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View article: Locally advanced breast cancer: primary ultra-hypofractionated radiotherapy for inoperable or frail patients
Locally advanced breast cancer: primary ultra-hypofractionated radiotherapy for inoperable or frail patients Open
Purpose Locally advanced breast cancer in frail and inoperable patients often causes tumor-associated pain, bleeding, or discharge. These patients may not be suitable for therapeutic options like surgery or potentially toxic systemic treat…
View article: Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation
Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation Open
Introduction Circulating soluble fibroblast activation protein (FAP) is implicated in myocardial infarction, stroke, fibrosis and various cancers. This study investigates changes in FAP concentrations in patients with intra-thoracic malign…
View article: Breast Edema After Breast-Conserving Surgery and Radiotherapy: Introduction of a Clinically Meaningful Classification and Evaluation of the Incidence After Normo- and Hypofractionated Treatments
Breast Edema After Breast-Conserving Surgery and Radiotherapy: Introduction of a Clinically Meaningful Classification and Evaluation of the Incidence After Normo- and Hypofractionated Treatments Open
BE following RT after breast-conserving surgery is a common concern, impacting patients’ quality of life. This study introduces a clinically meaningful classification system for BE and retrospectively evaluates its incidence among patients…
View article: Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma
Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma Open
The guideline is being drawn up as a joint guideline for oropharyngeal and hypopharyngeal carcinoma. Oropharyngeal carcinoma in particular has experienced the greatest increase in incidence among all head and neck carcinomas in the last 20…
View article: Radiation Treatment Planning After Minimum Metallic Instrumentation for Patients with Spinal Metastases: A Case Series
Radiation Treatment Planning After Minimum Metallic Instrumentation for Patients with Spinal Metastases: A Case Series Open
Background and Objectives: The utilization of non-metallic pedicle screws and rods has become a favored approach in the management of spinal tumors. An abundance of metal artifacts improves postoperative imaging and allows for precise radi…
View article: Radiotherapy in patients with brain metastases with and without concomitant immunotherapy: comparison of patient outcome and neurotoxicity
Radiotherapy in patients with brain metastases with and without concomitant immunotherapy: comparison of patient outcome and neurotoxicity Open
Background/Aim Recently, immune checkpoint inhibitors (ICI) have been added to the treatment of brain metastases. While combining radiotherapy and ICI can enhance therapeutic effects, it might also increase the risk of severe autoimmune ad…
View article: Is intensive training with a time interval between instruction and planning CT necessary for deep inspiration breath-hold radiotherapy in breast cancer?
Is intensive training with a time interval between instruction and planning CT necessary for deep inspiration breath-hold radiotherapy in breast cancer? Open
Background Breathing instruction and exercises and a time gap between training and planning CT scans (pCT) is recommended as part of deep inspiration breath-hold (DIBH) assisted radiotherapy (RT). However, this is associated with additiona…
View article: Palliative Einsatzgebiete der Strahlentherapie und Blutungskontrolle beim Magenkarzinom
Palliative Einsatzgebiete der Strahlentherapie und Blutungskontrolle beim Magenkarzinom Open
Magenkarzinome gehören zu den 5 häufigsten Krebsneudiagnosen weltweit und sind aufgrund fehlender Frühsymptome häufig schon bei Erstdiagnose im inkurablen Stadium. Die Symptomatik im Bereich des Primarius (Blutungen, Stenose, Schmerzen) al…
View article: Efficiency of moderately hypofractionated radiotherapy in NSCLC cell model
Efficiency of moderately hypofractionated radiotherapy in NSCLC cell model Open
Background The current standard of radiotherapy for inoperable locally advanced NSCLCs with single fraction doses of 2.0 Gy, results in poor outcomes. Several fractionation schedules have been explored that developed over the past decades …
View article: Determining the Appropriateness and Acceptability of a Reduced Postradiotherapy Surveillance Practice in Breast Cancer Patients: Results of a Longitudinal Observational Study
Determining the Appropriateness and Acceptability of a Reduced Postradiotherapy Surveillance Practice in Breast Cancer Patients: Results of a Longitudinal Observational Study Open
Postradiotherapy surveillance, which aims to detect and treat radiation injury, is important from the patient’s perspective, but also from the radiation oncologist’s perspective. Unfortunately, patient nonattendance increases over the cour…
View article: Combination of nivolumab with standard induction chemotherapy in children and adults with EBV-positive nasopharyngeal carcinoma
Combination of nivolumab with standard induction chemotherapy in children and adults with EBV-positive nasopharyngeal carcinoma Open
Background Treatment of Epstein-Barr virus(EBV)-positive nasopharyngeal carcinoma (NPC) with cisplatin/5-fluorouracil (5-FU) induction chemotherapy, followed by radiochemotherapy and subsequent interferon‑β, has yielded high survival rates…
View article: Successful implementation of online educational lectures of the German Society for Radiation Oncology (DEGRO)
Successful implementation of online educational lectures of the German Society for Radiation Oncology (DEGRO) Open
Purpose Modern digital teaching formats have become increasingly important in recent years, in part due to the COVID-19 pandemic. In January 2021, an online-based webinar series was established by the German Society for Radiation Oncology …
View article: Influence of demographic change on the demand for radiotherapy using forecasted predictions for prostate cancer in Germany
Influence of demographic change on the demand for radiotherapy using forecasted predictions for prostate cancer in Germany Open
View article: Low skeletal muscle mass is predictive of dose-limiting toxicities in head and neck cancer patients undergoing low-dose weekly cisplatin chemoradiotherapy
Low skeletal muscle mass is predictive of dose-limiting toxicities in head and neck cancer patients undergoing low-dose weekly cisplatin chemoradiotherapy Open
Background The dose-limiting effect of CT-assessed low skeletal muscle mass (LSMM) measured at the level of the third cervical vertebra has been found in head and neck cancer patients receiving high-dose cisplatin chemoradiotherapy. The ai…
View article: Using a Further Planning MRI after Neoadjuvant Androgen Deprivation Therapy Significantly Reduces the Radiation Exposure of Organs at Risk in External Beam Radiotherapy of Prostate Cancer
Using a Further Planning MRI after Neoadjuvant Androgen Deprivation Therapy Significantly Reduces the Radiation Exposure of Organs at Risk in External Beam Radiotherapy of Prostate Cancer Open
Radiotherapy for prostate cancer is often preceded by neoadjuvant androgen deprivation therapy (ADT), which leads to a reduction in the size of the prostate. This study examines whether it is relevant for treatment planning to acquire a se…
View article: Effectiveness of hypofractionated and normofractionated radiotherapy in a triple‐negative breast cancer model
Effectiveness of hypofractionated and normofractionated radiotherapy in a triple‐negative breast cancer model Open
Breast cancer (BC) is one of the most diagnosed malignant carcinomas in women with a triple-negative breast cancer (TNBC) phenotype being correlated with poorer prognosis. Fractionated radiotherapy (RT) is a central component of breast can…
View article: Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy
Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy Open
View article: The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer
The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer Open
To assess the prognostic value of “liquid biopsies” for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having a…
View article: Endokrine Tumoren
Endokrine Tumoren Open
View article: Hypofraktionierte Strahlentherapie – ein modernisierter Klassiker
Hypofraktionierte Strahlentherapie – ein modernisierter Klassiker Open
Zusammenfassung Die Nutzung unterschiedlicher Fraktionierungskonzepte in der Strahlentherapie ist seit über 100 Jahren Gegenstand der präklinischen und klinischen Forschung. Als Hypofraktionierung bezeichnet man dabei die Nutzung höherer E…
View article: Lessons learned after one year of COVID-19 from a urologist and radiotherapist view: A German survey on prostate cancer diagnosis and treatment
Lessons learned after one year of COVID-19 from a urologist and radiotherapist view: A German survey on prostate cancer diagnosis and treatment Open
Introduction Since the beginning of the pandemic in 2020, COVID-19 has changed the medical landscape. International recommendations for localized prostate cancer (PCa) include deferred treatment and adjusted therapeutic routines. Materials…
View article: Phase-II-Studie zur Therapiedeeskalation bei HPV-assoziierten Oropharynxkarzinomen. Kommentar II
Phase-II-Studie zur Therapiedeeskalation bei HPV-assoziierten Oropharynxkarzinomen. Kommentar II Open
View article: Radiotherapy of Breast Cancer in Laterally Tilted Prone vs. Supine Position: What about the Internal Mammary Chain?
Radiotherapy of Breast Cancer in Laterally Tilted Prone vs. Supine Position: What about the Internal Mammary Chain? Open
Background: In the multimodal breast-conserving curative therapy of some high-risk breast cancer patients, extended external beam radiotherapy (EBRT) not only to the breast but also to the supraclavicular fossa and the internal mammary cha…
View article: Neoadjuvant versus definitive radiochemotherapy of locoregionally advanced oesophageal cancer—who benefits?
Neoadjuvant versus definitive radiochemotherapy of locoregionally advanced oesophageal cancer—who benefits? Open
View article: Restoring the dynamism of Malaysia’s business sector
Restoring the dynamism of Malaysia’s business sector Open
Before the COVID-19 pandemic, Malaysia undertook a series of vigorous reforms, ranging from the improvement of regulatory framework to the digitalisation of the economy, with the aim of boosting productivity. While the protracted pandemic …
View article: Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort
Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort Open
Nasopharyngeal carcinoma (NPC) in children and young adults has been treated within two consecutive prospective trials in Germany, the NPC-91 and the NPC-2003 study of the German Society of Pediatric Oncology and Hematology (GPOH). In thes…
View article: Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes
Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes Open
IMPORTANCE: Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precise contributions to different disease subtypes are unclear. This information is relevant to guidelines for ge…
View article: The Fusion of MRI and CT in the Planning of Brachytherapy for Cancer of the Uterine Cervix
The Fusion of MRI and CT in the Planning of Brachytherapy for Cancer of the Uterine Cervix Open
Introduction: tumors of the uterine cervix are among the most common carcinomas in women. Intracervical brachytherapy is an indispensable part of curative treatment. Although the tumor is significantly more recognizable in MRI than in CT, …
View article: Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient data
Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient data Open
Objective To assess the change in inpatient radiotherapy related to COVID-19 lockdown measures during the first wave of the pandemic in 2020. Methods We included cases hospitalized between January 1 and August 31, 2018–2020, with a primary…
View article: Moderately Hypofractionated Radiotherapy Without Chemotherapy in Elderly or Frail Patients With Head and Neck Cancer
Moderately Hypofractionated Radiotherapy Without Chemotherapy in Elderly or Frail Patients With Head and Neck Cancer Open
HRT in elderly/frail patients with HNSCC who are unfit for chemotherapy leads to acceptable local control with moderate toxicity in a short overall treatment time. Especially in the postoperative situation, HRT can be considered an appropr…