Hanxi Yi
YOU?
Author Swipe
View article: Evaluating tigecycline dosing for hospital-acquired pneumonia patients: insights from physiologically-based pharmacokinetic modeling of lung exposure
Evaluating tigecycline dosing for hospital-acquired pneumonia patients: insights from physiologically-based pharmacokinetic modeling of lung exposure Open
Tigecycline is increasingly used off-label for hospital-acquired pneumonia (HAP), though its efficacy and optimal dosing remain uncertain. Lung exposure to tigecycline may be affected by pulmonary pH changes induced by bacterial infections…
View article: Metabolic reprogramming in cancer and senescence
Metabolic reprogramming in cancer and senescence Open
The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being the aging of the global population. Statistical data show that cancer incidence and mortality rates show a clear upward trend with age…
View article: Physiologically based pharmacokinetic modelling of cefoperazone in paediatrics
Physiologically based pharmacokinetic modelling of cefoperazone in paediatrics Open
Aims Cefoperazone is commonly used off‐label in the treatment of bacterial meningitis and sepsis in children, and the pharmacokinetic (PK) data are limited in this vulnerable population. The goal of this study was to develop a physiologica…
View article: Simulated drug disposition in critically ill patients to evaluate effective PK/PD targets for combating <i>Pseudomonas aeruginosa</i> resistance to meropenem
Simulated drug disposition in critically ill patients to evaluate effective PK/PD targets for combating <i>Pseudomonas aeruginosa</i> resistance to meropenem Open
Bacterial infections, including those caused by Pseudomonas aeruginosa , often lead to sepsis, necessitating effective antibiotic treatment like carbapenems. The key pharmacokinetic/pharmacodynamic (PK/PD) index correlated to carbapenem ef…
View article: Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer
Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer Open
Our study suggests that targeting TFAP2A may provide a novel and effective strategy for cancer treatment.
View article: A novel method to estimate the absorption rate constant for two-compartment model fitted drugs without intravenous pharmacokinetic data
A novel method to estimate the absorption rate constant for two-compartment model fitted drugs without intravenous pharmacokinetic data Open
The in vivo performances of most drugs after extravascular administration are fitted well with the two-compartment pharmacokinetic (PK) model, but the estimation of absorption rate constant (k a ) for these drugs becomes difficult during u…
View article: Combinatorial Polydopamine-Liposome Nanoformulation as an Effective Anti-Breast Cancer Therapy
Combinatorial Polydopamine-Liposome Nanoformulation as an Effective Anti-Breast Cancer Therapy Open
PDA@Lipo/DOX/ICG is a multifunctional nanoplatform based on PDA-coated liposomes for accurate and efficient combinatorial cancer therapy of chemotherapy and laser-induced PDT/PTT.
View article: Identification of CPT2 as a prognostic biomarker by integrating the metabolism-associated gene signature in colorectal cancer
Identification of CPT2 as a prognostic biomarker by integrating the metabolism-associated gene signature in colorectal cancer Open
Background The incidence of colorectal cancer (CRC) is considered to be the third-highest malignant tumor among all carcinomas. The alterations in cellular bioenergetics (metabolic reprogramming) are associated with several malignant pheno…
View article: Facial Emotion Recognition Using a Novel Fusion of Convolutional Neural Network and Local Binary Pattern in Crime Investigation
Facial Emotion Recognition Using a Novel Fusion of Convolutional Neural Network and Local Binary Pattern in Crime Investigation Open
The exploration of facial emotion recognition aims to analyze psychological characteristics of juveniles involved in crimes and promote the application of deep learning to psychological feature extraction. First, the relationship between f…
View article: A Literature Review on High-Performance Photocatalysts for Sustainable Cancer Therapy
A Literature Review on High-Performance Photocatalysts for Sustainable Cancer Therapy Open
Since cancer is a serious threat to public health worldwide, the development of novel methods and materials for treating cancer rapidly and thoroughly is of great significance. This review summarizes the mechanism and application of photoc…
View article: Improvement of Resveratrol Solubility by Complexation with Lactose Using Organic Solvent Spray Drying Technique
Improvement of Resveratrol Solubility by Complexation with Lactose Using Organic Solvent Spray Drying Technique Open
The purpose of this experiment is to change the crystallization state of resveratrol and improve its solubility and dissolution in water by spray drying technology, so as to improve the feasibility of resveratrol in clinical application. T…
View article: Evaluation of a Modified Flow-Through Method for Predictive Dissolution and In Vitro/In Vivo Correlations of Immediate Release and Extended Release Formulations
Evaluation of a Modified Flow-Through Method for Predictive Dissolution and In Vitro/In Vivo Correlations of Immediate Release and Extended Release Formulations Open
The present study evaluated the ability of a modified flow-through method for predicting in vivo performance of immediate release (IR) and extended release (ER) formulations. In vitro dissolution of two model drugs, paracetamol IR tablets …