Hans C. Leier YOU? Author Swipe

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Selective life-long suppression of an odor processing channel in response to critical period experience Open

Hans C. Leier, Julius Jonaitis, Alexander J Foden, Abigail J Wilkov, Annika E Ross , et al. · 2025

Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…

Selective life-long suppression of an odor processing channel in response to critical period experience Open

Hans C. Leier, Julius Jonaitis, Alexander J Foden, Abigail J Wilkov, Annika E Ross , et al. · 2025

Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…

Selective life-long suppression of an odor processing channel in response to critical period experience Open

Hans C. Leier, Julius Jonaitis, Alexander J Foden, Abigail J Wilkov, Annika E Ross , et al. · 2025

Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…

Author response: Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2025

Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2025

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Dros…

Author response: Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2025

Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2025

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Dros…

Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2024

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Dros…

Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2024

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Dros…

Glia control experience-dependent plasticity in an olfactory critical period Open

Hans C. Leier, Alex J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello , et al. · 2024

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Dros…

Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe Open

Darren A Jindal, Hans C. Leier, Gabriela Salazar, Alexander J Foden, Elizabeth A. Seitz , et al. · 2023

Glial phagocytic activity refines connectivity, though molecular mechanisms regulating this exquisitely sensitive process are incompletely defined. We developed the Drosophila antennal lobe as a model for identifying molecular mechanisms u…

An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants Open

Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Devin Schoen, Zoë L. Lyski , et al. · 2023

As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be important globally. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of novel variants has created a m…

The time between vaccination and infection impacts immunity against SARS-CoV-2 variants Open

Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Devin Schoen, Zoë L. Lyski , et al. · 2023

As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be globally important. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of novel variants have created a …

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants Open

Scotland Farley, Jennifer Kyle, Hans C. Leier, Lisa Bramer, Jules B. Weinstein , et al. · 2022

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants Open

Jules B. Weinstein, Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Eric Barklis , et al. · 2022

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants Open

Scotland Farley, Jennifer Kyle, Hans C. Leier, Lisa Bramer, Jules B. Weinstein , et al. · 2022

A comprehensive understanding of host dependency factors for SARS-CoV-2 remains elusive. We mapped alterations in host lipids following SARS-CoV-2 infection using nontargeted lipidomics. We found that SARS-CoV-2 rewires host lipid metaboli…

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants Open

Timothy A. Bates, Savannah K. McBride, Hans C. Leier, Gaelen Guzman, Zoë L. Lyski , et al. · 2022

Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity and mortality and are vitally important to controlling the pandemic. Individuals who previously recovered from COVID-19 have enhanced immune response…

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants Open

Jules B. Weinstein, Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Eric Barklis , et al. · 2022

The spike glycoprotein of SARS-CoV-2 engages with human angiotensin-converting enzyme 2 (ACE2) to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by com…

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants Open

Richard B. van Breemen, Ruth N. Muchiri, Timothy A. Bates, Jules B. Weinstein, Hans C. Leier , et al. · 2022

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectr…

Source data for Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum Open

Timothy A. Bates, Hans C. Leier, Zoë L. Lyski, Savannah K. McBride, Felicity J. Coulter , et al. · 2021

This dataset contains the source data used in the publication: "Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum" published in Nature communications on August 26, 2021 (10.1038/s41467-021-25479-6).

Source data for Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum Open

Timothy A. Bates, Hans C. Leier, Zoë L. Lyski, Savannah K. McBride, Felicity J. Coulter , et al. · 2021

This dataset contains the source data used in the publication: "Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum" published in Nature communications on August 26, 2021 (10.1038/s41467-021-25479-6).

Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum Open

Timothy A. Bates, Hans C. Leier, Zoë L. Lyski, Savannah K. McBride, Felicity J. Coulter , et al. · 2021

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples Open

Timothy A. Bates, Hans C. Leier, Zoë L. Lyski, James R. Goodman, Marcel E. Curlin , et al. · 2021

This study examines the relationship between age and neutralizing antibody titers against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after 2 doses of the BNT162b2 vaccine.

Previously infected vaccinees broadly neutralize SARS-CoV-2 variants Open

Hans C. Leier, Timothy A. Bates, Zoë L. Lyski, Savannah K. McBride, David X. Lee , et al. · 2021

We compared the serum neutralizing antibody titers before and after two doses of the BNT162b2 COVID-19 vaccine in ten individuals who recovered from SARS-CoV-2 infection prior to vaccination to 20 individuals with no history of infection, …

Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum Open

Timothy A. Bates, Hans C. Leier, Zoë L. Lyski, Savannah K. McBride, Felicity J. Coulter , et al. · 2021

We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more p…

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2 Open

Timothy A. Bates, Jules B. Weinstein, Scotland Farley, Hans C. Leier, William B. Messer , et al. · 2021

Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry Open

Patrick Niekamp, Gaelen Guzman, Hans C. Leier, Ali Rashidfarrokhi, Veronica Richina , et al. · 2021

Mycobacterium tuberculosis ( Mtb ) invades alveolar macrophages through phagocytosis to establish infection and cause disease. The molecular mechanisms underlying Mtb entry are still poorly understood.

Ceramide synthase 2 deletion decreases the infectivity of HIV-1 Open

Eric Barklis, Ayna Alfadhli, Jennifer Kyle, Lisa Bramer, Kent Bloodsworth , et al. · 2021

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2 Open

Timothy A. Bates, Jules B. Weinstein, Scotland Farley, Hans C. Leier, William B. Messer , et al. · 2020

There is currently a lack of biological tools to study the replication cycle and pathogenesis of SARS-CoV-2, the etiological agent of COVID-19. Repurposing the existing tools, including antibodies of SARS-CoV, is an effective way to accele…

A global lipid map defines a network essential for Zika virus replication Open

Hans C. Leier, Jules B. Weinstein, Jennifer Kyle, Joon‐Yong Lee, Lisa Bramer , et al. · 2020

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