Hans Jörg Fehling
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View article: AK2‐Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis
AK2‐Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis Open
Reticular dysgenesis (RD) is a rare genetic disorder caused by mutations in the adenylate kinase 2 ( AK2 ) gene. It is characterized by a T − B − severe combined immunodeficiency, agranulocytosis, and sensorineural deafness. We established…
View article: Cross-talk between ILC2 and Gata3 <sup>high</sup> T <sub>regs</sub> locally constrains adaptive type 2 immunity
Cross-talk between ILC2 and Gata3 <sup>high</sup> T <sub>regs</sub> locally constrains adaptive type 2 immunity Open
Regulatory T cells (T regs ) control adaptive immunity and restrain type 2 inflammation in allergic disease. Interleukin-33 promotes the expansion of tissue-resident T regs and group 2 innate lymphoid cells (ILC2s); however, how T regs loc…
View article: T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation Open
Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucle…
View article: Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation
Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation Open
Background Allergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches. Immunoproteasome inhibition impairs T helper cell func…
View article: BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function
BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function Open
BOB.1/OBF.1 is a lymphocyte‐specific transcriptional co‐activator of octamer‐dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct‐1 and Oct‐2 transcription factors. So far,…
View article: Novel, Non–Gene-Destructive Knock-In Reporter Mice Refute the Concept of Monoallelic <i>Gata3</i> Expression
Novel, Non–Gene-Destructive Knock-In Reporter Mice Refute the Concept of Monoallelic <i>Gata3</i> Expression Open
Accurately tuned expression levels of the transcription factor GATA-3 are crucial at several stages of T cell and innate lymphoid cell development and differentiation. Moreover, several lines of evidence suggest that Gata3 expression might…
View article: IL‐7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival
IL‐7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival Open
The survival of peripheral T cells is dependent on their access to peripheral LNs (pLNs) and stimulation by IL‐7. In pLNs fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) produce IL‐7 suggesting their contribution…
View article: Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death Open
TGF-β–activated kinase 1 (TAK1) is known to play vital roles for innate and adaptive immunity; however, little is known about its potential role in limiting biological responses such as inflammation. In this study, we report that macrophag…
View article: CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis
CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis Open
View article: The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection
The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection Open
T cell development is critically dependent on successful rearrangement of antigen-receptor chains. At the β-selection checkpoint, only cells with a functional rearrangement continue in development. However, how nonselected T cells proceed …
View article: Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts
Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts Open
View article: Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer
Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer Open
View article: The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice Open
Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. Here, we add to emerging evidence that all six H3K4 met…
View article: Dynamic changes in intrathymic ILC populations during murine neonatal development
Dynamic changes in intrathymic ILC populations during murine neonatal development Open
Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is l…
View article: Author response: The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice
Author response: The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice Open
View article: Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation
Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation Open
Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite (HDM)-mediated airway inflammation additionally requires T…
View article: Tumour ischaemia by interferon-γ resembles physiological blood vessel regression
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression Open
View article: The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction
The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction Open
Haematopoietic stem and progenitor cells (HSPCs), which sustain lifelong production of all haematopoietic cell types, are known to be exquisitely sensitive to DNA-damaging events, like γ-irradiatio...
View article: DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization
DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization Open
View article: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus Open
Retinoid-related orphan receptor gamma t (RORγt) is a master transcription factor central to type 17 immunity involving cells such as T helper 17, group 3 innate lymphoid cells or IL-17-producing γδ T cells. Here we show that the intracell…
View article: Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease
Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease Open
Significance Although T cells are the main players in autoimmune CNS inflammation, the role of B cells is being increasingly appreciated. We here investigated possible scenarios of how B cells could participate in the initiation of autoimm…
View article: Identification of a novel lymphoid population in the murine epidermis
Identification of a novel lymphoid population in the murine epidermis Open
T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid po…