Hans Lassmann
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View article: The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion
The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion Open
Rasmussen Encephalitis (RE) is a chronic, unilateral epileptic disorder mostly found in children. Neuropathologically, it is characterized by T lymphocyte infiltration targeting neurons and leading to microglia activation, astrogliosis, an…
View article: Myelin antigen-specific effector CD8<sup>+</sup>T cells induce chronic CNS autoimmunity in a CD4<sup>+</sup>T cell-dependent manner
Myelin antigen-specific effector CD8<sup>+</sup>T cells induce chronic CNS autoimmunity in a CD4<sup>+</sup>T cell-dependent manner Open
Both CD4 + and CD8 + T cells play critical roles in the immunopathogenesis of multiple sclerosis (MS). 1C6 T cell receptor transgenic (TcR-Tg) mice on the nonobese diabetic (NOD) background have a MOG [35-55]- specific, MHC class II-restri…
View article: Subcortical plaques and inflammation reflect cortical and meningeal pathologies in progressive multiple sclerosis
Subcortical plaques and inflammation reflect cortical and meningeal pathologies in progressive multiple sclerosis Open
It remains elusive whether lesions and inflammation in the sub/juxtacortical white matter reflect cortical and/or meningeal pathologies. Elucidating this could have implications for MRI monitoring as sub/juxtacortical lesions are detectabl…
View article: Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization
Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization Open
Microglia are strongly implicated in demyelinating neurodegenerative diseases with increasing evidence for roles in protection and healing, but the mechanisms that control CNS remyelination are poorly understood. Here, we show that microgl…
View article: Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD
Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD Open
The complement pathway is activated in both MOGAD and AQP4+NMOSD, but MAC formation is lower in MOGAD, particularly in those with mild attacks, than in AQP4+NMOSD. These findings may have pathogenetic and therapeutic implications in MOGAD.
View article: The ageing central nervous system in multiple sclerosis: the imaging perspective
The ageing central nervous system in multiple sclerosis: the imaging perspective Open
The interaction between ageing and multiple sclerosis is complex and carries significant implications for patient care. Managing multiple sclerosis effectively requires an understanding of how ageing and multiple sclerosis impact brain str…
View article: Issue Information
Issue Information Open
HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open a…
View article: Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis Open
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentl…
View article: Ineffective control of Epstein–Barr virus infection is seen in MS: What is next?
Ineffective control of Epstein–Barr virus infection is seen in MS: What is next? Open
The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world.1 Migration studies have shown that age at migration has a significant influence on whether the risk of developing…
View article: IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity Open
Background Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. Many immune aspects of the disease are understood through studies in the experimental autoimmune encepha…
View article: The relation between <scp>BTK</scp> expression and iron accumulation of myeloid cells in multiple sclerosis
The relation between <span>BTK</span> expression and iron accumulation of myeloid cells in multiple sclerosis Open
Activation of Bruton's tyrosine kinase (BTK) has been shown to play a crucial role in the proinflammatory response of B cells and myeloid cells upon engagement with B cell, Fc, Toll‐like receptor, and distinct chemokine receptors. Previous…
View article: Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects
Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects Open
Background: Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein not previously described in the human central nervous system (CNS). Objectives: We determined MFAP4 CNS expression and measured cerebrospinal fluid …
View article: Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis
Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis Open
Background: Paramagnetic rim lesions (PRLs) are an imaging biomarker in multiple sclerosis (MS), associated with a more severe disease. Objectives: To determine quantitative magnetic resonance imaging (MRI) metrics of PRLs, lesions with di…
View article: Microfibrillar-associated Protein 4 as Potential Marker of Acute Relapse in Inflammatory Demyelinating Diseases of the Central Nervous System: Pathological and Clinical Aspects
Microfibrillar-associated Protein 4 as Potential Marker of Acute Relapse in Inflammatory Demyelinating Diseases of the Central Nervous System: Pathological and Clinical Aspects Open
Background and Objectives: Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein not previously described in the central nervous system (CNS). We aimed to determine MFAP4 CNS expression and measure cerebrospinal fl…
View article: Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury
Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury Open
This study provides immunologic, neurobiological, and neuropathologic proof-of-principle for an antibody-mediated autoimmunity response emerging approximately 3 weeks after SCI in a patient subpopulation with a high demand of neuropathic p…
View article: Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events
Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events Open
Blinatumomab, a CD19/CD3-bispecific T-cell engager (BiTE) immuno-oncology therapy for the treatment of B-cell malignancies, is associated with neurologic adverse events in a subgroup of patients. Here, we provide evidence for a two-step pr…
View article: Supplementary Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events
Supplementary Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events Open
Table S1. Designs, primary results, and incidences of neurologic adverse events of the five clinical studies with blinatumomab of which data was used in present analysis; Table S2: Multivariate analyses of blinatumomab-treated patients wit…
View article: Supplementary Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events
Supplementary Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events Open
Table S1. Designs, primary results, and incidences of neurologic adverse events of the five clinical studies with blinatumomab of which data was used in present analysis; Table S2: Multivariate analyses of blinatumomab-treated patients wit…
View article: Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events
Data from Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events Open
Blinatumomab, a CD19/CD3-bispecific T-cell engager (BiTE) immuno-oncology therapy for the treatment of B-cell malignancies, is associated with neurologic adverse events in a subgroup of patients. Here, we provide evidence for a two-step pr…
View article: Long‐term clinical, imaging and cognitive outcomes association with <scp>MS</scp> immunopathology
Long‐term clinical, imaging and cognitive outcomes association with <span>MS</span> immunopathology Open
Objective In this observational study on a cohort of biopsy‐proven central nervous system demyelinating disease consistent with MS, we examined the relationship between early‐active demyelinating lesion immunopattern (IP) with subsequent c…
View article: Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis Open
Aims Axonal injury in multiple sclerosis (MS) and experimental models is most frequently detected in acutely demyelinating lesions. We recently reported a compensatory neuronal response, where mitochondria move to the acutely demyelinated …
View article: Peripheral Hemolysis in Relation to Iron Rim Presence and Brain Volume in Multiple Sclerosis
Peripheral Hemolysis in Relation to Iron Rim Presence and Brain Volume in Multiple Sclerosis Open
Background: Iron rim lesions (IRLs) represent chronic lesion activity and are associated with a more severe disease course in multiple sclerosis (MS). How the iron rims around the lesions arise in patients with MS (pwMS), and whether perip…
View article: The contribution of neuropathology to multiple sclerosis research
The contribution of neuropathology to multiple sclerosis research Open
Background and purpose Neuropathology plays a major role in deciphering disease mechanisms in multiple sclerosis (MS). This review article describes recent advances in neuropathological research related to inflammatory demyelinating diseas…
View article: Tissue donations for multiple sclerosis research: current state and suggestions for improvement
Tissue donations for multiple sclerosis research: current state and suggestions for improvement Open
Although major progress in multiple sclerosis research has been made during the last decades, key questions related to the cause and the mechanisms of brain and spinal cord pathology remain unresolved. These cover a broad range of topics, …
View article: Neuroinflammation: 2022 update
Neuroinflammation: 2022 update Open
Besides important progress in the understanding of the pathological substrate of COVID-19-associated brain disease, major insights into mechanisms of neurodegeneration in human disease have been provided in neuropathological studies publis…
View article: Iron Rims in Patients With Multiple Sclerosis as Neurodegenerative Marker? A 7-Tesla Magnetic Resonance Study
Iron Rims in Patients With Multiple Sclerosis as Neurodegenerative Marker? A 7-Tesla Magnetic Resonance Study Open
Introduction: Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system, characterized by inflammatory-driven demyelination. Symptoms in MS manifest as both physical and neuropsychological defic…