Hongbing Ma
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View article: Splenectomy following rituximab and cyclophosphamide for severe autoimmune hemolytic anemia in pregnancy
Splenectomy following rituximab and cyclophosphamide for severe autoimmune hemolytic anemia in pregnancy Open
Autoimmune hemolytic anemia (AIHA) in pregnancy is uncommon and intractable when it becomes steroid-refractory. Due to lacking well-established guidelines for AIHA in pregnancy, a balance must be weighed between benefits and risks. It is u…
View article: Integration of anti-PD-1 antibody into chemotherapeutic regimens improved the outcome of aggressive NK cell leukemia: a single-center retrospective real-world analysis
Integration of anti-PD-1 antibody into chemotherapeutic regimens improved the outcome of aggressive NK cell leukemia: a single-center retrospective real-world analysis Open
Background Aggressive natural killer (NK) cell leukemia (ANKL) is a rare NK cell neoplasm associated with Epstein-Barr virus (EBV) infection. Programmed cell death protein 1 (PD-1) blockade, which is successful in extranodal NK/T-cell lymp…
View article: Effect of a breathing exercise program on coronary artery motion artifacts in 256 rows of coronary computed tomography angiography in patients with different heart rate variability
Effect of a breathing exercise program on coronary artery motion artifacts in 256 rows of coronary computed tomography angiography in patients with different heart rate variability Open
The combination of a 140-ms time resolution, a 16-cm wide detector, and the second-generation reconstruction algorithm can be used jointly to realize free-breathing CCTA under different HRV conditions, which broadens the application range …
View article: The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia
The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia Open
Background Dual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be a life-threatening complication of induct…
View article: Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma: A case report and review of literature
Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma: A case report and review of literature Open
BACKGROUND Rhabdomyosarcoma of the uterine cervix is a rare form of soft-tissue sarcoma predominantly affecting young women, with no established standard treatment protocol. CASE SUMMARY This report presents a case of a 17-year-old female …
View article: Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes
Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes Open
Background Adoptive therapy with umbilical cord blood (UCB) T-regulatory (Treg) cells can prevent graft vs. host disease (GVHD). We hypothesize that UCB Tregs can treat GVHD and synergize with ruxolitinib, Jak2 inhibitor, to improve outcom…
View article: Combining azole antifungals with venetoclax plus azacitidine in patients with newly diagnosed acute myeloid leukemia
Combining azole antifungals with venetoclax plus azacitidine in patients with newly diagnosed acute myeloid leukemia Open
The combination of venetoclax (VEN) with hypomethylating agents (HMAs) improves survival in patients with acute myeloid leukemia (AML) and may cause neutropenia requiring combined antifungal therapy or prophylaxis. The inhibition of cytoch…
View article: Causal associations between constipation and pan-cancer: a bidirectional Mendelian randomization study
Causal associations between constipation and pan-cancer: a bidirectional Mendelian randomization study Open
Objective Observational studies have suggested a potential association between constipation and several cancers. However, the causal relationship between constipation and cancer remains unclear. The purpose of this study is to explore the …
View article: Intravascular large B-cell lymphoma as a covert trigger for hemophagocytic lymphohistiocytosis complicated with capillary leak syndrome: a case report and literature review
Intravascular large B-cell lymphoma as a covert trigger for hemophagocytic lymphohistiocytosis complicated with capillary leak syndrome: a case report and literature review Open
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma. Patients with hemophagocytic lymphohistiocytosis (HLH)-associated IVLBCL variants exhibit significantly poor survival. Cytokines play pivotal roles in …
View article: Sweet syndrome induced by FLT3 inhibitors: case report and literature review
Sweet syndrome induced by FLT3 inhibitors: case report and literature review Open
Attention should be given to this rare complication when FLT3 inhibitors are used for acute myeloid leukemia therapy, and appropriate treatments need to be administered in a timely manner.
View article: Targeting PRAME for acute myeloid leukemia therapy
Targeting PRAME for acute myeloid leukemia therapy Open
Despite significant progress in targeted therapy for acute myeloid leukemia (AML), clinical outcomes are disappointing for elderly patients, patients with less fit disease characteristics, and patients with adverse disease risk characteris…
View article: Standard dose anthracycline plus all-trans retinoic acid and arsenic trioxide as induction chemotherapy significantly reduces early death and relapse for high-risk acute promyelocytic leukemia: a single-center real-world analysis
Standard dose anthracycline plus all-trans retinoic acid and arsenic trioxide as induction chemotherapy significantly reduces early death and relapse for high-risk acute promyelocytic leukemia: a single-center real-world analysis Open
Background: All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have revolutionized the treatment of acute promyelocytic leukemia (APL). However, the management of high-risk APL has not been conclusively established. The optimal dosa…
View article: The clinical features and prognostic implications of <i>PTPN11</i> mutation in adult patients with acute myeloid leukemia in China
The clinical features and prognostic implications of <i>PTPN11</i> mutation in adult patients with acute myeloid leukemia in China Open
Background The clinical significance of protein tyrosine phosphatase nonreceptor type 11 mutation ( PTPN11 mut ) in acute myeloid leukemia (AML) is underestimated. Methods We collected the data of AML patients with mutated PTPN11 and wild‐…
View article: Allogeneic cord blood regulatory T cells decrease dsDNA antibody and improve albuminuria in systemic lupus erythematosus
Allogeneic cord blood regulatory T cells decrease dsDNA antibody and improve albuminuria in systemic lupus erythematosus Open
Background Lupus nephritis (LN) constitutes the most severe organ manifestations of systemic lupus erythematosus (SLE), where pathogenic T cells have been identified to play an essential role in ‘helping’ B cells to make autoantibodies and…
View article: Identifying <i>STRN3-RARA</i> as a new fusion gene for acute promyelocytic leukemia
Identifying <i>STRN3-RARA</i> as a new fusion gene for acute promyelocytic leukemia Open
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, …
View article: Zanubrutinib safety/tolerability profile and comparison with ibrutinib profile in B‐cell malignancies: Post hoc analysis of a large clinical trial safety database
Zanubrutinib safety/tolerability profile and comparison with ibrutinib profile in B‐cell malignancies: Post hoc analysis of a large clinical trial safety database Open
Introduction: Bruton tyrosine kinase inhibitors (BTKi) block B-cell receptor pathway signaling, leading to growth inhibition and cell death in malignant B-cells. First-generation BTKi, ibrutinib (ibr) revolutionized treatment; however, inh…
View article: A case of Hb Rothschild (<i>HBB</i>: c.112T>A) with low pulse oximetry: a first familial presentation in China
A case of Hb Rothschild (<i>HBB</i>: c.112T>A) with low pulse oximetry: a first familial presentation in China Open
A 37-year-old Chinese man complained of recurrent dyspnea, with low pulse oximetry (SpO2) and normal partial pressure of oxygen (PaO2) by blood gas analysis. The patient's P50 was elevated at 47.3 mmHg, while hemoglobin fraction by capilla…
View article: Radiosensitization by microRNA30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft*
Radiosensitization by microRNA30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft* Open
Objective We aimed to observe the radiosensitization effect of mir-30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft and to explore the underlying mechanism. Methods A549 cell lines with either stable upregulation or dow…
View article: Tanshinone IIA potentiates the efficacy of imatinib by regulating the AKT‑MDM2‑P53 signaling pathway in Philadelphia chromosome‑positive acute lymphoblastic leukemia
Tanshinone IIA potentiates the efficacy of imatinib by regulating the AKT‑MDM2‑P53 signaling pathway in Philadelphia chromosome‑positive acute lymphoblastic leukemia Open
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is triggered by breakpoint cluster region-abelson leukemia virus (BCR/ABL) kinase. Targeting BCR/ABL kinase with tyrosine kinase inhibitors combined with chemotherapy …
View article: Evaluation of endocrine therapy combined with intensity modulated radiation therapy in patients with advanced prostate cancer
Evaluation of endocrine therapy combined with intensity modulated radiation therapy in patients with advanced prostate cancer Open
Objective The aim of this study was to study the effect of endocrine therapy combined with intensity-modulated radiation therapy in patients with advanced prostate cancer. Methods The clinical data of 231 patients with advanced prostate ca…
View article: Management strategy for hematological malignancy patients with acute respiratory failure
Management strategy for hematological malignancy patients with acute respiratory failure Open
Acute respiratory failure (ARF) is still the major cause of intensive care unit (ICU) admission for hematological malignancy (HM) patients although the advance in hematology and supportive care has greatly improved the prognosis. Clinician…
View article: Life-threatening bleeding in a patient with pemphigoid-induced acquired hemophilia A and successfully treated with rituximab and rFVIIa
Life-threatening bleeding in a patient with pemphigoid-induced acquired hemophilia A and successfully treated with rituximab and rFVIIa Open
Rationale: Acquired hemophilia A (AHA) is a rare bleeding disorder with prolonged activated partial thromboplastin time (aPTT). Severe hemorrhage may occur, especially in refractory AHA. Patient concerns: We reported a 63-year-old man who …
View article: Advances in CD30- and PD-1-targeted therapies for relapsed or refractory Hodgkin lymphoma.
Advances in CD30- and PD-1-targeted therapies for relapsed or refractory Hodgkin lymphoma. Open
The current standard approach for relapsed or refractory (R/R) Hodgkin lymphoma (HL) is salvage chemotherapy, followed by autologous stem cell transplantation (ASCT). However, this therapeutic regimen is successful in only half of patients…
View article: Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis*
Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis* Open
Objective This study aimed to investigate the effects of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis in patients with esophageal cancer. Methods Seventy-five patients with esophageal cancer who met the e…
View article: Targeting CLL-1 for acute myeloid leukemia therapy
Targeting CLL-1 for acute myeloid leukemia therapy Open
Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing num…