Hao Zhang
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View article: Magnetic resonance‐guided split‐course hypo‐fractionated radiotherapy with concurrent chemotherapy and consolidative immunotherapy in locally advanced non–small cell lung cancer: A single arm, phase 2 study
Magnetic resonance‐guided split‐course hypo‐fractionated radiotherapy with concurrent chemotherapy and consolidative immunotherapy in locally advanced non–small cell lung cancer: A single arm, phase 2 study Open
Background To evaluate the efficacy and safety of magnetic resonance (MR)‐guided split‐course hypo‐fractionated radiotherapy (hypo‐RT) with concurrent chemotherapy followed by consolidative immunotherapy (CIT) in locally advanced non–small…
View article: Metatranscriptomic analysis of the gut virome in Muscovy ducks reveals a novel duck reovirus potentially associated with hepatic and splenic hemorrhage
Metatranscriptomic analysis of the gut virome in Muscovy ducks reveals a novel duck reovirus potentially associated with hepatic and splenic hemorrhage Open
Introduction Ducks rank among the most important sources of animal protein globally, yet hepatic and splenic hemorrhage and necrosis in Muscovy ducks present a critical challenge to the poultry industry. The causes behind such diseases are…
View article: A novel biomarker Ins60/ApoA for predicting diabetic kidney disease in newly diagnosed type 2 diabetes: a pilot study
A novel biomarker Ins60/ApoA for predicting diabetic kidney disease in newly diagnosed type 2 diabetes: a pilot study Open
Objective We performed this cross-sectional study to explore potential biomarkers for predicting diabetic kidney disease (DKD) in newly diagnosed type 2 diabetes mellitus (T2DM). Methods A total of 623 patients were recruited from Xuzhou F…
View article: Association between atorvastatin and sarcopenia: a study based on NHANES and FAERS databases
Association between atorvastatin and sarcopenia: a study based on NHANES and FAERS databases Open
Post-marketing surveillance data suggest a potential link between atorvastatin use and sarcopenia. However, further large-scale observational studies are needed to confirm this preliminary finding. This study aims to comprehensively invest…
View article: Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease
Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease Open
The glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD). Modulating cerebrospinal fluid (CSF)-based clearance and targ…
View article: Correlation between gabapentin and depression: A study from the NHANES and FAERS databases
Correlation between gabapentin and depression: A study from the NHANES and FAERS databases Open
Post-marketing surveillance has indicated an association between gabapentin use and an increased risk of depression. However, observational findings on this relationship have been inconsistent. This study aims to investigate the correlatio…
View article: Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery
Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery Open
Background Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolyt…
View article: Association Between Atorvastatin and Sarcopenia: A Study Based on NHANES and FAERS Databases
Association Between Atorvastatin and Sarcopenia: A Study Based on NHANES and FAERS Databases Open
Background Post-marketing surveillance data suggest a potential link between atorvastatin use and sarcopenia. However, further large-scale observational studies are needed to confirm this preliminary finding. Objective This study aims to c…
View article: Expression and clinical significance of AUF1 and HIF-1α in papillary thyroid carcinoma
Expression and clinical significance of AUF1 and HIF-1α in papillary thyroid carcinoma Open
AUF1 and HIF-1α may work in concert to accelerate the development of PTC. And they may be useful biomarkers for PTC and lymph node metastases.
View article: Multicenter analysis of radioactive iodine therapy outcomes after total thyroidectomy for T1-T2 stage papillary thyroid carcinoma with cervical lymph node metastasis in China
Multicenter analysis of radioactive iodine therapy outcomes after total thyroidectomy for T1-T2 stage papillary thyroid carcinoma with cervical lymph node metastasis in China Open
Background: The optimal approach for radioactive iodine (RAI) therapy of T1-T2 stage papillary thyroid carcinoma (PTC) with cervical lymph node metastasis following total thyroidectomy (TT) remains unclear. This study aimed to provide indi…
View article: Comparison of total thyroidectomy and lobectomy for intermediate-risk papillary thyroid carcinoma with lateral lymph node metastasis: a systematic review and meta-analysis
Comparison of total thyroidectomy and lobectomy for intermediate-risk papillary thyroid carcinoma with lateral lymph node metastasis: a systematic review and meta-analysis Open
Background: The 2015 American Thyroid Association guidelines recommend total thyroidectomy (TT) followed by radioactive iodine (RAI) therapy as the primary treatment modality for intermediate-risk papillary thyroid carcinoma (PTC) patients…
View article: A protein-based classifier for differentiating follicular thyroid adenoma and carcinoma
A protein-based classifier for differentiating follicular thyroid adenoma and carcinoma Open
Differentiating follicular thyroid adenoma (FTA) from carcinoma (FTC) remains challenging due to similar histological features separate from invasion. This study developed and validated DNA- and/or protein-based classifiers. A total of 244…
View article: Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV Open
A man living with HIV was found to lack expression of CD16A on his natural killer (NK) cells and monocytes. Genetic analysis revealed compound heterozygous deletion of FCGR3A , the gene encoding CD16A. The case’s NK cells showed: (a) no an…
View article: SAMA: Towards Multi-Turn Referential Grounded Video Chat with Large Language Models
SAMA: Towards Multi-Turn Referential Grounded Video Chat with Large Language Models Open
Achieving fine-grained spatio-temporal understanding in videos remains a major challenge for current Video Large Multimodal Models (Video LMMs). Addressing this challenge requires mastering two core capabilities: video referring understand…
View article: The potential of chimeric antigen receptor -T cell therapy for endocrine cancer
The potential of chimeric antigen receptor -T cell therapy for endocrine cancer Open
Endocrine cancer, a relatively rare and heterogeneous tumor with diverse clinical features. The facile synthesis of hormones further complicates endocrine cancer treatment. Thus, the development of safe and effective systemic treatment app…
View article: CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression
CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression Open
The dynamic interplay between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer (ATC) shapes the tumor microenvironment and facilitates ATC progression. However, the mechanisms of communication between TAMs and anaplastic t…
View article: UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation
UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation Open
Integrating single‐cell datasets from multiple studies provides a cost‐effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integ…
View article: Nomograms of risk prediction and prognosis for the T1-T2 stage gastric cancer with lymph node metastasis: a population-based study
Nomograms of risk prediction and prognosis for the T1-T2 stage gastric cancer with lymph node metastasis: a population-based study Open
Background and aims Lymph node metastasis plays a crucial role in determining the appropriate treatment approach for patients with gastric cancer (GC), particularly those in the T1–T2 stage. Currently available diagnostic strategies for GC…
View article: Chinese Expert Consensus on Preventing and Managing Chyle Fistula in Cervical Lymph Node Dissection for Thyroid Cancer (2024)
Chinese Expert Consensus on Preventing and Managing Chyle Fistula in Cervical Lymph Node Dissection for Thyroid Cancer (2024) Open
This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the management of chyle fistula.
View article: Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer
Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer Open
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, an…
View article: Case report: Long remission and survival following immunotherapy in a case of pulmonary pleomorphic carcinoma
Case report: Long remission and survival following immunotherapy in a case of pulmonary pleomorphic carcinoma Open
In 2020, we reported on a case involving a 68-year-old male patient with a rare instance of pulmonary pleomorphic carcinoma exhibiting high PD-L1 expression. The patient experienced significant therapeutic success with the use of pembroliz…
View article: Tumor differentiation-dependent conditional survival of patients with operable thyroid cancer
Tumor differentiation-dependent conditional survival of patients with operable thyroid cancer Open
Objective Little is known about the changing risk profile of death and conditional survival in patients with operable thyroid cancer. This study aimed to investigate the annual hazard rate of cancer death, actuarial disease-specific surviv…
View article: Mechanistic insights into traditional Chinese medicine for digestive tract cancers: implications for gastric, hepatic, esophageal, intestinal, and pancreatic tumors
Mechanistic insights into traditional Chinese medicine for digestive tract cancers: implications for gastric, hepatic, esophageal, intestinal, and pancreatic tumors Open
The increasing incidence of cancer-related deaths highlights the pressing need for effective treatment modalities, particularly in the context of digestive tract cancers, such as gastric, hepatic, esophageal, intestinal, and pancreatic tum…
View article: CXCL12 regulates breast cancer metastasis and T lymphocyte infiltration
CXCL12 regulates breast cancer metastasis and T lymphocyte infiltration Open
Purpose: Breast cancer (BC) is a malignant tumor with the highest incidence rate in women. This work explored the function of CXCL12 in tumor metastasis. Methods: CXCL12 protein expression levels were assessedby IHC in breast cancer tissue…
View article: Rethinking the prognosis model of differentiated thyroid carcinoma
Rethinking the prognosis model of differentiated thyroid carcinoma Open
Background The prediction efficiency of long-term cancer-specific survival (CSS) in guiding the treatment of differentiated thyroid carcinoma (DTC) patients is still unsatisfactory. We need to refine the system so that it more accurately c…
View article: Bmal1 upregulates ATG5 expression to promote autophagy in skin cutaneous melanoma
Bmal1 upregulates ATG5 expression to promote autophagy in skin cutaneous melanoma Open
This study concluded that Bmal1 is a novel biomarker that functions as both a diagnostic and prognostic indicator for the progression of SKCM.