Hanping Wang
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View article: Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level
Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level Open
Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a highly metastatic tumor type, and iCCA with intrahepatic metastasis is associated with poor prognosis. Previous studies have confirmed that the tumor microenvironment (TME) i…
Proof-of-concept study of the CD39-blocking antibody JS019 in eosinophilic-associated disorders Open
Background CD39, an ectonucleotidase that hydrolyzes extracellular ATP to AMP, drives immunosuppressive adenosine accumulation and promotes Th2-dominant inflammation. Preclinical studies have shown that CD39 inhibition reduces eosinophil a…
View article: Current status of management of immune-related adverse events and practical needs for oncologist education
Current status of management of immune-related adverse events and practical needs for oncologist education Open
Immune checkpoint inhibitors have markedly improved outcomes in patients with multiple advanced malignancies. However, their widespread use has markedly increased the incidence of immune-related adverse events (irAEs). irAEs can affect a w…
View article: Bridging traditional gaps in medical training with mixed reality: insights from bronchoscopy education—a narrative review
Bridging traditional gaps in medical training with mixed reality: insights from bronchoscopy education—a narrative review Open
MR holds considerable promise for revolutionizing bronchoscopy training. As hardware costs decrease and training systems become optimized, MR is expected to be widely adopted in medical education, potentially becoming an essential or even …
View article: Gut microbiota and metabolite signatures predict severe immune-related adverse events in advanced hepatobiliary cancers
Gut microbiota and metabolite signatures predict severe immune-related adverse events in advanced hepatobiliary cancers Open
Patients with severe irAEs exhibited unique changes in microbiota-fungi-metabolite interactions. Gut microbiota- and/or metabolite-based algorithms could be used as additional tools for predicting severe irAEs and as potential prognostic m…
Successful rechallenge of immune checkpoint inhibitors after severe immune-related hepatitis, thyroiditis and hypophysitis in TMB-high NSCLC: a case report Open
This case highlights that ICI rechallenge can be a viable and effective treatment strategy in selected patients with prior high-grade irAEs, especially when initial toxicities are well controlled and alternative causes of symptoms are care…
Safety and Efficacy of the First Subcutaneous <span>ICI</span>, Envafolimab, in the Treatment of Advanced Lung Cancer Patients: A Real‐World Study Open
Background Envafolimab is a novel immune checkpoint inhibitor (ICI) with several advantages due to its subcutaneous administration. Phases I and II randomized controlled trials have demonstrated promising efficacy in treating colorectal an…
View article: Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor
Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor Open
Inflammatory myofibroblastic tumor (IMT) is a rare spindle‐cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of …
View article: Peripheral blood PD-1+ T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications
Peripheral blood PD-1+ T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications Open
A shift toward a T cell exhaustion phenotype is associated with the upregulation of expression of programmed cell death protein 1 (PD-1) on T lymphocytes in patients with malignant solid tumors. The interaction between PD-1 and programmed …
Treatment of immune checkpoint inhibitor-related colitis: a narrative review Open
Biologics are currently recommended for the treatment of ICIC but are usually used as a supplement after the failure of first-line CS therapy. Patients with irAE colitis respond favorably to biologics, and patients with CS-resistant/refrac…
Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study Open
Background Inflammatory myofibroblastic tumor (IMT) is a rare intermediate‐grade neoplasm. It presents a great challenge in diagnosis and treatment. This study aims to identify the clinicopathological characteristics of IMT. Methods A retr…
Characterization of renal injury in non‐squamous non‐small cell lung cancer patients treated with pemetrexed: A single‐center retrospective study Open
Introduction Pemetrexed is a key therapeutic agent for advanced non‐squamous non‐small cell lung cancer (Nsq‐NSCLC), yet it is associated with renal toxicity. This study aims to elucidate the incidence, risk factors, and survival impact of…
Risk Factors and Prognostic Analysis of Immune Checkpoint Inhibitor-Related Colitis in Lung Cancer Open
Immune-related colitis remains a significant concern in lung cancer patients treated with ICIs and requires close monitoring and timely intervention. Restarting treatment after symptom relief can provide additional benefits for patients.
View article: Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma
Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma Open
Background The association between gut bacteria and the response to immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC) has been studied; however, multi-kingdom gut microbiome alterations and interactions in ICI-treated HC…
Key Roles of Initial Calcination Temperature in Accelerating the Performance in Proton Ceramic Fuel Cells via Regulating 3D Microstructure and Electronic Structure Open
Developing cathode materials with high performance in oxygen reduction reaction (ORR) is desirable for proton ceramic fuel cells (PCFCs) for energy conversion technology. BaCo 0.4 Fe 0.4 Zr 0.1 Y 0.1 O 3–δ (BCFZY) is widely investigated as…
View article: Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma
Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma Open
In this paper, H-ChC was explored, hoping to contribute to the study of mixed tumours in other cancers.
View article: Identification of protein signatures for lung cancer subtypes based on BPSO method
Identification of protein signatures for lung cancer subtypes based on BPSO method Open
The objective of this study was to identify protein biomarkers that can distinguish between LUAD and LUSC, critical for personalized treatment plans. The proteomic profiling data of LUAD and LUSC samples from TCPA database, along with phen…
Analysis of cytokines in bronchoalveolar lavage fluid in patients with checkpoint inhibitor pneumonitis and pulmonary infection: A case–control study Open
Background The discovery of immune checkpoint inhibitors (ICIs) is a breakthrough in the field of cancer therapy. However, ICIs may cause immune‐related adverse reactions, including checkpoint inhibitor‐related pneumonitis (CIP). The aim o…
Measurement of sarcopenia in lung cancer inpatients and its association with frailty, nutritional risk, and malnutrition Open
Background Sarcopenia, frailty, and malnutrition are associated with undesirable clinical outcomes in cancer patients. Sarcopenia-related measurements may be promising fast biomarkers for frailty. Our objectives were to assess the prevalen…
Camrelizumab plus platinum-irinotecan followed by maintenance camrelizumab plus apatinib in untreated extensive-stage small-cell lung cancer: a nonrandomized clinical trial Open
Background Programmed cell death-ligand 1 (PD-L1) inhibitors plus chemotherapy have made substantial progress in extensive-stage small-cell lung cancer (ES-SCLC), but the survival benefit is still limited. This study aimed to evaluate the …
Savolitinib versus crizotinib for treating <span>MET</span> positive non‐small cell lung cancer Open
Background The c‐MET protein, encoded by the mesenchymal‐epithelial transition factor (MET) gene, can regulate cell proliferation, migration and invasion. Studies have shown that it is one of the essential driver genes for non‐small cell l…