Hans Jürgen Hoffmann
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Acceptability and feasibility of a need-supportive intervention to increase trial retention: a randomised feasibility study within a randomised controlled allergy trial in Denmark Open
Introduction Given that low retention rates are a prevalent challenge in clinical trials, which ultimately affects trial validity, it is recommended that interventions be developed and evaluated to increase trial retention. In the context …
Understanding the combined symptom medication score in the light of contexts and mechanisms Open
Background In a clinical trial of allergen‐specific immunotherapy for allergic rhinoconjunctivitis, the Combined Symptom Medication Score (CSMS) was utilized as the primary endpoint. This was aligned with the European Academy of Allergy an…
Basophil FceRI expression—A management tool in anti‐IgE treatment of allergic asthma Open
Background Immune‐based therapy targeting immunoglobulin E (IgE), anti‐IgE treatment, has emerged as an adjunct treatment for children with severe allergic asthma. After start of anti‐IgE treatment, an effect of the treatment cannot be mon…
View article: How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound‐guided injections
How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound‐guided injections Open
Background Intralymphatic immunotherapy (ILIT) represents a promising novel approach treating allergic diseases. However, no standardized procedures or recommendations have been established or reported, despite the recognized fact that tre…
A five-gene qPCR signature can classify type 2 asthma comparably to microscopy of induced sputum from severe asthma patients Open
This study confirms the contribution of mast cells in the pathogenesis of EA and suggests that mast cell mRNA markers could be one of the biomarkers used to identify EA.
Flow‐based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper Open
Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mir…
<span>EAACI</span> task force report: A consensus protocol for the basophil activation test for collaboration and external quality assurance Open
To the editor The basophil activation test (BAT) has significant potential as a diagnostic tool to better phenotype and manage patients with IgE-mediated allergies, so that only a small proportion of patients need to be challenged. Sample,…
View article: EUFOREA summit in Brussels 2023: inspiring the future of allergy & respiratory care
EUFOREA summit in Brussels 2023: inspiring the future of allergy & respiratory care Open
In March 2023, the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi-annual Summit in Brussels with expert panel members of EUFOREA, representatives of the EUFOREA patient advisory board, …
Evidence of kinetic proofreading through allergen specific IgE at the human mast cell IgE receptor Open
Background Activation of mast cells through IgE results in secretion and shedding of mast cell proteins and in vivo models suggest that these processes are governed by IgE antibody affinity. Methods We passively sensitized cultured primary…
View article: <scp>EAACI</scp>Molecular Allergology User's Guide 2.0
<span>EAACI</span>Molecular Allergology User's Guide 2.0 Open
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response…
Ultrasound‐guided intralymphatic immunotherapy: A single‐center trial of a clinical skills training programme Open
Relevant symptom-reducing effect of intra-lymphatic immunotherapy, ILIT, previously found in clinical trials1 has recently been reviewed.2 The review contains three meta-analyses; one found ILIT safe but not effective, whereas two studies …
A consensus protocol for the Basophil Activation Test for multicenter collaboration and External Quality Assurance Open
A consensus protocol for the Basophil Activation Test for multicenter collaboration and External Quality AssuranceAuthors: Pascal, M# 1, Edelman SM#2, Nopp, A#3, Möbs, C4, Geilenkeuser, WJ5, Knol, EF6, Ebo, DG7, Mertens C7, Shamji, MH8, Sa…
Growing Through Value-Driven Leadership Open
Speaking on behalf of the SMPTE Board and the Society as a whole, I can say that we all deeply appreciate Barbara’s value-driven leadership over the past 12 years and the many significant contributions she has made to SMPTE. Barbara’s visi…
View article: COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations
COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations Open
Immune modulation is a key therapeutic tool for allergic diseases and asthma. It can be achieved in an antigen-specific way via allergen immunotherapy (AIT) or in endotype-driven approach using biologicals that target the major pathways of…
View article: Management of anaphylaxis due to COVID‐19 vaccines in the elderly
Management of anaphylaxis due to COVID‐19 vaccines in the elderly Open
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID‐19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID‐19 v…
Allergen immunotherapy: The growing role of observational and randomized trial “Real‐World Evidence” Open
Background Although there is a considerable body of knowledge about allergen immunotherapy (AIT), there is a lack of data on the reliability of real‐world evidence (RWE) in AIT, and consequently, a lack of information on how AIT effectivel…
Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice Open
The basophil activation test (BAT) is a functional assay that measures the degree of degranulation following stimulation with allergen or controls by flow cytometry. It correlates directly with histamine release. From the dose‐response cur…
Allergen immunotherapy: the growing role of observational and randomised trial “real-world evidence” Open
Although there is a considerable body of knowledge about allergen immunotherapy (AIT), there is a lack of data on the reliability of real-world evidence (RWE) in AIT and consequently, a lack of information on how AIT effectively works in r…
Newly Elected Officers and Governors Open
Congratulations to all the newly elected officers and governors who will serve a two-year term starting 2021–2022.
Transitions of electrons and holes drive diffusion in crystals, glasses and melts Open
Diffusion of atoms or molecules (generally: particles) is driven by differences and gradients of the chemical potential of the particles in their accessible space. If the difference of the chemical potential is due to differences of concen…