Explanipedia

Ivonescimab for EGFR-mutant lung adenosquamous carcinoma after multiline therapy: A case report Open

Haiping Hao, Wei Zhu · 2025

This case report describes a 51-year-old male with advanced Epidermal Growth Factor Receptor (EGFR) mutant (p.T790M and p.L858R) lung adenosquamous carcinoma who achieved a rapid partial response (PR) to ivonescimab monotherapy following p…

Symmetric brain-liver circuits mediate lateralized regulation of hepatic glucose output Open

Zhonglong Wang, Xiangfei Gong, Li Jiang, Ke Wang, Xin‐Yuan Sun , et al. · 2025

Hemispheric lateralization is well recognized in regulating contralateral somatic movement, yet its relevance to visceral organ regulation remains poorly understood. This study aims to investigate whether cerebral hemispheres differentiall…

The efficacy and safety of the method of eliminating dampness and removing dampness in the treatment of gouty arthritis: a systematic review and Meta analysis based on randomized controlled trials Open

Yongdong Yang, Luchun Xu, Haiping Hao, Zeyu Li, Guozheng Jiang , et al. · 2025

Correction: Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation Open

Chengcheng Yu, Yinan Wu, Hanxu Huang, Xiumao Li, Jingkai Wang , et al. · 2025

[This corrects the article DOI: 10.3389/fimmu.2025.1550249.].

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity Open

Lichen Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan · 2025

Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing…

A rare case of repetitive bilateral suprachoroidal expulsive hemorrhage after anti-glaucoma surgeries Open

Xian Zhang, Yangyang Du, Yangyang Du, Ke Liu, Yun Li , et al. · 2025

Up-regulation of blood-circulating TIM-4-expressing monocytes and potential diagnostic biomarker sTIM-4 in primary liver cancer Open

Yifeng Yang, Wei Yan, Yilian Zhao, Haiping Hao, Dan Zeng , et al. · 2025

Integrated plasma and red blood cell membrane lipidomics analysis unveils novel biomarker panel for Alzheimer’s disease Open

Dandan He, Yong Bao, S. C. Yuan, Wang Ying-ji, Jinling Cai , et al. · 2025

Respiratory syncytial virus infection confers heterologous protection against SARS-CoV-2 via induction of γδ T cell-mediated trained immunity and SARS-CoV-2 reactive mucosal T cells Open

Awadalkareem Adam, Wenzhe Wu, Melina Jones, Haiping Hao, Aditi Aditi , et al. · 2025

SUMMARY The respiratory viruses can concurrently or sequentially infect a host and influence the trajectory of each other. The underlying immune mechanisms are not well understood. Here, we investigated whether respiratory syncytial virus …

Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation Open

Chengcheng Yu, Yinan Wu, Hanxu Huang, Xiumao Li, Jingkai Wang , et al. · 2025

Background Traditional Chinese medicine and food deer antler has been extensively used in bone regeneration, but its molecular mechanisms remain poorly understood. Preliminary investigations suggest deer antler contains bioactive compounds…

Raising Awareness: The Role of Microplastics in Pancreatic Duct Calculi Open

Wanshun Li, Jiayu Li, Yi Lu, Lixiang Wang, Zhenghui Yang , et al. · 2025

Front Cover Open

Hong Lin, Xiaojing Jia, Yue Yin, Mian Li, Ruizhi Zheng , et al. · 2025

The cover image is based on the article Association of body roundness index with cardiovascular disease and all‐cause mortality among Chinese adults by Hong Lin et al., https://doi.org/10.1111/dom.16272 . image

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance Open

Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Haiping Hao , et al. · 2025

Advances in electrochemical biosensors for the detection of tumor-derived exosomes Open

Jun Chen, Haiping Hao, Hong-Lin Zhu, Xiaobing Li · 2025

Exosomes, released from diverse cells as nanoscale lipid bilayer vesicles, mediate intercellular communication and participate in various physiological and pathological processes. Thereinto, tumor-derived exosomes (T-EXOs) with molecular c…

Transcriptome Analysis Reveals the Pivotal Genes and Regulation Pathways Under Cold Stress and Identifies SbERF027, an AP2/ERF Gene That Confers Cold Tolerance in Sorghum Open

Qijin Lou, Peng Wang, Miao Yu, Zhiqin Xie, Xu Chen , et al. · 2025

Low temperature at the seedling stage adversely affects sorghum growth and development and limits its geographical distribution. APETALA2/Ethylene-Responsive transcription factors (AP2/ERFs), one of the largest transcription factor familie…

Transient Cross-linking Mass Spectrometry: Taking Conformational Snapshots of Proteins Open

Yuxin Xie, Jiawen Wang, Lei Yang, Junjun Tao, Yuanyuan Xu , et al. · 2025

The dynamic nature of protein conformations is central to their biological functions. Conventional structural biology techniques provide static snapshots, whereas a comprehensive understanding requires an analysis of the dynamic conformati…

Trajectory Prediction for Autonomous Driving of New Energy Vehicles based on Graph Transformer Networks Open

Haiping Hao, Dongjing Chen · 2025

Accurate trajectory prediction is crucial for ensuring the safe and efficient operation of autonomous vehicles, especially in complex and dynamic traffic environments. In this paper, we propose a novel approach for trajectory prediction in…

Methylcobalamin protects against liver failure via engaging gasdermin E Open

Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin , et al. · 2025

Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12…

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis Open

Li Shi, Chen Hao, Y. Zhang, Donghao An, Mengyao Qin , et al. · 2025

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain poorly defined. Here, we screened metabolic…

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions Open

Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang , et al. · 2025

Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine Open

Zhaomin Dong, Zhiwei Zhang, Ying Peng, Zhi-Liang Chen, Leilei Lin , et al. · 2025

Versatile Framework for Song Generation with Prompt-based Control Open

Yu Zhang, Wenxiang Guo, Changhao Pan, Zhiyuan Zhu, Ruiqi Li , et al. · 2025

Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer Formation Open

Tao Li, Yuxiang Fei, Xu Sun, Jun Zhu, Xin Fang , et al. · 2025

PLN competitively binds with AXIN2 to increase β-catenin activity in CAFs. β-catenin signal induces GREM1 secretion, driving EMT and angiogenesis via BMP2 and VEGFR2, respectively. These findings demonstrate that PLN is a driver for CMS4 f…

Novel High-Performance Flexible Piezoelectric Sensors Based on P-Pvdf/Mos₂ Bead Films for Self-Powered Human Motion Monitoring Open

Dawei Gao, Haixiang Wang, Qiong Lu, Haiping Hao, Lili Wang · 2025

Discipline development and perspectives of analytical pharmacology Open

Haiping Hao, Su Zeng · 2025

Effect of Y on Hot Deformation Behavior and Recrystallization Behavior of As-Cast Ni-Cr-Al Alloy Open

Yijie Zhang, Xingchuan Xia, Junyi Luo, Zhigang Wang, Haomin Feng , et al. · 2025

75% ethanol disinfection preserves biocompatibility and mechanical properties of swim bladder for cardiovascular applications Open

Jiaji Pan, Haiping Hao, Qin Li, S. Chen, Xiaoping Ning , et al. · 2025

75% ethanol is an effective disinfectant for swim bladder biomaterials, preserving biocompatibility, ECM structure, and mechanical properties after rinsing. These findings support the use of swim bladder-derived scaffolds in cardiovascular…

Shared interaction pathways of ligands targeting the ligand-binding pocket of nuclear receptors Open

Sutong Xiang, Zhe Wang, Qirui Deng, Rongfan Tang, Qinghua Wang , et al. · 2024

Research on the application of functional near-infrared spectroscopy in differentiating subjective cognitive decline and mild cognitive impairment Open

Zheng Wang, Chen Niu, Yong Duan, Hao Yang, Jun-Xian Mi , et al. · 2024

Introduction Alzheimer’s disease (AD) is a common neurological disorder. Based on clinical characteristics, it can be categorized into normal cognition (NC), subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia…

Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders Open

Yangliu Xia, Yang Zhang, Zhipeng Zhang, Nana Yan, Vorthon Sawaswong , et al. · 2024

Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the rate-limiting step of de novo lipogenesis and modulates lipid homeostasis. Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in preclinical and …

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