routine primary care data</b>
<b>The associations of clinical characteristics with sudden cardiac arrest in people with type 2 diabetes with and without cardiovascular disease: a longitudinal case-control study using routine primary care data</b> Open
Objective To assess longitudinal associations with sudden cardiac arrest (SCA) of clinical characteristics recorded in primary care in people with type 2 diabetes (T2D), both with and without cardiovascular disease (CVD).Research Design an…
View article: Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest
Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest Open
BACKGROUND: In patients with out-of-hospital cardiac arrest who present with an initial shockable rhythm, a longer delay to the first shock decreases the probability of survival, often attributed to cerebral damage. The mechanisms of this …
View article: Artificial intelligence-enhanced wearable technology enables ventricular arrhythmia prediction
Artificial intelligence-enhanced wearable technology enables ventricular arrhythmia prediction Open
Background and aims Patterns in physical behaviour may be associated with an increased risk of ventricular arrhythmia. We examined associations between temporal dynamics in physical behaviour measured through wearable technology, and the r…
View article: Relationship between activity and sleep, as measured through a wearable accelerometer, and appropriate cardioverter defibrillator interventions: a prospective SafeHeart substudy
Relationship between activity and sleep, as measured through a wearable accelerometer, and appropriate cardioverter defibrillator interventions: a prospective SafeHeart substudy Open
Aims Physical activity has shown association with ventricular arrhythmia, however, the role of specific behavioral patterns over a 24 h cycle remains unknown. Therefore, we aimed to explore associations between physical behavior and approp…
View article: Lifting the Burden of Sudden Cardiac Arrest Through International Collaboration
Lifting the Burden of Sudden Cardiac Arrest Through International Collaboration Open
View article: Ethics of Wearable-Based Out-of-Hospital Cardiac Arrest Detection
Ethics of Wearable-Based Out-of-Hospital Cardiac Arrest Detection Open
Out-of-hospital cardiac arrest is a major health problem, and immediate treatment is essential for improving the chances of survival. The development of technological solutions to detect out-of-hospital cardiac arrest and alert emergency r…
View article: Long-term adherence to a wearable for continuous behavioural activity measuring in the SafeHeart implantable cardioverter defibrillator population
Long-term adherence to a wearable for continuous behavioural activity measuring in the SafeHeart implantable cardioverter defibrillator population Open
Aims Wearable health technologies are increasingly popular. Yet, wearable monitoring only works when devices are worn as intended, and adherence reporting lacks standardization. In this study, we aimed to explore the long-term adherence to…
View article: The association of depression and patient and resuscitation characteristics with survival after out-of-hospital cardiac arrest: a cohort study
The association of depression and patient and resuscitation characteristics with survival after out-of-hospital cardiac arrest: a cohort study Open
Aims Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide, with cardiovascular disease (CVD) being a key risk factor. This study aims to investigate disparities in patient/OHCA characteristics and survival after OHCA…
View article: Long-Term Socioeconomic and Mental Health Changes After Out-of-Hospital Cardiac Arrest in Women and Men
Long-Term Socioeconomic and Mental Health Changes After Out-of-Hospital Cardiac Arrest in Women and Men Open
BACKGROUND: Long-term effects of out-of-hospital cardiac arrest (OHCA) may affect the ability to work and mental health. Our aim was to analyze 5-year changes in socioeconomic and mental health outcomes after OHCA in women and men. METHODS…
View article: Incidence and Survival of Out-of-Hospital Cardiac Arrest in Public Housing Areas in 3 European Capitals
Incidence and Survival of Out-of-Hospital Cardiac Arrest in Public Housing Areas in 3 European Capitals Open
BACKGROUND: Strategies to reach out-of-hospital cardiac arrests (called cardiac arrest) in residential areas and reduce disparities in care and outcomes are warranted. This study investigated incidences of cardiac arrests in public housing…
View article: Correction: Ethical use of artificial intelligence to prevent sudden cardiac death: an interview study of patient perspectives
Correction: Ethical use of artificial intelligence to prevent sudden cardiac death: an interview study of patient perspectives Open
View article: HCN2-based biological pacing in a modified rat AV-block model
HCN2-based biological pacing in a modified rat AV-block model Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): Eurostars - Heartpace 114245 Background Electronic pacemakers have several important shortcomings which are difficult to overcome due t…
View article: Deep embedded clustering of physical behaviour in patients with an implanted cardioverter-defibrillator identifies high and low risk profiles
Deep embedded clustering of physical behaviour in patients with an implanted cardioverter-defibrillator identifies high and low risk profiles Open
Introduction Patients at high risk of sudden cardiac death are treated with an implantable cardioverter-defibrillator (ICD). Patterns in physical behaviour may be prognostic for clinical deterioration. Deep embedded clustering (DEC) employ…