Hanyu Dong
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View article: The effect of Ecological Executive Skills training on emotional problems in children with attention-deficit hyperactivity disorder
The effect of Ecological Executive Skills training on emotional problems in children with attention-deficit hyperactivity disorder Open
Background: Emotional problems represents a prevalent clinical manifestation in pediatric populations with attention-deficit/hyperactivity disorder (ADHD), exacerbating functional impairments and complicating treatment outcomes. While phar…
View article: Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism
Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism Open
Vitamin D (VitD) deficiency (VDD) during prenatal and early brain development may be an environmental risk factor for autism spectrum disorder (ASD). While supplementation with high-dose VitD can improve core ASD symptoms, its mechanism is…
View article: Global developmental delay: comparison of developmental profiles between gene-positive/suspicious positive and gene-negative cases
Global developmental delay: comparison of developmental profiles between gene-positive/suspicious positive and gene-negative cases Open
Background Global developmental delay (GDD) is associated with genetic abnormalities; however, the specific clinical and developmental features that should trigger genetic testing remain unclear. In this study, we explored this issue. Meth…
View article: Clinical Application of Risdiplam in 5q Spinal Muscular Atrophy: A Narrative Review
Clinical Application of Risdiplam in 5q Spinal Muscular Atrophy: A Narrative Review Open
5q spinal muscular atrophy (SMA) is caused by mutations in the survival motor neuron (SMN) gene located on chromosome 5, leading to insufficient SMN protein levels. Risdiplam is an RNA splicing modifier that modifies pre-mRNA splicing of t…
View article: Efficacy of high-dose vs. low-dose vitamin D₃ supplementation in children with chronic tic disorders: a randomized controlled trial
Efficacy of high-dose vs. low-dose vitamin D₃ supplementation in children with chronic tic disorders: a randomized controlled trial Open
High-dose vitamin D₃ supplementation is more effective than low-dose supplementation in reducing tic severity and increasing serum 25(OH)D levels in children with CTDs. These findings suggest that high-dose vitamin D₃ may serve as a valuab…
View article: Prolonged screen time is associated with increased severity of tic symptoms in children with tic disorders
Prolonged screen time is associated with increased severity of tic symptoms in children with tic disorders Open
Background Recent studies have emphasized the association between prolonged screen exposure and neurodevelopmental disorders, though its correlation with tic disorders (TDs) remains ambiguous. We thus conducted this study to investigate th…
View article: pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride
pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride Open
Sphingan WL gum (WL) is an extracellular polysaccharide with a carboxyl group produced by Sphingomonas sp. WG. Recently, we have successfully obtained deacetylated WL (DWL) with good water solubility by alkaline treatment. In this s…
View article: A study of the effects of screen exposure on the neuropsychological development in children with autism spectrum disorders based on ScreenQ
A study of the effects of screen exposure on the neuropsychological development in children with autism spectrum disorders based on ScreenQ Open
Purpose To investigate the relationship between multi-dimensional aspects of screen exposure and autistic symptoms, as well as neuropsychological development in children with ASD. Methods We compared the ScreenQ and Griffiths Development S…
View article: Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis
Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis Open
View article: Relationship Between Resilience, Social Support, Existential Well-Being and Negative Emotions in Cervical Cancer Patients: a Mediation Analysis
Relationship Between Resilience, Social Support, Existential Well-Being and Negative Emotions in Cervical Cancer Patients: a Mediation Analysis Open
Background: The patients of cervical cancer have more negative emotions and lower quality of life. The aim of this study was to explore the relationships between existential well-being (EWB), social support, resilience, negative emo…
View article: Vitamin D and Its Receptors in Cervical Cancer
Vitamin D and Its Receptors in Cervical Cancer Open
Several studies have investigated the relationship between vitamin D (VD) and its receptors (VDR) and the risk of cervical cancer. However, the underlying mechanisms that underpin these associations remain incompletely comprehended. In thi…
View article: The relationship between screen time before bedtime and behaviors of preschoolers with autism spectrum disorder and the mediating effects of sleep
The relationship between screen time before bedtime and behaviors of preschoolers with autism spectrum disorder and the mediating effects of sleep Open
View article: Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion
Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion Open
Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes…
View article: The challenges of screen time in children with typical development and children with developmental disorders during COVID-19 pandemic
The challenges of screen time in children with typical development and children with developmental disorders during COVID-19 pandemic Open
During the COVID-19 pandemic, children's screen exposure time increased, and outdoor activities decreased significantly. This represents a significant challenge, and we should focus our efforts on managing children's screen time and promot…
View article: Risk factors for developmental quotients in ASD children: A cross-sectional study
Risk factors for developmental quotients in ASD children: A cross-sectional study Open
Objective To analyze the risk factors for developmental quotients (DQs) of children with autism spectrum disorder (ASD) and to better understand the effects of screen time on neurodevelopment in children with ASD. Methods We retrospectivel…
View article: Physicochemical and Structural Characterization of Alkali-Treated Biopolymer Sphingan WL Gum from Marine <i>Sphingomonas</i> sp. WG
Physicochemical and Structural Characterization of Alkali-Treated Biopolymer Sphingan WL Gum from Marine <i>Sphingomonas</i> sp. WG Open
Sphingan WL gum (WL), a kind of exopolysaccharide, is produced by Sphingomonas sp. WG, which was screened from sea mud samples of Jiaozhou Bay by our group. The solubility of WL was investigated in this work. First, 1 mg/mL of WL so…
View article: Screening of ADHD symptoms in primary school students and investigation of parental awareness of ADHD and its influencing factors: A cross-sectional study
Screening of ADHD symptoms in primary school students and investigation of parental awareness of ADHD and its influencing factors: A cross-sectional study Open
Objective The present study aimed to compare the differences in positive screening rates of attention deficit hyperactivity disorder (ADHD) symptoms between parents and teachers in the same sample of primary school students. Concurrently, …
View article: Analysis of scores of Symptom Checklist 90 (SCL-90) questionnaire of 182 parents of children with spinal muscular atrophy: a cross-sectional study
Analysis of scores of Symptom Checklist 90 (SCL-90) questionnaire of 182 parents of children with spinal muscular atrophy: a cross-sectional study Open
SMA parents have a higher risk of developing psychiatric symptoms problems compared with the general population. Increasing age and the continuous home-living status of SMA children increase the risk of depression in their parents, and the…
View article: A Probable Way Vitamin D Affects Autism Spectrum Disorder: The Nitric Oxide Signaling Pathway
A Probable Way Vitamin D Affects Autism Spectrum Disorder: The Nitric Oxide Signaling Pathway Open
Vitamin D (VD) deficiency during pregnancy and early brain development is an important environmental risk factor for autism spectrum disorder (ASD). Its specific mechanism of action is still unclear. However, one study on the correlation b…
View article: Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death Open
Glutamine, like glucose, is a major nutrient consumed by cancer cells, yet these cells undergo glutamine starvation in the cores of tumors, forcing them to evolve adaptive metabolic responses. Pharmacologically targeting glutamine metaboli…
View article: Screen Time, Age and Sunshine Duration Rather Than Outdoor Activity Time Are Related to Nutritional Vitamin D Status in Children With ASD
Screen Time, Age and Sunshine Duration Rather Than Outdoor Activity Time Are Related to Nutritional Vitamin D Status in Children With ASD Open
Objective: This study aimed to investigate the possible association among vitamin D, screen time and other factors that might affect the concentration of vitamin D in children with autism spectrum disorder (ASD). Methods: In total, 306 chi…
View article: Non-parental caregivers, low maternal education, gastrointestinal problems and high blood lead level: predictors related to the severity of autism spectrum disorder in Northeast China
Non-parental caregivers, low maternal education, gastrointestinal problems and high blood lead level: predictors related to the severity of autism spectrum disorder in Northeast China Open
View article: Correlation Between Serum Concentrations of Menaquinone-4 and Developmental Quotients in Children With Autism Spectrum Disorder
Correlation Between Serum Concentrations of Menaquinone-4 and Developmental Quotients in Children With Autism Spectrum Disorder Open
Objective: The vitamin K family has a wide range of effects in the body, including the central nervous system. Menaquinone-4 (MK-4), a form of vitamin K2, is converted from phylloquinone (PK), which is the main source of dietary vitamin K …
View article: Screen Time and Autism: Current Situation and Risk Factors for Screen Time Among Pre-school Children With ASD
Screen Time and Autism: Current Situation and Risk Factors for Screen Time Among Pre-school Children With ASD Open
Objective: To investigate the current status of screen time in children with ASD, its correlation with autistic symptoms and developmental quotient (DQ), and the factors affecting screen time. Method: One hundred ninety-three Chinese child…
View article: Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9
Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9 Open
The proinflammatory cytokine tumor necrosis factor-α (TNF-α)-induced degradation of extracellular matrix (ECM), such as type II collagen in chondrocytes, plays an important role in the development of osteoarthritis (OA). Telmisartan, an an…
View article: Correlation Between Screen Time and Autistic Symptoms as Well as Development Quotients in Children With Autism Spectrum Disorder
Correlation Between Screen Time and Autistic Symptoms as Well as Development Quotients in Children With Autism Spectrum Disorder Open
Background: Electronic screen media play an increasingly vital role in children's entertainment; however, excessive screen time may negatively influence child development. The purpose of this study was to investigate the relationship betwe…
View article: Low Maternal Education, Gastrointestinal Problems and High Blood Lead Level: Risk Factors Related to the Severity of Autism Spectrum Disorder in Northeast China
Low Maternal Education, Gastrointestinal Problems and High Blood Lead Level: Risk Factors Related to the Severity of Autism Spectrum Disorder in Northeast China Open
Background: The prevalence of autism spectrum disorder (ASD) has increased rapidly in recent years. Environmental factors may play an important role in the pathogenesis of ASD. These factors may include socioeconomic factors, nutritional f…
View article: Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency
Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency Open
Rational: Tyrosine hydroxylase deficiency (THD) is a rare cause of dopa-responsive dystonia (DRD). Although the symptoms of DRD may be improved by treatment with L-dopa, the low morbidity of THD can lead to its misdiagnosis. Thus, it is im…
View article: The effects of high versus low talker variability and individual aptitude on phonetic training of Mandarin lexical tones
The effects of high versus low talker variability and individual aptitude on phonetic training of Mandarin lexical tones Open
High variability (HV) training has been found to be more effective than low variability (LV) training when learning various non-native phonetic contrasts. However, little research has considered whether this applies to the learning of tone…
View article: Peer Review #1 of "The effects of high versus low talker variability and individual aptitude on phonetic training of Mandarin lexical tones (v0.1)"
Peer Review #1 of "The effects of high versus low talker variability and individual aptitude on phonetic training of Mandarin lexical tones (v0.1)" Open
High variability training has been found to be more effective than low variability training when learning various non-native phonetic contrasts.However, little research has considered whether this applies to the learning of tone contrasts.…