Explanipedia

Advanced CRISPR Technologies for RNA Imaging in Live Cells Open

Xiaoyu Lv, Zonghong Li, Hongzheng Zheng, T. R. Sun, Wenjing Xie , et al. · 2025

A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells Open

Zhaojia Deng, Rui Sha, Hua Qin, Yingxu Shang, Aijiao Yuan , et al. · 2025

Uptake behaviors of gold nanoparticles (AuNPs), spherical nucleic acids (SNAs) and protein corona nanostructures (PCNs) into cells.

Integrated multi-omics approaches reveal the neurotoxicity of triclocarban in mouse brain Open

Qian Song, Chengchen Hu, Xueying Zhang, Pengweilin Ji, Yansong Li , et al. · 2024

Triclocarban (TCC) is an antimicrobial ingredient that commonly incorporated in many household and personal care products, raising public concerns about its potential health risks. Previous research has showed that TCC could cross the bloo…

Inside Cover: A Sensitive Technique Unravels the Kinetics of Activation and Trans ‐Cleavage of CRISPR‐Cas Systems (Angew. Chem. Int. Ed. 22/2024) Open

Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X. Chris Le · 2024

CRISPR-Cas systems are activated by the formation of a ribonucleoprotein and its binding to the target nucleic acid sequence. Both binding processes are important for the overall performance. In their Communication (e202404069) Hongquan Zh…

Innentitelbild: A Sensitive Technique Unravels the Kinetics of Activation and Trans ‐Cleavage of CRISPR‐Cas Systems (Angew. Chem. 22/2024) Open

Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X. Chris Le · 2024

CRISPR-Cas systems are activated by the formation of a ribonucleoprotein and its binding to the target nucleic acid sequence. Both binding processes are important for the overall performance. In their Communication (e202404069) Hongquan Zh…

A Sensitive Technique Unravels the Kinetics of Activation and Trans ‐Cleavage of CRISPR‐Cas Systems Open

Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X. Chris Le · 2024

Activation of the CRISPR‐Cas13a system requires the formation of a crRNA‐Cas13a ribonucleoprotein (RNP) complex and the binding of an RNA activator to the RNP. These two binding processes play a crucial role in the performance of the CRISP…

Protein-Induced DNA Dumbell Amplification (Pinda) and its Applications to Food Hazards Detection Open

Bo Pang, Michael S. Reid, Wei Jia, Hanyong Peng, L. Bu , et al. · 2024

Optimal Fractionation and Timing of Weekly Cone-Beam CT in Daily Surface-Guided Radiotherapy for Breast Cancer Open

Hanyong Peng, Fang Jin, Huan Yang, Hong Luo, Liam Tan · 2023

Mobility of Titanium Clamps in Radiotherapy Patients After Breast-Conserving Surgery and the Correlation With Breast Size and Position of Titanium Clamps Open

Jie Luo, Hanyong Peng, Hong Luo, Fang Jin · 2021

Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA Open

Wei Feng, Hanyong Peng, Jingyang Xu, Yanming Liu, Kanti Pabbaraju , et al. · 2021

CRISPR-Cas systems integrated with nucleic acid amplification techniques improve both analytical specificity and sensitivity. We describe here issues and solutions for the successful integration of reverse transcription (RT), recombinase p…

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules Open

Wei Feng, Ashley M. Newbigging, Jeffrey Tao, Yiren Cao, Hanyong Peng , et al. · 2021

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) protein systems revolutionize genome engineering and advance analytical chemistry and diagnostic technology.

Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9 Open

Jinjun Wu, Hanyong Peng, Xiufen Lu, Maode Lai, Hongquan Zhang , et al. · 2020

Protein coronae formed with nanoparticles confer several useful properties. However, the non‐specific nature of protein corona formation makes it difficult to deliver specific proteins for therapeutic applications. Herein, we report on the…

Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9 Open

Jinjun Wu, Hanyong Peng, Xiufen Lu, Maode Lai, Hongquan Zhang , et al. · 2020

Protein coronae formed with nanoparticles confer several useful properties. However, the non‐specific nature of protein corona formation makes it difficult to deliver specific proteins for therapeutic applications. Herein, we report on the…

Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology Open

Bo Pang, Jingyang Xu, Yan‐Ming Liu, Hanyong Peng, Wei Feng , et al. · 2020

We have developed a single-tube assay for SARS-CoV-2 in patient samples. This assay combined advantages of reverse transcription (RT) loop-mediated isothermal amplification (LAMP) with clustered regularly interspaced short palindromic repe…

Arsenic speciation analysis: A review with an emphasis on chromatographic separations Open

Michael S. Reid, Karen S. Hoy, Jordan R.M. Schofield, Jagdeesh S. Uppal, Yanwen Lin , et al. · 2019

More than 100 different arsenic species of diverse characteristics are present in the environment and biological systems. The identification and quantification of individual arsenic species are critical to understanding the distribution, e…

Signal Amplification in Living Cells: A Review of microRNA Detection and Imaging Open

Hanyong Peng, Ashley M. Newbigging, Michael S. Reid, Jagdeesh S. Uppal, Jingyang Xu , et al. · 2019

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSignal Amplification in Living Cells: A Review of microRNA Detection and ImagingHanyong PengHanyong PengDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and P…

Quantitative synthesis of protein–DNA conjugates with 1 : 1 stoichiometry Open

Xiaowen Yan, Hongquan Zhang, Zhixin Wang, Hanyong Peng, Jeffrey Tao , et al. · 2018

We describe here a binding-facilitated reaction strategy, enabling quantitative conjugation of DNA to native proteins with a desirable 1 : 1 stoichiometry.

DNAzyme-Mediated Assays for Amplified Detection of Nucleic Acids and Proteins Open

Hanyong Peng, Ashley M. Newbigging, Zhixin Wang, Jeffrey Tao, Wenchan Deng , et al. · 2017

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTDNAzyme-Mediated Assays for Amplified Detection of Nucleic Acids and ProteinsHanyong Peng, Ashley M. Newbigging, Zhixin Wang, Jeffrey Tao, Wenchan Deng, X. Chris Le*, and Hongquan Zhang*View Autho…

Titelbild: Methylated Phenylarsenical Metabolites Discovered in Chicken Liver (Angew. Chem. 24/2017) Open

Hanyong Peng, Bin Hu, Qingqing Liu, Jinhua Li, Xing‐Fang Li , et al. · 2017

Hunderte Millionen Menschen …… weltweit sind Arsen-Belastungen ausgesetzt, und es ist bislang nicht bekannt, wie Phenylarsen-Verbindungen, die als Futtermittelzusätze an Hühner verfüttert werden, metabolisieren. In der Zuschrift auf S. 687…

A microRNA-initiated DNAzyme motor operating in living cells Open

Hanyong Peng, Xing‐Fang Li, Hongquan Zhang, X. Chris Le · 2017

Arsenic Species in Chicken Breast: Temporal Variations of Metabolites, Elimination Kinetics, and Residual Concentrations Open

Qingqing Liu, Hanyong Peng, Xiufen Lu, M.J. Zuidhof, Xing‐Fang Li , et al. · 2016

Liu Q, Peng H, Lu X, Zuidhof MJ, Li XF, Le XC. 2016. Arsenic species in chicken breast: temporal variations of metabolites, elimination kinetics, and residual concentrations. Environ Health Perspect 124:1174-1181; http://dx.doi.org/10.1289…

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