Hanwen Huang
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View article: Current perspectives and global trends of nanotechnology in advanced breast cancer: a bibliometric and visualized analysis
Current perspectives and global trends of nanotechnology in advanced breast cancer: a bibliometric and visualized analysis Open
Despite advancements in diagnosis and treatment methods for advanced breast cancer (ABC), a more extensive breast cancer (BC) stage with heterogeneity in clinical features, its clinical management remains a substantial challenge. Furthermo…
View article: Schrödinger bridge based deep conditional generative learning
Schrödinger bridge based deep conditional generative learning Open
View article: PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade
PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade Open
Taken together, these findings highlight the critical role of the PRMT5-regulated Wnt/β-catenin pathway in RGC senescence and neurodegeneration. Targeting this pathway represents a promising therapeutic strategy for glaucoma.
View article: Statistical Inference in Classification of High-dimensional Gaussian Mixture
Statistical Inference in Classification of High-dimensional Gaussian Mixture Open
We consider the classification problem of a high-dimensional mixture of two Gaussians with general covariance matrices. Using the replica method from statistical physics, we investigate the asymptotic behavior of a general class of regular…
View article: Schrödinger bridge based deep conditional generative learning
Schrödinger bridge based deep conditional generative learning Open
Conditional generative models represent a significant advancement in the field of machine learning, allowing for the controlled synthesis of data by incorporating additional information into the generation process. In this work we introduc…
View article: One-step data-driven generative model via Schrödinger Bridge
One-step data-driven generative model via Schrödinger Bridge Open
Generating samples from a probability distribution is a fundamental task in machine learning and statistics. This article proposes a novel scheme for sampling from a distribution for which the probability density $μ({\bf x})$ for ${\bf x}\…
View article: The Production of Soluble Regenerated Silk Fibroin Powder with High Molecular Weight and Silk Protein-Based Materials
The Production of Soluble Regenerated Silk Fibroin Powder with High Molecular Weight and Silk Protein-Based Materials Open
View article: Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes Open
Introduction While cystic fibrosis (CF) lung disease is characterized by persistent inflammation and infections and chronic inflammatory diseases are often accompanied by autoimmunity, autoimmune reactivity in CF has not been studied in de…
View article: EPS4.08 Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection and cystic fibrosis-related diabetes
EPS4.08 Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection and cystic fibrosis-related diabetes Open
View article: Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear how prostate cancer cells sustain dysregulated fatty acid …
View article: Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Table S1. ChIP-qPCR primer sequences 5 kb upstream of ACSL4 Table S2. Primer sequences used for shRNAs, RT-PCR and ACSL4 primers 9 Figure S1. ACSLs expression levels in prostate cancer cell lines. Figure S2, related to Figure 3. Identifica…
View article: Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Table S1. ChIP-qPCR primer sequences 5 kb upstream of ACSL4 Table S2. Primer sequences used for shRNAs, RT-PCR and ACSL4 primers 9 Figure S1. ACSLs expression levels in prostate cancer cell lines. Figure S2, related to Figure 3. Identifica…
View article: Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear how prostate cancer cells sustain dysregulated fatty acid …
View article: Quantitative mass spectrometric analysis of hepatocellular carcinoma biomarker alpha-fetoprotein
Quantitative mass spectrometric analysis of hepatocellular carcinoma biomarker alpha-fetoprotein Open
A quantitative analytical method using mass spectrometry and enzymatic reactions has been developed for the detection of alpha-fetoprotein in hepatocellular carcinoma.
View article: Impact of Zinc, Vitamins C and D on Disease Prognosis among Patients with COVID-19 in Bangladesh: A Cross-Sectional Study
Impact of Zinc, Vitamins C and D on Disease Prognosis among Patients with COVID-19 in Bangladesh: A Cross-Sectional Study Open
Vitamin C, (ascorbic acid), vitamin D (cholecalciferol) and zinc (zinc sulfate monohydrate) supplements are important in immunity against coronavirus disease-2019 (COVID-19). However, a limited number of studies have been conducted on the …
View article: Phase transition and higher order analysis of $L_q$ regularization under dependence
Phase transition and higher order analysis of $L_q$ regularization under dependence Open
We study the problem of estimating a $k$-sparse signal ${\mbox{$β$}}_0\in{\bf R}^p$ from a set of noisy observations ${\bf y}\in{\bf R}^n$ under the model ${\bf y}={\bf X}{\mbox{$β$}}+{\bf w}$, where ${\bf X}\in{\bf R}^{n\times p}$ is the …
View article: The development and validation of a m6A-lncRNAs based prognostic model for overall survival in lung squamous cell carcinoma
The development and validation of a m6A-lncRNAs based prognostic model for overall survival in lung squamous cell carcinoma Open
The m6A-lncRNA risk-score model is an independent prognostic factor for OS in LUSC patients. However, the risk-score model need to be further tested clinically.
View article: Microarray and Bioinformatics Analysis of Differential Gene and lncRNA Expression during Erythropoietin Treatment of Acute Spinal Cord Injury in Rats
Microarray and Bioinformatics Analysis of Differential Gene and lncRNA Expression during Erythropoietin Treatment of Acute Spinal Cord Injury in Rats Open
Purpose. We performed a genome-wide analysis of long noncoding RNA (lncRNA) expression to identify novel targets for the further study of recombinant human erythropoietin (rhEPO) treatment of acute spinal cord injury (SCI) in rats. Methods…
View article: LASSO risk and phase transition under dependence
LASSO risk and phase transition under dependence Open
We consider the problem of recovering a k-sparse signal β0∈Rp from noisy observations y=Xβ0+w∈Rn. One of the most popular approaches is the l1-regularized least squares, also known as LASSO. We analyze the mean square error of LASSO in the…
View article: Increased expression of HIST1H1D in esophageal carcinoma predicts poor survival: A study base on TCGA database
Increased expression of HIST1H1D in esophageal carcinoma predicts poor survival: A study base on TCGA database Open
Background: Expression level of HIST1H1D, a linker histone H1 gene, was reported to be associated with poor prognosis in some malignant tumors. Online database showed that HIST1H1D was increased in esophageal carcinoma. The current study a…
View article: LASSO risk and phase transition under dependence
LASSO risk and phase transition under dependence Open
We consider the problem of recovering a $k$-sparse signal ${\mbox{$β$}}_0\in\mathbb{R}^p$ from noisy observations $\bf y={\bf X}\mbox{$β$}_0+{\bf w}\in\mathbb{R}^n$. One of the most popular approaches is the $l_1$-regularized least squares…
View article: Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells
Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells Open
Chordoma is a rare low‑grade tumor of the axial skeleton. Over previous decades, a range of targeted drugs have been used for treating chordoma, with more specific and effective therapies under investigation. Transmembrane Emp24 protein tr…
View article: Chemoradiotherapy and Increased Prescription Dose in Esophageal Squamous Cell Cancer: A Retrospective Study
Chemoradiotherapy and Increased Prescription Dose in Esophageal Squamous Cell Cancer: A Retrospective Study Open
To analyze the outcomes and adverse events of patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiation with modified radiotherapy volume and increased radiation dose. This was a retrospective analysis …
View article: Nonparametric Bayesian Variable Selection With Applications to Multiple Quantitative Trait Loci Mapping With Epistasis and Gene–Environment Interaction
Nonparametric Bayesian Variable Selection With Applications to Multiple Quantitative Trait Loci Mapping With Epistasis and Gene–Environment Interaction Open
The joint action of multiple genes is an important source of variation for complex traits and human diseases. However, mapping genes with epistatic effects and gene–environment interactions is a difficult problem because of relatively smal…
View article: Gaussian Process Based Bayesian Semiparametric Quantitative Trait Loci Interval Mapping
Gaussian Process Based Bayesian Semiparametric Quantitative Trait Loci Interval Mapping Open
In linkage analysis, it is often necessary to include covariates such as age or weight to increase power or avoid spurious false positive findings. However, if a covariate term in the model is specified incorrectly (e.g., a quadratic term …
View article: Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear how prostate cancer cells sustain dysregulated fatty acid …
View article: Asymptotic risk and phase transition of $l_{1}$-penalized robust estimator
Asymptotic risk and phase transition of $l_{1}$-penalized robust estimator Open
Mean square error (MSE) of the estimator can be used to evaluate the performance of a regression model. In this paper, we derive the asymptotic MSE of $l_{1}$-penalized robust estimators in the limit of both sample size $n$ and dimension $…
View article: Design of face recognition system based on CNN
Design of face recognition system based on CNN Open
This paper studies and implements a face recognition system based on convolutional neural network. The system firstly uses AdaBoost algorithm to detect the face, that is to get the position and size of the face accurately in the image, the…
View article: Relationship between food composition and its cold/hot properties: A statistical study
Relationship between food composition and its cold/hot properties: A statistical study Open
Food cold/hot properties are one of the basic principles of traditional Chinese medicine (TCM) and have been used as a basis to make healthy food choices in oriental countries for thousands of years. It is of great interest to know how the…
View article: HEALTHY LIFE EXPECTANCY OF OLDER HISPANICS: THE INFLUENCE OF NEIGHBORHOOD CHARACTERISTICS
HEALTHY LIFE EXPECTANCY OF OLDER HISPANICS: THE INFLUENCE OF NEIGHBORHOOD CHARACTERISTICS Open
Research consistently shows a survival advantage among Hispanics, despite a worse health profile. The goal of this study was to calculate disability free life expectancy for older Hispanics in the United States, and to explore any differen…