Haochen Xuan
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View article: Prognostic Impact of Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Coronary Ischemia: A Retrospective Cohort Study
Prognostic Impact of Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Coronary Ischemia: A Retrospective Cohort Study Open
SGLT2 inhibitors were found to be associated with a reduced risk of 3-year MACE and all-cause mortality in patients with T2DM and coronary ischemia, regardless of extent of revascularization.
View article: Clinical Outcomes in Patients With Quadricuspid vs Bicuspid Aortic Valve
Clinical Outcomes in Patients With Quadricuspid vs Bicuspid Aortic Valve Open
Importance Congenital aortic valve disease predominantly manifests as bicuspid aortic valve (BAV), while quadricuspid aortic valve (QAV) is considerably rarer. Whether outcomes vary between these 2 types of congenital aortic valve disease …
View article: The effect of sodium‐glucose cotransporter 2 inhibitors on <scp>HbA1c</scp> variability and cardiovascular and renal adverse outcome in patients with <scp>T2DM</scp>
The effect of sodium‐glucose cotransporter 2 inhibitors on <span>HbA1c</span> variability and cardiovascular and renal adverse outcome in patients with <span>T2DM</span> Open
Aims To compare the effectiveness of sodium‐glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP‐4) inhibitors in reducing haemoglobin A1c (HbA1c) variability and improving cardiovascular and renal outcomes in patient…
View article: Prognostic Implication of Computational Angiography–Derived Fractional Flow Reserve in Patients With Nonobstructive Coronary Artery Disease
Prognostic Implication of Computational Angiography–Derived Fractional Flow Reserve in Patients With Nonobstructive Coronary Artery Disease Open
Background Risk stratification of patients with symptomatic nonobstructive coronary artery disease remains uncertain. Our study assessed the clinical value of single‐vessel, multivessel, and 3‐vessel computational angiography–derived fract…
View article: B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure
B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure Open
B-type natriuretic peptide (BNP) possesses protective cardiovascular properties; however, there has not been sufficient serious consideration of the side effects of BNP. As for sarcoplasmic/endoplasmic reticulum calcium ATPase 2a (SERCA2a)…
View article: Direct comparison of coronary microvascular obstruction evaluation using CMR feature tracking and layer-specific speckle tracking echocardiography in STEMI patients
Direct comparison of coronary microvascular obstruction evaluation using CMR feature tracking and layer-specific speckle tracking echocardiography in STEMI patients Open
Purpose Layer-specific speckle tissue echocardiography (LS-STE) is a unique technique used to assess coronary microvascular obstruction (CMVO) that may offer more information on the myocardial anatomy of patients with ST-elevation myocardi…
View article: Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010 Open
Background To explore the association of low-level lead exposure with all-cause mortality and cardiovascular disease (CVD) mortality among hypertensive patients. Methods This cohort study enrolled 6453 adults with hypertension from the Nat…
View article: The association between serum albumin and long length of stay of patients with acute heart failure: A retrospective study based on the MIMIC-IV database
The association between serum albumin and long length of stay of patients with acute heart failure: A retrospective study based on the MIMIC-IV database Open
Background The purpose of this article is to assess the relationship between serum albumin level and long length of stay (LOS) of inpatients with acute heart failure (AHF) in the intensive care unit (ICU). Methods We retrospectively analyz…
View article: Triglyceride Glucose Index Increases Significantly Risk of Hypertension Development in Chinese Individuals Aged ≥45 Years Old: Analysis from the China Health and Retirement Longitudinal Study
Triglyceride Glucose Index Increases Significantly Risk of Hypertension Development in Chinese Individuals Aged ≥45 Years Old: Analysis from the China Health and Retirement Longitudinal Study Open
TyG index was an independent hazard indicator for new-onset hypertension, and routine measurement and control of TyG index level might be great for preventing hypertension development.
View article: Luteolin Pretreatment Ameliorates Myocardial Ischemia/Reperfusion Injury by lncRNA‐JPX/miR‐146b Axis
Luteolin Pretreatment Ameliorates Myocardial Ischemia/Reperfusion Injury by lncRNA‐JPX/miR‐146b Axis Open
Background . In the present study, we aimed to find out whether luteolin (Lut) pretreatment could ameliorate myocardial ischemia/reperfusion (I/R) injury by regulating the lncRNA just proximal to XIST (JPX)/microRNA‐146b (miR‐146b) axis. M…
View article: Additional file 1 of Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
Additional file 1 of Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010 Open
Additional file 1: Supplementary Table 1. Thresholdeffect analysis of blood lead on all-cause mortality modified by age. SupplementaryTable 2. Threshold effectanalysis of blood lead on all-cause mortality modified by antidiabetic drugs. Su…
View article: The construction and analysis of m6A-related ceRNA network and patterns of immune infiltration in calcified aortic valve disease
The construction and analysis of m6A-related ceRNA network and patterns of immune infiltration in calcified aortic valve disease Open
Background Despite being the most prevalent valve heart disease among the elderly, calcified aortic valve disease (CAVD) is not adequately addressed based on its current mechanisms. N6-methyladenosine (m6A) modification is increasingly bei…
View article: Development and validation of a predictive model for adverse left ventricular remodeling in NSTEMI patients after primary percutaneous coronary intervention
Development and validation of a predictive model for adverse left ventricular remodeling in NSTEMI patients after primary percutaneous coronary intervention Open
Introduction To develop and validate clinical evaluators that predict adverse left ventricular remodeling (ALVR) in non-ST-elevation myocardial infarction (NSTEMI) patients after primary percutaneous coronary intervention (PCI). Methods Th…
View article: Comparison of Diagnostic Value Between STE+LDDSE and CMR-FT for Evaluating Coronary Microvascular Obstruction in Post-PCI Patients for STEMI
Comparison of Diagnostic Value Between STE+LDDSE and CMR-FT for Evaluating Coronary Microvascular Obstruction in Post-PCI Patients for STEMI Open
Low-dose dobutamine can improve the clinical value of STE for evaluating CMVO in STEMI patients. Compared with CMR-FT, STE+LDDSE might be a better choice for STEMI patients because of its safety, convenience, and low-cost.
View article: The association between serum albumin and LOS of patients with acute heart failure: a retrospective study based on the MIMIV-IV database
The association between serum albumin and LOS of patients with acute heart failure: a retrospective study based on the MIMIV-IV database Open
Objective: To assess the relationship between serum albumin and length of stay (LOS) of the intensive care unit (ICU). Design and Participants: we retrospectively analyze 2280 patients with acute heart failure(AHF) from the medical informa…
View article: The association between serum albumia and length of stay of intensive care units in patients with heart failure
The association between serum albumia and length of stay of intensive care units in patients with heart failure Open
Objective: To assess the relationship between serum albumia and length of stay (LOS) of the intensive care units (ICUs). Design and Participants: we retrospectively analyze 2843 patients from the medical information mart for intensive care…
View article: The expression and role of β3AR protein in myocardial ischemia/reperfusion in rats
The expression and role of β3AR protein in myocardial ischemia/reperfusion in rats Open
Introduction The aim of this study is to explore serum norepinephrine (NE) concentration and β3-adrenoceptor (β3AR) protein expression at different times during myocardial ischemia/reperfusion (I/R) in rats and to examine the role of β3AR …
View article: Efficacy and safety of low dose ticagrelor in patients with acute coronary syndrome: a systematic review and meta-analysis
Efficacy and safety of low dose ticagrelor in patients with acute coronary syndrome: a systematic review and meta-analysis Open
Our aim was to examine clinical trials, provide guidance to practitioners and estimate the efficacy and safety of two agents by comparing low dose ticagrelor with standard dose clopidogrel in patients with acute coronary syndrome. We syste…
View article: Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion
Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion Open
Background/Aims: A major challenge for current therapeutic strategies against ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) to improve …
View article: Luteolin Exerts Cardioprotective Effects through Improving Sarcoplasmic Reticulum Ca<sup>2+</sup>-ATPase Activity in Rats during Ischemia/Reperfusion In Vivo
Luteolin Exerts Cardioprotective Effects through Improving Sarcoplasmic Reticulum Ca<sup>2+</sup>-ATPase Activity in Rats during Ischemia/Reperfusion In Vivo Open
The flavonoid luteolin exists in many types of fruits, vegetables, and medicinal herbs. Our previous studies have demonstrated that luteolin reduced ischemia/reperfusion (I/R) injury in vitro, which was related with sarcoplasmic reticulum …