Hanping Li
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View article: DNA methylation predicts adverse outcomes of coronary artery disease
DNA methylation predicts adverse outcomes of coronary artery disease Open
Adverse outcomes including myocardial infarction (MI) and stroke render coronary artery disease (CAD) a leading cause of death worldwide. DNA methylation markers may alert such adversity ahead of the events. We profiled DNA methylation of …
View article: Broadband Omnidirectional Rectenna with Integrated Solar Cell for Hybrid Energy Harvesting
Broadband Omnidirectional Rectenna with Integrated Solar Cell for Hybrid Energy Harvesting Open
This paper presents a broadband omnidirectional rectenna combined with a solar cell for hybrid energy harvesting, addressing the daytime-only limitation of solar cells via complementary RF energy harvesting. To avoid mutual interaction in …
View article: The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China
The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China Open
The HIV-1 CRF80_0107 strain has spread to cities beyond its origin, particularly the MSM population in Shenzhen city, Guangdong Province, which is an area with a high incidence of HIV. This highlights the importance of continuous monitorin…
View article: Ta<scp>NAC</scp>1 boosts powdery mildew resistance by phosphorylation‐dependent regulation of <i>TaSec1a</i> and <i>TaCAMTA4</i> via <scp>PP2A</scp>c/<scp>CDPK</scp>20
Ta<span>NAC</span>1 boosts powdery mildew resistance by phosphorylation‐dependent regulation of <i>TaSec1a</i> and <i>TaCAMTA4</i> via <span>PP2A</span>c/<span>CDPK</span>20 Open
Summary The integrity of wheat ( Triticum aestivum ) production is increasingly jeopardized by the fungal pathogen Blumeria graminis f. sp. tritici ( Bgt ), particularly amid the vicissitudes of climate change. Here, we delineated the role…
View article: Comprehensive Identification and Characterization of HML-9 Group in Chimpanzee Genome
Comprehensive Identification and Characterization of HML-9 Group in Chimpanzee Genome Open
Endogenous retroviruses (ERVs) are related to long terminal repeat (LTR) retrotransposons, comprising gene sequences of exogenous retroviruses integrated into the host genome and inherited according to Mendelian law. They are considered to…
View article: A unified classification system for HIV-1 5’ long terminal repeats
A unified classification system for HIV-1 5’ long terminal repeats Open
The HIV-1 provirus mainly consists of internal coding region flanked by 1 long terminal repeats (LTRs) at each terminus. The LTRs play important roles in HIV-1 reverse transcription, integration, and transcription. However, despite of the …
View article: Comprehensive characterization of ERV-K (HML-8) in the chimpanzee genome revealed less genomic activity than humans
Comprehensive characterization of ERV-K (HML-8) in the chimpanzee genome revealed less genomic activity than humans Open
Endogenous retroviruses (ERVs) originate from ancestral germline infections caused by exogenous retroviruses. Throughout evolution, they have become fixed within the genome of the animals into which they were integrated. As ERV elements co…
View article: DNA Methylation Predicts Adverse Outcomes of Coronary Artery Disease
DNA Methylation Predicts Adverse Outcomes of Coronary Artery Disease Open
Background Adverse outcomes including myocardial infarction and stroke render coronary artery disease (CAD) a leading cause of death worldwide. Biomarkers that predict such adversity enable closer medical supervision and opportunities for …
View article: Near full-length genome analysis of two novel HIV second recombinant forms in Hebei, China.
Near full-length genome analysis of two novel HIV second recombinant forms in Hebei, China. Open
Individuals infected with HIV-1 among men who have sex with men (MSM) rose rapidly in recent years in China, and such subtypes as CRF01_AE, CRF07_BC, B, and some novel URFs were prevalent among them. Co-circulation of strains among MSM pop…
View article: Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer
Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer Open
Colorectal cancer is one of the malignant tumors with the highest mortality rate in the world. Survival rates vary significantly among patients at various stages of the disease. A biomarker capable of early diagnosis is required to facilit…
View article: Endogenous Retrovirus Elements Are Co-Expressed with IFN Stimulation Genes in the JAK–STAT Pathway
Endogenous Retrovirus Elements Are Co-Expressed with IFN Stimulation Genes in the JAK–STAT Pathway Open
Background: Endogenous retrovirus (ERV) elements can act as proximal regulatory elements in promoting interferon (IFN) responses. Previous relevant studies have mainly focused on IFN-stimulated genes (ISGs). However, the role of ERV elemen…
View article: Limited nucleotide changes of HIV-1 subtype B Rev response element in China affect overall Rev-RRE activity and viral replication
Limited nucleotide changes of HIV-1 subtype B Rev response element in China affect overall Rev-RRE activity and viral replication Open
The HIV-1 Rev response element (RRE) is a cis-acting RNA element that facilitates the nuclear export of mRNA-containing introns by binding specifically to the Rev protein, enabling a critical step in the viral replication cycle. This study…
View article: A unified classification system for HIV-1 5’ long terminal repeats
A unified classification system for HIV-1 5’ long terminal repeats Open
The HIV-1 provirus mainly consists of internal coding region flanked by the 2 same long terminal repeats (LTRs) at each terminus. The LTRs play important roles in HIV-1 reverse transcription, integration, and transcription by the associati…
View article: Establishment and application of a method of tagged-amplicon deep sequencing for low-abundance drug resistance in HIV-1
Establishment and application of a method of tagged-amplicon deep sequencing for low-abundance drug resistance in HIV-1 Open
In the latest HIV-1 global drug resistance report released by WHO, countries are advised to strengthen pre-treatment monitoring of drug resistance in AIDS patients. In this study, we established an NGS-based segmented amplification HIV-1 d…
View article: The Origin, Application and Mechanism of Therapeutic Climbing: A Narrative Review
The Origin, Application and Mechanism of Therapeutic Climbing: A Narrative Review Open
As an innovative exercise therapy, therapeutic climbing (TC) has attracted more attention than ever before in recent years. In this review of the related studies on TC, the authors explore its origin and development; summarize its therapeu…
View article: p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity
p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity Open
Human endogenous retroviruses (HERVs) were integrated into the human genome in ancient times and have been coevolving with the host. Since the Human Genome Project, HERVs have attracted increasing attention.
View article: Human Endogenous Retroviruses and Hematological Malignant Tumors
Human Endogenous Retroviruses and Hematological Malignant Tumors Open
Human endogenous retrovirus (HERV) gene sequences are remnants of retroviruses that infected the ancestors of humans millions of years ago and were integrated into human chromosomes, accounting for approximately 8%–9% of the human genome. …
View article: High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients Open
Background. Interferon is a marker of host antiviral immunity, which is disordered in COVID-19 patients. ERV can affect the secretion of interferon through the cGAS-STING pathway. In this study, we explored whether IFN-I and HERV-K (HML-2)…
View article: Significant Upregulation of HERV-K (HML-2) Transcription Levels in Human Lung Cancer and Cancer Cells
Significant Upregulation of HERV-K (HML-2) Transcription Levels in Human Lung Cancer and Cancer Cells Open
Lung cancer is the second most common cancer worldwide and the leading cause of cancer death in the world. Therefore, there is an urgent need to develop new and effective biomarkers for diagnosis and treatment. Under this circumstance, hum…
View article: Comprehensive identification and characterization of HERV-K (HML-9) group in the human genome
Comprehensive identification and characterization of HERV-K (HML-9) group in the human genome Open
Background: Human endogenous retroviruses (HERVs) result from ancestral infections by exogenous retroviruses that became incorporated into germ-line DNA and evolutionary fixed in the human genome. HERVs could vertically transmit in a Mende…
View article: Additional file 4 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Additional file 4 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome Open
Additional file 4: Table S2. HML-9 solo LTR sequences colocalized with genes.
View article: Additional file 1 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease
Additional file 1 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease Open
Additional file 1: Table S1. Baseline characteristics on death and MACE risks. Table S2. Baseline characteristics on LVEF and LVMI. Table S3. Relationship between metabolites and death risk. Table S4. Relationship between metabolites and M…
View article: Additional file 1 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Additional file 1 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome Open
Additional file 1: Dataset S1. The nucleotide sequence of HML-9 proviral elements.
View article: Additional file 5 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Additional file 5 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome Open
Additional file 5: Table S3. The associations between each solo LTR and its putative regulated gene(s).
View article: Additional file 7 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Additional file 7 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome Open
Additional file 7: Table S5. PBS types in HML-9.