Hesong Zeng
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Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex Open
In metabolic dysfunction‐related steatohepatitis (MASH), ITGB3 promotes hepatic fibrosis via activating hepatic stellate cells, but whether it directly regulates hepatic lipid metabolism through membrane‐scaffolding function and the underl…
Complement C3 in panvascular disease: a central integrator of immune signaling and vascular remodeling Open
Panvascular disease, defined by the systemic involvement of multiple vascular beds, poses a growing challenge to contemporary diagnostic and therapeutic paradigms. Despite organ-specific manifestations, these conditions share a convergent …
View article: Complement C3/C3a-CCL9 feedback loop orchestrates inflammatory crosstalk to accelerate aortic dissection
Complement C3/C3a-CCL9 feedback loop orchestrates inflammatory crosstalk to accelerate aortic dissection Open
Aortic dissection (AD) is a life-threatening vascular disease marked by severe inflammation and immune cell infiltration. While complement activation has been implicated, the specific roles of complement component 3 (C3) and its active fra…
Clinical Characteristics and Prognosis in Spontaneous Isolated Abdominal Aortic Dissection Based on the Dissection Length Open
Objective: The purpose of this study was to report the clinical characteristics and prognosis of spontaneous isolated abdominal aortic dissection (SIAAD) based on the dissection length. Methods: Between March 2012 and September 2023, 159 o…
View article: <b>Activated protein C </b><b>suppresses cardiomyocyte senescence</b><b> in diabetic cardiomyopathy via </b><b>PAR1/PAR3-P85-CaMKIIδ axis</b>
<b>Activated protein C </b><b>suppresses cardiomyocyte senescence</b><b> in diabetic cardiomyopathy via </b><b>PAR1/PAR3-P85-CaMKIIδ axis</b> Open
Diabetic cardiomyopathy (DbCM) is a chronic metabolic disorder with few effective treatment strategies. Our previous study demonstrated that activated protein C (aPC), a serine protease, exerts cytoprotective effects in DbCM. However, the …
Applications of Ballistocardiogram in the Diagnosis of Coronary Heart Disease: Systematic Review Open
Background Coronary heart disease (CHD) continues to account for a substantial proportion of deaths worldwide. Ballistocardiogram (BCG), a noncontact, noninvasive technique for monitoring cardiac activity, has gained increasing attention f…
View article: Prognostic implications of left ventricular mechanical dispersion in comparison with QRS duration in heart failure with reduced ejection fraction
Prognostic implications of left ventricular mechanical dispersion in comparison with QRS duration in heart failure with reduced ejection fraction Open
In HFrEF patients with medical treatment, LV-MD provides additional information on left ventricular dyssynchrony and has superior prognostic value for left ventricular reverse remodeling compared with QRS duration alone.
View article: A novel framework for fully-automated co-registration of intravascular ultrasound and optical coherence tomography imaging data
A novel framework for fully-automated co-registration of intravascular ultrasound and optical coherence tomography imaging data Open
Aims: To develop a deep-learning (DL) framework that will allow fully automated longitudinal and circumferential co-registration of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images. Methods and results: Data fr…
Left Ventricular Mechanical Dispersion and Its Value in Combination With Global Longitudinal Strain to Predict Reverse Remodeling in Patients With Heart Failure With Reduced Ejection Fraction Open
Background Left ventricular mechanical dispersion (LV‐MD), an indicator of LV dyssynchrony, is not well studied in heart failure with reduced ejection fraction (HFrEF). This study aims to investigate the profile of LV‐MD in HFrEF, and eval…
Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients Open
Six immunoinflammatory markers demonstrated significant associations with CHD risk in NAFLD populations, among which the NHR index exhibited particularly promising predictive potential.
View article: AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling
AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling Open
Aortic dissection (AD), a life-threatening cardiovascular emergency, continues to impose high mortality due to insufficient therapeutic options, as monotherapy targeting angiotensin II type 1 receptor (AT1R) demonstrates limited clinical e…
View article: Association of thrombocytopenia and D-dimer elevation with in-hospital mortality in acute aortic dissection
Association of thrombocytopenia and D-dimer elevation with in-hospital mortality in acute aortic dissection Open
Our analysis revealed associations between changes in platelet count, PT, PTA, TT, fibrinogen and D-dimer levels and outcomes in patients with AAD. Furthermore, the combined effect of thrombocytopenia and high D-dimer levels significantly …
View article: An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study
An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study Open
Current tools for predicting the thrombolysis risk in patients after stroke exhibit limited event prediction in early post-thrombolysis hemorrhagic events. This highlights an unmet medical need to improve the tools for stroke management. W…
View article: Extended Clopidogrel Monotherapy vs DAPT in Patients With Acute Coronary Syndromes at High Ischemic and Bleeding Risk
Extended Clopidogrel Monotherapy vs DAPT in Patients With Acute Coronary Syndromes at High Ischemic and Bleeding Risk Open
Importance Purinergic receptor P2Y12 (P2Y12) inhibitor monotherapy after a certain period of dual antiplatelet therapy (DAPT) may be an attractive option of maintenance antiplatelet treatment for patients undergoing percutaneous coronary i…
A novel complement C3 inhibitor CP40-KK protects against experimental pulmonary arterial hypertension via an inflammasome NLRP3 associated pathway Open
Background Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by complement dependent and proinflammatory activation of macrophages. However, effective treatment for complement activation in PAH is lack…
View article: Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry Open
Real-world data on effectiveness and safety of a single non-vitamin K antagonist oral anticoagulant in the Chinese population with atrial fibrillation (AF) are limited. This study reports characteristics of patients treated with edoxaban a…
Effects of perioperative exercise on cardiorespiratory endurance in children with congenital heart disease in plateau areas after surgical repair Open
We aimed to explore the effects of perioperative exercise on cardiorespiratory endurance in children with congenital heart disease (CHD) in plateau areas after surgical repair. Fifty children with CHD in the plateau admitted to our hospita…
A nomogram for predicting echocardiogram prescription in outpatients: an analysis of the NAMCS database Open
Background and objective Cardiovascular disease is the leading cause of morbidity and mortality globally. Echocardiography is a commonly used method for assessing the condition of patients with cardiovascular disease. However, little is kn…
Application and risk prediction of thrombolytic therapy in cardio-cerebrovascular diseases: a review Open
Cardiocerebrovascular diseases (CVDs) are the leading cause of death worldwide, consuming huge healthcare budget. For CVD patients, the prompt assessment and appropriate administration is the crux to save life and improve prognosis. Thromb…
ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy <i>via</i> restraining endothelial–mesenchymal transition Open
Diabetic cardiomyopathy (DCM) is a chronic metabolic disease with few effective therapeutic options. Immunoproteasome is an inducible proteasome that plays an important role in the regulation of many cardiovascular diseases, while its role…
[Corrigendum] A potential therapeutic effect of CYP2C8 overexpression on anti‑TNF‑α activity Open
Following the publication of the above article, an interested reader drew to the authors' attention that, for the cell migration assay experiments shown in Fig. 5 on p. 731, the 'TNF‑α' data panels in Fig. 5A and C appeared to be matching,…
sGC agonist BAY1021189 promotes thoracic aortic dissection formation by accelerating vascular smooth muscle cell phenotype switch Open
Thoracic aortic dissection (TAD) is common but lethal cardiovascular disease with high mortality. This study aimed to expound whether and how sGC-PRKG1 signaling pathway might promote the formation of TAD. Our work identified two modules w…
One-stop interventional procedure for bicuspid aortic stenosis in a patient with coexisting aortic coarctation: a case report Open
Introduction Coarctation of the aorta (CoA) is usually diagnosed and corrected early in life. Most untreated patients with CoA usually die before 50 years of age. Adult patients with concomitant CoA and severe bicuspid aortic stenosis are …
PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis Open
Pulmonary arterial hypertension (PAH) is a group of severe, progressive, and debilitating diseases with limited therapeutic options. This study aimed to explore novel therapeutic targets in PAH through bioinformatics and experiments. Weigh…
Bioinformatics analysis reveals the potential role of matrix metalloproteinases in immunity and urolithiasis Open
Background The pathogenesis of urolithiasis remains unclear, making the development of medications for treatment and prevention stagnant. Randall’s plaques (RPs) begin as interstitial calcium phosphate crystal deposits, grow outward and br…
Association of lymphopenia and RDW elevation with risk of mortality in acute aortic dissection Open
Objective The study aimed to investigate whether lymphopenia and red blood cell distribution width (RDW) elevation are associated with an increased risk of mortality in acute aortic dissection (AAD). Methods This multicenter retrospective …
Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals Open
Background Proper prognostic biomarker is of great importance for clinical decision-making in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Although recently emerges plenty of novel in…