Heng Cui
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View article: Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer Open
Taken together, these findings highlight that SREBP-1 is an effective therapeutic target in GC and that Pen-H is a promising SREBP-1 inhibitor and a candidate for GC treatment.
View article: Comparison of the anesthetic efficacy and recovery quality of remimazolam besylate versus sevoflurane for pediatric circumcision: a single-center, prospective, assessor-blinded, randomized controlled study protocol
Comparison of the anesthetic efficacy and recovery quality of remimazolam besylate versus sevoflurane for pediatric circumcision: a single-center, prospective, assessor-blinded, randomized controlled study protocol Open
Background Administering anesthesia for circumcision in children involves prioritizing safety, comfort, and quality of recovery. While the effectiveness of remimazolam besylate in pediatric anesthesia requires additional confirmation, sevo…
View article: Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making
Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making Open
Background Remimazolam's role in pediatric anesthesia is evolving. We systematically reviewed 2024–2025 evidence to establish a clinical decision-making framework for its use. Methods Following PRISMA guidelines, a systematic search identi…
View article: Charting the future of precision management for visceral traction response in caesarean delivery: a scoping review and evidence mapping protocol
Charting the future of precision management for visceral traction response in caesarean delivery: a scoping review and evidence mapping protocol Open
Background The visceral traction response (VTR) occurring during caesarean sections with neuraxial anaesthesia represents a common and significant complication that can greatly affect perioperative results and maternal contentment. Traditi…
View article: Remimazolam for anesthesia and sedation in pediatric ambulatory surgery: A scoping review protocol
Remimazolam for anesthesia and sedation in pediatric ambulatory surgery: A scoping review protocol Open
Background Remimazolam, an innovative benzodiazepine, exhibits potential for use in anesthesia and sedation for pediatric outpatient procedures, due to its rapid onset, predictable metabolism, and favorable safety profile. While adult stud…
View article: Fear of cancer recurrence and influencing factors in elderly patients with gastric cancer undergoing laparoscopic radical surgery
Fear of cancer recurrence and influencing factors in elderly patients with gastric cancer undergoing laparoscopic radical surgery Open
BACKGROUND Fear of cancer recurrence (FCR) is a common psychological problem among patients with cancer, especially elderly patients. For patients with gastric cancer (GC) who have undergone treatments such as surgery, FCR may seriously af…
View article: Current status of pharmacotherapy for primary sclerosing cholangitis
Current status of pharmacotherapy for primary sclerosing cholangitis Open
Primary sclerosing cholangitis (PSC) represents a cholestatic disease hallmarked by persistent and progressive inflammation of the bile ducts. Despite its low incidence and unfavorable prognosis, there is no pharmacological therapy capable…
View article: Comparison of the Anesthetic Efficacy and Recovery Quality of Remimazolam Besylate versus Sevoflurane for Pediatric Circumcision: A Single-Center, Prospective, Randomized Controlled Study Protocol
Comparison of the Anesthetic Efficacy and Recovery Quality of Remimazolam Besylate versus Sevoflurane for Pediatric Circumcision: A Single-Center, Prospective, Randomized Controlled Study Protocol Open
Background: Administering anesthesia for circumcision in children involves prioritizing safety, comfort, and quality of recovery. While the effectiveness of remimazolam besylate in pediatric anesthesia requires additional confirmation, sev…
View article: The improved interpolating element-free Galerkin method with nonsingular weight functions for 3D Schrödinger equations
The improved interpolating element-free Galerkin method with nonsingular weight functions for 3D Schrödinger equations Open
In this study, the improved interpolating element-free Galerkin (IIEFG) method with a nonsingular weight function for solving the 3D Schrödinger equations is presented. We apply the improved interpolating moving least-squares (IIMLS) metho…
View article: Gender differences in oxyhemoglobin (oxy-Hb) changes during drawing interactions in romantic couples: an fNIRS study
Gender differences in oxyhemoglobin (oxy-Hb) changes during drawing interactions in romantic couples: an fNIRS study Open
Interpersonal interaction is essential to romantic couples. Understanding how gender impacts an individual’s brain activities during intimate interaction is crucial. The present study examined gender differences in oxyhemoglobin (oxy-Hb) c…
View article: Near-infrared fluorescent molecular probes with cetuximab in the in vivo fluorescence imaging for epithelial ovarian cancer
Near-infrared fluorescent molecular probes with cetuximab in the in vivo fluorescence imaging for epithelial ovarian cancer Open
Cetuximab-Cy7 can specifically target the tumors of EOC xenografted nude mice. This research lays the foundation for future studies on EOC surgery navigation.
View article: Niraparib maintenance therapy using an individualised starting dose in patients with platinum-sensitive recurrent ovarian cancer (NORA): final overall survival analysis of a phase 3 randomised, placebo-controlled trial
Niraparib maintenance therapy using an individualised starting dose in patients with platinum-sensitive recurrent ovarian cancer (NORA): final overall survival analysis of a phase 3 randomised, placebo-controlled trial Open
Zai Lab (Shanghai) Co., Ltd; National Major Scientific and Technological Special Project for "Significant New Drugs Development" in 2018, China [grant number 2018ZX09736019].
View article: Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer
Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer Open
Background: High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because of its extremely metastatic nature. This study aimed to explore and evaluate the characteristics of candidate facto…
View article: Preliminary Safety and Potential Effect of 6B11-OCIK Adoptive Cell Therapy Against Platinum-Resistant Recurrent or Refractory Ovarian Cancer
Preliminary Safety and Potential Effect of 6B11-OCIK Adoptive Cell Therapy Against Platinum-Resistant Recurrent or Refractory Ovarian Cancer Open
Ovarian cancer is a leading cause of death among gynecological malignancies, and novel therapies are urgently needed. Here we report preliminary findings on the potential safety and efficacy of 6B11-OCIK, an adoptive cell therapy of autolo…
View article: Real-world Experience of Olaparib Treatment in Patients with Ovarian Cancer: A Chinese Multicenter Study
Real-world Experience of Olaparib Treatment in Patients with Ovarian Cancer: A Chinese Multicenter Study Open
The objective of this study was to evaluate the real-world application, efficacy, and safety data of olaparib for maintenance therapy and active treatment in patients with ovarian cancer in China. Patients with ovarian cancer from 17 insti…
View article: Characterization of Candidate Factors Associated With the Metastasis and Progression of High Grade Serous Ovarian Cancer
Characterization of Candidate Factors Associated With the Metastasis and Progression of High Grade Serous Ovarian Cancer Open
Background . High grade serous ovarian cancer (HGSOC) is the highest cause of gynecological cancer-related mortality due to the extremely metastatic nature of this disease. The goal of this study is to explore and evaluate the profiles and…
View article: Treatment of liver metastases in patients with epithelial ovarian cancer
Treatment of liver metastases in patients with epithelial ovarian cancer Open
To the Editor: The liver is one of the most vulnerable organs of metastatic tumors. A metastatic tumor of the liver is about 18 to 40 times more common than a primary liver tumor (LM). There are approximately 50,000 new ovarian cancer pati…
View article: Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling
Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling Open
Meili Zhao,1,2 Yangyang Sun,3 Zhen Gao,3 Hongqiu Cui,1,2 Jianbin Chen,1,2 Meina Wang,1,2 Zhicai Wang1– 3 1Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization (Shenzhen), Shenzhen 5…
View article: Real-World Effectiveness and Safety of Antipsychotics in Individuals at Clinical High-Risk for Psychosis: Study Protocol for a Prospective Observational Study (ShangHai at Risk for Psychosis-Phase 2)
Real-World Effectiveness and Safety of Antipsychotics in Individuals at Clinical High-Risk for Psychosis: Study Protocol for a Prospective Observational Study (ShangHai at Risk for Psychosis-Phase 2) Open
GuiSen Wu,1 RanPiao Gan,1 ZhiXing Li,1 LiHua Xu,1 XiaoChen Tang,1 YanYan Wei,1 YeGang Hu,1 HuiRu Cui,1 HuiJun Li,2 YingYing Tang,1 Li Hui,3 XiaoHua Liu,1 ChunBo Li,1 JiJun Wang,1,4,5 TianHong Zhang1 1Shanghai Mental Health Center, Shanghai…
View article: Hydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats
Hydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats Open
Xiaolong Liu,1,* Haiyan Cui,2,* Hongling Niu,1 Liping Wang,3 Xiangzhi Li,1 Jingbo Sun,1 Qingzhu Wei,4 Jianghui Dong,3 Lixin Liu,1 Cory J Xian3 1Department of General Surgery, The Third Affiliated Hospital of Southern Medical University, Gu…