Hong Zhou
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View article: Molecular mechanism and clinical significance of Notch3 negative regulation of BRD4 on the growth and survival of esophageal squamous cell carcinoma
Molecular mechanism and clinical significance of Notch3 negative regulation of BRD4 on the growth and survival of esophageal squamous cell carcinoma Open
Objective The aim of this study was to investigate the expression of bromodomain-containing protein 4 (BRD4) and Notch receptor protein 3 (Notch3) in esophageal squamous cell carcinoma (ESCC) and the effect of their interaction on the grow…
View article: Frontal cortical gyrification mediates the association between hippocampal subfield microstructure and cognitive function in Parkinson's disease: A NODDI study highlighting olfactory dysfunction
Frontal cortical gyrification mediates the association between hippocampal subfield microstructure and cognitive function in Parkinson's disease: A NODDI study highlighting olfactory dysfunction Open
View article: GPR65 is a novel immune biomarker and regulates the immune microenvironment in lung adenocarcinoma
GPR65 is a novel immune biomarker and regulates the immune microenvironment in lung adenocarcinoma Open
Background The tumor microenvironment (TME) plays a crucial role in the progression of lung adenocarcinoma (LUAD), and it may serve as the best prognostic predictor of LUAD. GPR65 is an extracellular pH-sensing G protein-coupled receptor a…
View article: A Survey of 3D Reconstruction with Event Cameras
A Survey of 3D Reconstruction with Event Cameras Open
Event cameras are rapidly emerging as powerful vision sensors for 3D reconstruction, uniquely capable of asynchronously capturing per-pixel brightness changes. Compared to traditional frame-based cameras, event cameras produce sparse yet t…
View article: Up-regulation of thrombospondin-1 inhibits the progression of gallbladder cancer
Up-regulation of thrombospondin-1 inhibits the progression of gallbladder cancer Open
View article: A Survey on Event-driven 3D Reconstruction: Development under Different Categories
A Survey on Event-driven 3D Reconstruction: Development under Different Categories Open
Event cameras have gained increasing attention for 3D reconstruction due to their high temporal resolution, low latency, and high dynamic range. They capture per-pixel brightness changes asynchronously, allowing accurate reconstruction und…
View article: A Survey on Event-driven 3D Reconstruction: Development under Different Categories
A Survey on Event-driven 3D Reconstruction: Development under Different Categories Open
Event cameras have gained increasing attention for 3D reconstruction due to their high temporal resolution, low latency, and high dynamic range. They capture per-pixel brightness changes asynchronously, allowing accurate reconstruction und…
View article: Constructing a Mixed-Frequency Financial Stress Index for China Using a Novel Dual-Time-Varying-Weights Ciss and Analyzing its Macroeconomic Effects
Constructing a Mixed-Frequency Financial Stress Index for China Using a Novel Dual-Time-Varying-Weights Ciss and Analyzing its Macroeconomic Effects Open
View article: Emodin-based Regulation and Control of Serum Complement C5a, Oxidative Stress, and Inflammatory Responses in Rats with Urosepsis via AMPK/SIRT1
Emodin-based Regulation and Control of Serum Complement C5a, Oxidative Stress, and Inflammatory Responses in Rats with Urosepsis via AMPK/SIRT1 Open
Emodin, derived from Rheum officinale and aloe, is known for its diverse benefits such as anti-inflammatory, antioxidant, and antibacterial properties. Currently, the impact of emodin on urosepsis is unclear. This study aims to investigate…
View article: Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity
Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity Open
Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Recent findings suggest that disrupting skeletal GC signaling prevents bone loss and alleviates metabolic disorders in high-fat diet (HFD)-fed obese mice, under…
View article: Endogenous glucocorticoids during skeletal ageing
Endogenous glucocorticoids during skeletal ageing Open
Stress hormones, namely glucocorticoids, have diverse actions throughout the body in regulating development, tissue metabolism, inflammation, circadian rhythms, and skeletal homeostasis. While endogenous glucocorticoid levels are important…
View article: Diagnosis of Two Meningitis Cases Caused by Rickettsia Felis in China, with Metagenomic Next-Generation Sequencing: A Case Report
Diagnosis of Two Meningitis Cases Caused by Rickettsia Felis in China, with Metagenomic Next-Generation Sequencing: A Case Report Open
mNGS of cerebrospinal fluid can be used as a fast and effective method to identify intracranial R. felis infections.
View article: Case Report: Successful Treatment of Recurrent Candida Albicans Meningitis with Kimura’s Disease Using Amphotericin B Colloidal Dispersion Combined with Fluconazole
Case Report: Successful Treatment of Recurrent Candida Albicans Meningitis with Kimura’s Disease Using Amphotericin B Colloidal Dispersion Combined with Fluconazole Open
Candida meningitis can occur in the context of Kimura disease. In patients with mild disease, the possibility of recurrence exists with fluconazole treatment alone, and the efficacy of amphotericin B colloidal dispersion combined wi…
View article: Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis
Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis Open
View article: Molecular characterization and 3D Modeling of p62 in Grass Carp (Ctenopharyngodon Idella)
Molecular characterization and 3D Modeling of p62 in Grass Carp (Ctenopharyngodon Idella) Open
P62 is a ubiquitin-binding protein that plays a key role in biological pathways including autophagy and protein degradation. In this study, we analyzed the protein sequence of grass carp p62 (gcp62) and its 3D structure was predicated. The…
View article: High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma
High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma Open
View article: PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes Open
View article: Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects Open
Fucosylation is a common glycan terminal modification, which has been reported to be inhibited by 2-fluorofucose (2FF) both in vivo and in vitro . The present study aimed to investigate the effect of 2FF on acetaminophen (APAP)-induced acu…
View article: MicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy
MicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy Open
We study whether microRNA miR-30a inhibits the autophagy through transforming growth factor (TGF)-β/Smad4 to generate cisplatin (DDP) resistance in ovarian cancer cells. The expression of miR-30a, Smad4, and TGF-β was detected in the serum…
View article: MECHANISMS IN ENDOCRINOLOGY: Local and systemic effects of glucocorticoids on metabolism: new lessons from animal models
MECHANISMS IN ENDOCRINOLOGY: Local and systemic effects of glucocorticoids on metabolism: new lessons from animal models Open
Glucocorticoids regulate a remarkable variety of essential functions, including development, immunomodulation, maintenance of circadian rhythm and the response to stress. Glucocorticoids acutely increase energy availability; this is accomp…
View article: Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity
Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity Open
View article: Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway
Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway Open
Purpose: Angiogenesis post-ischemia plays an essential role in preventing ischemic damage to tissue by improving the blood recovery. Determining the regulatory mechanism of ischemic angiogenesis, therefore, could provide effective therapeu…
View article: Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice
Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice Open
Skeletal glucocorticoid signalling is critical for the development of leptin resistance, obesity and insulin resistance during aging. These findings underscore the skeleton's importance in the regulation of body weight and implicate osteob…
View article: Arthritis and the role of endogenous glucocorticoids
Arthritis and the role of endogenous glucocorticoids Open
Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic, painful, and disabling conditions. Although both diseases differ in etiology, they manifest in progressive joint destruction characterized by patholo…
View article: Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally Open
Background . Hyper-free fatty acidemia (HFFA) impairs cardiac capillaries, as well as type 2 diabetes mellitus (T2DM). Perilipin 5 (Plin5) maintains metabolic balance of free fatty acids (FFAs) in high oxidative tissues via the states of n…
View article: Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation
Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation Open
View article: Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice
Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice Open
The G protein-coupled receptor class C, group 6, subtype A (GPRC6A) is suggested to have a physiological function in glucose and bone metabolism, although the precise role lacks consensus due to varying findings in different knockout (KO) …
View article: RETRACTED: Plumbagin Ameliorates Collagen-Induced Arthritis by Regulating Treg/Th17 Cell Imbalances and Suppressing Osteoclastogenesis
RETRACTED: Plumbagin Ameliorates Collagen-Induced Arthritis by Regulating Treg/Th17 Cell Imbalances and Suppressing Osteoclastogenesis Open
Objective: Plumbago zeylanica L. (with plumbagin as its active ingredients) has been used for centuries to treat conditions such as joint swelling, fractures, and bacterial infections, suggesting that it possesses anti-inflammatory and imm…
View article: Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression
Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression Open
View article: Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally Open