Jun Wu
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View article: CLE14 peptide delays broccoli senescence by regulating chlorophyll metabolism and reactive oxygen species homeostasis
CLE14 peptide delays broccoli senescence by regulating chlorophyll metabolism and reactive oxygen species homeostasis Open
CLE (CLAVATA3/Endosperm surrounding region-related) is a peptide hormone with multiple biological functions in plants. Previous studies have demonstrated that it plays an important role in modulating leaf senescence in Arabidopsis. However…
View article: Gut viral metagenomics identifies viral signatures and their role in depression
Gut viral metagenomics identifies viral signatures and their role in depression Open
Background The gut microbiome has been implicated in the onset and progression of depression. Yet, the role of the gut virome in depression remains unexplored, and a diagnostic model has not been satisfactorily constructed. Methods Herein,…
View article: Prognostic value of left atrial strain in significant aortic valve disease: a systematic review and meta-analysis
Prognostic value of left atrial strain in significant aortic valve disease: a systematic review and meta-analysis Open
Background Previous studies on aortic valve disease have mainly focused on the left ventricle, but increasing evidence suggests that left atrial strain also has prognostic value in significant aortic valve disease. Objective To systematica…
View article: D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis
D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis Open
Renal tubular cells actively participate in fibrosis, leading to end‐stage renal failure. However, the key molecules involved in fibrogenesis remain unclear. Glucuronyl C5‐epimerase ( Hsepi , gene name, Glce ) is a key enzyme that catalyze…
View article: CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for cortical neural stem cell maintenance
CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for cortical neural stem cell maintenance Open
Radial glial cells (RGCs) are the neural stem cells (NSCs) in the developing brain, capable of self-renewing and generating neurons and glia in order. The developmental behaviors of NSCs are determined by extrinsic factors from the NSC nic…
View article: Ultrasound-based deep learning radiomics for enhanced axillary lymph node metastasis assessment: a multicenter study
Ultrasound-based deep learning radiomics for enhanced axillary lymph node metastasis assessment: a multicenter study Open
Background Accurate preoperative assessment of axillary lymph node metastasis (ALNM) in breast cancer is crucial for guiding treatment decisions. This study aimed to develop a deep-learning radiomics model for assessing ALNM and to evaluat…
View article: <i>NOTCH1</i> Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial
<i>NOTCH1</i> Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial Open
PURPOSE Although multiple agents targeting PD-1 have been approved as second-line treatment for esophageal squamous cell carcinoma (ESCC), only a fraction of patients derive long-term survival. Hence, reliable predictive biomarkers are urg…
View article: Predictors of Severity in Hemorrhagic Fever with Renal Syndrome
Predictors of Severity in Hemorrhagic Fever with Renal Syndrome Open
PCT, ALB, PAR, and pleural effusion are risk factors for the severity of HFRS. The constructed nomogram model exhibits good discriminatory power, fit, and clinical practicality, enabling early identification of patients with severe HFRS in…
View article: A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis
A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis Open
Atrial fibrillation (AF) is a common arrhythmia with irregular atrial electrical activity. Circular RNAs (circRNAs) are key regulators in tissue homeostasis, yet their role in AF remains unclear. Here, we investigated the expression and fu…
View article: Exploratory Analysis of Sleep Deprivation Effects on Gene Expression and Regional Brain Metabolism
Exploratory Analysis of Sleep Deprivation Effects on Gene Expression and Regional Brain Metabolism Open
Introduction: Sleep deprivation affects cognitive performance and immune function, yet its mechanisms and biomarkers remain unclear. This study explored the relationships among gene expression, brain metabolism, sleep deprivation, and sex …
View article: ATP5A1 as a potential prognostic biomarker in clear-cell renal cell carcinoma
ATP5A1 as a potential prognostic biomarker in clear-cell renal cell carcinoma Open
Collectively, this study indicates that ATP5A1 may serve as a potential biomarker for the diagnosis, prognosis, and therapeutic targeting of ccRCC.
View article: The Pathogenesis and Prevention Strategies of Radiation-Induced Brain Injury.
The Pathogenesis and Prevention Strategies of Radiation-Induced Brain Injury. Open
Radiation-induced brain injury (RBI) encompasses the severe symptoms resulting from radiation-induced damage to the normal tissue surrounding tumors in patients undergoing radiotherapy for head and neck malignancies. The primary symptoms i…
View article: D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis
D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis Open
Renal tubular cells may actively participate in fibrosis processes leading to end-stage renal failure. However, which molecule play pivotal role in the fibrogenesis is still vague. Glucuronyl C5-epimerase ( Hsepi , gene name, Glce ) is a k…
View article: EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication
EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication Open
Efficient DNA replication requires highly coordinated programs for the timely recruitment of protein complexes to DNA replication forks. Defects in this process result in replication stress, which in turn activates cell cycle checkpoints, …
View article: Atypical pulmonary thromboembolism caused by the mutation site SERPINC1 of the antithrombin III gene: A case report
Atypical pulmonary thromboembolism caused by the mutation site SERPINC1 of the antithrombin III gene: A case report Open
Background: Deficiency of natural anticoagulant antithrombin was first reported as a genetic risk factor for venous thromboembolism, antithrombin III (AT III) is encoded by the serpin family C member 1 ( SERPINC1 ) gene, consisting of 432 …
View article: Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity
Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity Open
Citation: Wu J, Rong Y, Li T, Wilson CM, He Y, Chen D, Han J and Zhang X (2024) Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity. Front. Immunol. 15:1412057. doi: 10.3389/fimmu.2024.1412057
View article: The crosstalk between benign thyroid disease and breast cancer: A single center study
The crosstalk between benign thyroid disease and breast cancer: A single center study Open
This study aims to investigate the relationship between benign thyroid disease and breast cancer. The clinical study includes a total of 600 participants, divided into 2 groups: the control group (N = 300), which consists of individuals fr…
View article: Left ventricular global longitudinal strain using a novel fully automated method: A head-to-head comparison with a manual layer-specific strain and establishment of normal reference ranges
Left ventricular global longitudinal strain using a novel fully automated method: A head-to-head comparison with a manual layer-specific strain and establishment of normal reference ranges Open
Using the novel automated method, was LV GLS higher than when using the manual GLS method. The normal ranges of automated GLS stratified according to sex and age were provided, with dominant determinants showing sex disparities that requir…
View article: A real-world clinicopathological model for predicting pathological complete response to neoadjuvant chemotherapy in breast cancer
A real-world clinicopathological model for predicting pathological complete response to neoadjuvant chemotherapy in breast cancer Open
Purpose This study aimed to develop and validate a clinicopathological model to predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients and identify key prognostic factors. Methods This retr…
View article: WITHDRAWN: AMPK α Succinylation modification of protein K266 enhances lipid metabolism and promotes growth of non-small cell lung cancer cells
WITHDRAWN: AMPK α Succinylation modification of protein K266 enhances lipid metabolism and promotes growth of non-small cell lung cancer cells Open
Objective: The succinylation level of the AMPKα1 protein at K266 is higher in non-small cell lung cancer tissues than normal tissues, but its relationship with NSCLC development is unclear and thus needs to be investigated. Methods: AMPKα1…
View article: Pharmacological profiling of a berbamine derivative for lymphoma treatment
Pharmacological profiling of a berbamine derivative for lymphoma treatment Open
Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) has been identified as a potential target for treating cancer. Based on our previous study of berbamine (BBM) as a CAMKIIγ inhibitor, we have synthesized a new BBM derivative termed P…
View article: PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling
PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling Open
Background Phospholipase C Delta 3 (PLCD3) is a member of phospholipase C(PLC) Protein and PLCD3 protein plays a prominent role in many cancers. However, little is known about the role of PLCD3 in esophageal squamous cell carcinoma (ESCC).…