Hanrong Chen
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View article: Assessing Zoonotic Risks of Blastocystis Infection in Singapore
Assessing Zoonotic Risks of Blastocystis Infection in Singapore Open
Blastocystis spp. is an enteric protist that is present worldwide. Despite being discovered a century ago, there is still much to be learned about its pathogenicity and transmission. Different subtypes (ST) of Blastocystis spp. have been i…
View article: Floria: fast and accurate strain haplotyping in metagenomes
Floria: fast and accurate strain haplotyping in metagenomes Open
Summary Shotgun metagenomics allows for direct analysis of microbial community genetics, but scalable computational methods for the recovery of bacterial strain genomes from microbiomes remains a key challenge. We introduce Floria, a novel…
View article: Floria: Fast and accurate strain haplotyping in metagenomes
Floria: Fast and accurate strain haplotyping in metagenomes Open
Shotgun metagenomics allows for direct analysis of microbial community genetics, but scalable computational methods for the recovery of bacterial strain genomes from microbiomes remains a key challenge. We introduce Floria, a novel method …
View article: Dominant Carbapenemase-Encoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent <i>Klebsiella pneumoniae</i>, Singapore
Dominant Carbapenemase-Encoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent <i>Klebsiella pneumoniae</i>, Singapore Open
Dissemination of carbapenemase-encoding plasmids by horizontal gene transfer in multidrug-resistant bacteria is the major driver of rising carbapenem-resistance, but the conjugative mechanics and evolution of clinically relevant plasmids a…
View article: A scaling law in CRISPR repertoire sizes arises from the avoidance of autoimmunity
A scaling law in CRISPR repertoire sizes arises from the avoidance of autoimmunity Open
Some prokaryotes possess CRISPR-Cas systems that use DNA segments called spacers, which are acquired from invading phages, to guide immune defense. Here, we propose that cross-reactive CRISPR targeting can, however, lead to "heterologous a…
View article: inPhocus: Current State and Challenges of Phage Research in Singapore
inPhocus: Current State and Challenges of Phage Research in Singapore Open
Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, …
View article: Heterologous autoimmunity and prokaryotic immune defense
Heterologous autoimmunity and prokaryotic immune defense Open
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incidence and limited memory breadth of CRISPR-Cas systems sugges…
View article: Heterologous autoimmunity and prokaryotic immune defense
Heterologous autoimmunity and prokaryotic immune defense Open
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incidence and limited memory breadth of CRISPR-Cas systems sugges…
View article: Heterologous autoimmunity and prokaryotic immune defense
Heterologous autoimmunity and prokaryotic immune defense Open
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to\nviruses guided by DNA segments called spacers acquired from invading phage.\nHowever, the patchy incidence and limited memory breadth of CRISPR-Cas systems\nsug…
View article: Mean-field computational approach to HIV dynamics on a fitness landscape
Mean-field computational approach to HIV dynamics on a fitness landscape Open
During infection by the human immunodeficiency virus (HIV), mutations accumulate in the intra-host viral population due to selection imposed by host T cell responses. The timescales at which HIV residues acquire mutations in a host range f…
View article: Statistical Physics, Evolutionary Dynamics of HIV, and the Adaptive Immune System
Statistical Physics, Evolutionary Dynamics of HIV, and the Adaptive Immune System Open
Humans and other vertebrate hosts possess an adaptive immune system that defends the host against infection by a plethora of pathogens in a specific, targeted manner. T cells are an important arm of the adaptive immune system, and kill vir…
View article: How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes
How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes Open
T cell receptors (TCRs) bind foreign or self-peptides attached to major histocompatibility complex (MHC) molecules, and the strength of this interaction determines T cell activation. Optimizing the ability of T cells to recognize a diversi…
View article: How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes
How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes Open
T cell receptors (TCRs) bind foreign or self-peptides attached to major histocompatibility complex (MHC) molecules, and the strength of this interaction determines T cell activation. Optimizing the ability of T cells to recognize a diversi…
View article: A Study on the Role of MOOCs in Computer Basic Teaching in Universities
A Study on the Role of MOOCs in Computer Basic Teaching in Universities Open
MOOC in China is developing rapidly, we will curtain into the university computer basic course teaching.It is found that there are some limitations in the process of computer basic teaching in the university.Through the intervention and gu…