Hanwen Li
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View article: Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression
Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression Open
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Tubular abnormalities may precede glomerular pathology and indicate functional progression of DKD. Here, we find glucagon injection exacerbates lipid accumulat…
View article: Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy
Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy Open
Background Calcified lumbar disc herniation (CLDH) is one specific type of lumbar disc herniation (LDH). Currently, there are no uniform classification standards for different calcification degrees of herniated lumbar disc tissue. Percutan…
View article: PZT optical memristors
PZT optical memristors Open
Optical memristors represent a monumental leap in the fusion of photonics and electronics for neuromorphic computing and artificial intelligence. Here, we reveal the first lead zirconate titanate (PZT) optical memristor, working with a par…
View article: N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification
N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification Open
Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1‐related circRNA, is stably downregulated under abnormal stress. In vitro, circSMAD4 knoc…
View article: Soil-Plant Coupling Mediates Stable Isotope Responses to Moisture Gradients in an Extreme Arid Marsh Ecosystem
Soil-Plant Coupling Mediates Stable Isotope Responses to Moisture Gradients in an Extreme Arid Marsh Ecosystem Open
View article: Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum Open
[This corrects the article DOI: 10.7150/ijbs.46153.].
View article: Approaches of Malaysian Education System To Address Teachers' Shortage Issue
Approaches of Malaysian Education System To Address Teachers' Shortage Issue Open
The dearth of trained instructors in Malaysia is significantly affecting both classroom teaching and academic achievement of the students. This article tries to evaluate the numerous strategies employed by Malaysia's government and educati…
View article: Genomic composition and pathomechanisms of porcine circoviruses: A review
Genomic composition and pathomechanisms of porcine circoviruses: A review Open
Porcine circovirus (PCV) belongs to the genus Circovirus within the family Circoviridae; it has the smallest genome and a complicated classification system comprising PCV1, PCV2, PCV3, and PCV4. Most types of these viruses ca…
View article: Multi-omics insights implicate the remodeling of the intestinal structure and microbiome in aging
Multi-omics insights implicate the remodeling of the intestinal structure and microbiome in aging Open
Background Aging can impair the ability of elderly individuals to fight infections and trigger persistent systemic inflammation, a condition known as inflammaging. However, the mechanisms underlying the development of inflammaging remain u…
View article: PZT Optical Memristors
PZT Optical Memristors Open
Optical memristors represent a monumental leap in the fusion of photonics and electronics, heralding a new era of applications from neuromorphic computing to artificial intelligence. However, current technologies are hindered by complex fa…
View article: [Mechanism of tetramethylpyrazine attenuates inflammatory injury in endothelial cells by activating the SIRT1 signaling pathway].
[Mechanism of tetramethylpyrazine attenuates inflammatory injury in endothelial cells by activating the SIRT1 signaling pathway]. Open
TMP may attenuate TNF-α-induced inflammatory injury in HCAEC, which is associated with the inhibition of pyroptosis and activation of the SIRT1 signaling pathway.
View article: Evidence for ~12-h ultradian gene programs in humans
Evidence for ~12-h ultradian gene programs in humans Open
View article: Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7
Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7 Open
N6‐methyladenosine (m 6 A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role in oral mucosal immunity remains ambiguous. Periodontitis is a special but prevalent infectious di…
View article: Percutaneous kyphoplasty with or without posterior pedicle screw fixation for the management of severe osteoporotic vertebral compression fractures with nonunion
Percutaneous kyphoplasty with or without posterior pedicle screw fixation for the management of severe osteoporotic vertebral compression fractures with nonunion Open
Objective To assess the radiographic outcomes, clinical outcomes and complications of percutaneous kyphoplasty (PKP) with and without posterior pedicle screw fixation (PPSF) in the treatment of severe osteoporotic vertebral compression fra…
View article: Proteome characterization of liver–kidney comorbidity after microbial sepsis
Proteome characterization of liver–kidney comorbidity after microbial sepsis Open
Sepsis is a life‐threatening condition that occurs when the body responds to an infection but subsequently triggers widespread inflammation and impaired blood flow. These pathologic responses can rapidly cause multiple organ dysfunction or…
View article: N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis
N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis Open
Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their i…
View article: Magnesium promotes vascularization and osseointegration in diabetic states
Magnesium promotes vascularization and osseointegration in diabetic states Open
View article: Comparison of percutaneous endoscopic interlaminar discectomy and conventional open lumbar discectomy for L4/5 and L5/S1 double-segmental lumbar disk herniation
Comparison of percutaneous endoscopic interlaminar discectomy and conventional open lumbar discectomy for L4/5 and L5/S1 double-segmental lumbar disk herniation Open
Objective Although spinal endoscopic techniques have shown great advantages in the treatment of single-segment lumbar disk herniation (LDH), the therapeutic advantages for double-segment LDH are controversial. To compare the outcomes of pe…
View article: Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration Open
Background Cell transplantation has been demonstrated as a promising approach in tissue regeneration. However, the reactive oxygen species (ROS) accumulation and inflammation condition establish a harsh microenvironment in degenerated tiss…
View article: Calponin 2 regulates ketogenesis to mitigate acute kidney injury
Calponin 2 regulates ketogenesis to mitigate acute kidney injury Open
Calponin 2 (CNN2) is a prominent actin stabilizer. It regulates fatty acid oxidation (FAO) by interacting with estrogen receptor 2 (ESR2) to determine kidney fibrosis. However, whether CNN2 is actively involved in acute kidney injury (AKI)…
View article: Comparison of <scp>Anterior Cervical Discectomy Fusion</scp> Combined with <scp>Lateral Mass Screw</scp> and with <scp>Cervical Pedicle Screw</scp> Fixation Surgery under O‐Arm Navigation for Single‐Stage Management of Severe Lower Cervical Fracture Dislocation
Comparison of <span>Anterior Cervical Discectomy Fusion</span> Combined with <span>Lateral Mass Screw</span> and with <span>Cervical Pedicle Screw</span> Fixation Surgery under O‐Arm Navigation for Single‐Stage Management of Severe Lower Cervical Fracture Dislocation Open
Objective The incidence of severe lower cervical fractures and dislocations due to trauma has increased significantly, and the optimal treatment remains controversial. This study compares the safety and efficacy of anterior cervical discec…
View article: Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration
Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration Open
High levels of reactive oxygen species (ROS) lead to progressive deterioration of mitochondrial function, resulting in tissue degeneration. In this study, ROS accumulation induced nucleus pulposus cells (NPCs) senescence is observed in deg…
View article: Vanillin-based functionalization strategy to construct multifunctional microspheres for treating inflammation and regenerating intervertebral disc
Vanillin-based functionalization strategy to construct multifunctional microspheres for treating inflammation and regenerating intervertebral disc Open
Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain. Although local delivery strategies using biomaterial carriers have shown potential for IVDD treatment, it remains challenging for intervention against mult…
View article: Comparison of unilateral and bilateral percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures associated with scoliosis
Comparison of unilateral and bilateral percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures associated with scoliosis Open
To assess the clinical and radiographic effectiveness of unilateral and bilateral percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCF) associated with scoliosis, 52 patients with OVCF assoc…
View article: Evidence for conservation of primordial ∼12-hour ultradian gene programs in humans under free-living conditions
Evidence for conservation of primordial ∼12-hour ultradian gene programs in humans under free-living conditions Open
While circadian rhythms are entrained to the once daily light-dark cycle of the sun, many marine organisms exhibit ∼12h ultradian rhythms corresponding to the twice daily movement of the tides. Although human ancestors emerged from circati…
View article: Alpha-ketoglutarate promotes alveolar bone regeneration by modulating M2 macrophage polarization
Alpha-ketoglutarate promotes alveolar bone regeneration by modulating M2 macrophage polarization Open
View article: 11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling
11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that transform cortisone to cortisol, which activates the endogenous glucocorticoid function. 11β-HSD1 has been observed to regulate skeletal metabolism, specifically withi…
View article: The comparison of percutaneous kyphoplasty and vertebroplasty for the management of stage III Kummell disease without neurological symptoms
The comparison of percutaneous kyphoplasty and vertebroplasty for the management of stage III Kummell disease without neurological symptoms Open
View article: Comparison of percutaneous endoscopic interlaminar discectomy and conventional discectomy for double- segmental lumbar disc herniation: a retrospective non- randomized study
Comparison of percutaneous endoscopic interlaminar discectomy and conventional discectomy for double- segmental lumbar disc herniation: a retrospective non- randomized study Open
Objective: The objective of this study was to compare the outcomes of percutaneous endoscopic interlaminar discectomy (PEID) with the conventional lumbar discectomy (CLD) for treatment of double-segmental lumbar disc herniation (LDH).Metho…
View article: Comparison of unilateral and bilateral percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures with scoliosis
Comparison of unilateral and bilateral percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures with scoliosis Open
Objective: To assess the clinical effectiveness and radiographic results of unilateral and bilateral percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCF) associated with scoliosis. Methods …