Hans J. Baelde
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View article: Spatial Transcriptomics Reveals Injured Cells, Signature Genes, and Communication Patterns in the Cyst Microenvironment of Polycystic Kidney Disease
Spatial Transcriptomics Reveals Injured Cells, Signature Genes, and Communication Patterns in the Cyst Microenvironment of Polycystic Kidney Disease Open
Key Points Myofibroblasts and injury repair–related cell types were exclusively observed in polycystic kidney disease and enriched within the cyst microenvironment. Cyst-associated gene signature of 45 genes with decreased expression furth…
View article: Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function
Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function Open
Long noncoding RNAs (lncRNAs) play essential roles in cellular processes, often exhibiting cell type–specific expression and influencing kidney function. While single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellul…
View article: <b>Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function</b>
<b>Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function</b> Open
Long non-coding RNAs (lncRNAs) play essential roles in cellular processes, often exhibiting cell type-specific expression and influencing kidney function. While single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellu…
View article: <b>Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function</b>
<b>Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function</b> Open
Long non-coding RNAs (lncRNAs) play essential roles in cellular processes, often exhibiting cell type-specific expression and influencing kidney function. While single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellu…
View article: A Study on the Distribution of BK and JC polyomavirus in discarded donor kidneys
A Study on the Distribution of BK and JC polyomavirus in discarded donor kidneys Open
View article: Author Correction: Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing
Author Correction: Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing Open
View article: The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages Open
Background Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in preeclampsia. sFLT1 also reduces chronic inflammation and promotes tissue repair. In experimental diabetic ne…
View article: Identification of transcription factors that regulate placental sFLT1 expression
Identification of transcription factors that regulate placental sFLT1 expression Open
Increased soluble FMS-like tyrosine kinase 1 (sFLT1) levels have been associated with preeclampsia, chronic kidney diseases, and kidney transplant rejection. However, lower levels of sFLT1 exhibit beneficial properties in various processes…
View article: Recurrent <i>CLTC</i>::<i>SYK</i> fusions and <i>CSF1R</i> mutations in juvenile xanthogranuloma of soft tissue
Recurrent <i>CLTC</i>::<i>SYK</i> fusions and <i>CSF1R</i> mutations in juvenile xanthogranuloma of soft tissue Open
Juvenile xanthogranuloma (JXG) is a histiocytic neoplasm that usually presents in the skin. Rarely, extracutaneous localizations occur; the genetic drivers of this clinical variant of JXG remain incompletely characterized. We present detai…
View article: Rapid liquid biopsy assessment through gene profiling from the kidney biopsy transport medium: a technical validation and a proof-of-concept pilot study
Rapid liquid biopsy assessment through gene profiling from the kidney biopsy transport medium: a technical validation and a proof-of-concept pilot study Open
Background Rapid diagnosis is pivotal in kidney disease for timely and targeted treatment. Conventional microscopic and molecular assessments from biopsy tissues rely on extra sample processing (e.g., formalin-fixation, paraffin-embedding …
View article: Antisense oligonucleotide-mediated terminal intron retention of endoglin: A potential strategy to inhibit renal interstitial fibrosis
Antisense oligonucleotide-mediated terminal intron retention of endoglin: A potential strategy to inhibit renal interstitial fibrosis Open
TGF-β is considered an important cytokine in the development of interstitial fibrosis in chronic kidney disease. The TGF-β co-receptor endoglin (ENG) tends to be upregulated in kidney fibrosis. ENG has two membrane bound isoforms generated…
View article: Bi-allelic NIT1 variants cause a brain small vessel disease characterized by movement disorders, massively dilated perivascular spaces, and intracerebral hemorrhage
Bi-allelic NIT1 variants cause a brain small vessel disease characterized by movement disorders, massively dilated perivascular spaces, and intracerebral hemorrhage Open
NIT1-small vessel disease is a novel, autosomal recessively inherited cerebral small vessel disease characterized by a triad of movement disorders, massively dilated basal ganglia perivascular spaces, and intracerebral hemorrhage.
View article: Transcriptomic profiling of Polycystic Kidney Disease identifies paracrine factors in the early cyst microenvironment
Transcriptomic profiling of Polycystic Kidney Disease identifies paracrine factors in the early cyst microenvironment Open
Initial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding tissue and trigger a cystic snowball effect, in which local aberrant PKD-related signaling increases the likelihood of new cyst formation, ultimat…
View article: Transmembrane protein <scp>14A</scp> protects glomerular filtration barrier integrity
Transmembrane protein <span>14A</span> protects glomerular filtration barrier integrity Open
Transmembrane protein 14A (TMEM14A) is a relatively unknown protein that is now identified to be required for maintaining the integrity of the glomerular filtration barrier. It is an integral transmembrane protein of 99 amino acids with th…
View article: Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis
Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis Open
Messenger RNA (mRNA) therapies are emerging in different disease areas, but have not yet reached the kidney field. Our aim was to study the feasibility to treat the genetic defect in cystinosis using synthetic mRNA in cell models and ctns …
View article: Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease Open
Metabolic reprogramming is a driver of autosomal dominant polycystic kidney disease (ADPKD) progression and a potential therapeutic intervention route. We showed before that the AMP-associated protein kinase (AMPK) activator salsalate atte…
View article: Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis
Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis Open
View article: MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia
MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia Open
Insufficient immune tolerance during pregnancy is associated with pathological conditions such as preeclampsia (PE). Soluble fms-like tyrosine kinase-1 (sFLT1), which exerts a role in the late stage of PE, has shown its beneficial anti-inf…
View article: Bi-allelic<i>NIT1</i>variants cause small vessel disease with movement disorders and massive non-lobar intracerebral haemorrhage
Bi-allelic<i>NIT1</i>variants cause small vessel disease with movement disorders and massive non-lobar intracerebral haemorrhage Open
Highly penetrant monogenic causes of intracerebral haemorrhage are rare, and are almost exclusively hereditary cerebral amyloid angiopathies caused by heterozygous pathogenic variants in the APP gene. Here, we identified a novel genetic ca…
View article: Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging
Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging Open
Leptin is a hormone that plays a key role in controlling food intake and energy homeostasis. Skeletal muscle is an important target for leptin and recent studies have shown that leptin deficiency may lead to muscular atrophy. However, lept…
View article: Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis
Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis Open
Multiple sclerosis (MS) pathology features autoimmune-driven neuroinflammation, demyelination, and failed remyelination. Carnosine is a histidine-containing dipeptide (HCD) with pluripotent homeostatic properties that is able to improve ou…
View article: No <i>NFATC2</i> fusion in simple bone cyst of the jaw
No <i>NFATC2</i> fusion in simple bone cyst of the jaw Open
Aims Simple Bone Cysts (SBCs) predominantly occur in long bones and 59% harbour NFATC2 rearrangements. Jaw SBC is rare and was previously referred to as traumatic bone cyst. It can rarely occur in association with cemento‐osseous dysplasia…
View article: Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement
Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement Open
View article: Endoglin Is an Important Mediator in the Final Common Pathway of Chronic Kidney Disease to End-Stage Renal Disease
Endoglin Is an Important Mediator in the Final Common Pathway of Chronic Kidney Disease to End-Stage Renal Disease Open
Chronic kidney disease (CKD) is a slow-developing, progressive deterioration of renal function. The final common pathway in the pathophysiology of CKD involves glomerular sclerosis, tubular atrophy and interstitial fibrosis. Transforming g…
View article: The severity of chronic histiocytic intervillositis is associated with gestational age and fetal weight
The severity of chronic histiocytic intervillositis is associated with gestational age and fetal weight Open
More severe intervillous infiltrates in CHI placentas is associated with a lower birth weight and placental weight. Furthermore, this study proposes thrombomodulin as a possible new severity marker of placental damage. More research is nee…
View article: Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing
Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing Open
There are no validated housekeeping genes in induced pluripotent stem cells (iPSC) and derived endothelial iPSC (iPSC-EC). Thus a comparison of gene expression levels is less reliable, especially during drug treatments. Here, we utilized t…
View article: The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition
The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition Open
(1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to per…
View article: Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing
Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing Open
There are no validated housekeeping genes in induced pluripotent stem cells (iPSC) and derived endothelial iPSC (iPSC-EC). This makes comparison of gene expression levels less reliable especially during drug treatments. Here, we utilized t…
View article: Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage Open
Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with …
View article: Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier Open