Explanipedia

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies Open

Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan , et al. · 2025

Exploring Options for the Application of Azobenzene for Molecular Solar Thermal Energy Storage: Integration with Parabolic Trough Solar Systems Open

Zhang Li, Chuanyong Guo, Yazhu Zhang, Haofeng Wang, Wenjing Liu , et al. · 2025

Molecular solar thermal (MOST) energy systems can be utilized for the absorption, storage, and release of energy from the ultraviolet (UV) band of the solar spectrum. In this study, we designed a molecular solar thermal energy storage and …

Engineering and application of multiepitope recombinant proteins to enhance resistance to Botrytis cinerea in tomatoes: a new paradigm for creating plant immune activators Open

Xiaxia Man, You Huang, Zhiqiang Cheng, Junhao Li, D. Yao , et al. · 2025

Plant elicitors have emerged as key agents in effectively invoking immune responses across various plant species, gaining attention for their role in sustainable agricultural protection strategies. However, the economic utility of peptide …

Penalized weighted GEEs for high-dimensional longitudinal data with informative cluter size Open

Yue Ma, Haofeng Wang, Xuejun Jiang · 2025

High-dimensional longitudinal data have become increasingly prevalent in recent studies, and penalized generalized estimating equations (GEEs) are often used to model such data. However, the desirable properties of the GEE method can break…

Controllable Synthesis and Photothermal Properties of Differentially Substituted Azobenzene Materials Open

Li Zhang, Yuhao Zhang, Wenjing Liu, Yonglei Jin, Zhiyi Zhang , et al. · 2025

ECG signal analysis and detection system based on deep learning Open

Yingqi Liu, Chenyu Han, Zimu Li, Wei Luo, Xinrui Huang , et al. · 2024

In view of the problems of large workload and easy error in traditional manual recognition of ECG signals, and the existing ECG monitoring equipment still has few ECG signal recognition types, low diagnostic accuracy, and excessive relianc…

Decorrelated forward regression for high dimensional data analysis Open

Xuejun Jiang, Yue Ma, Haofeng Wang · 2024

Forward regression is a crucial methodology for automatically identifying important predictors from a large pool of potential covariates. In contexts with moderate predictor correlation, forward selection techniques can achieve screening c…

Simulation of Urban Growth Boundary under the Guidance of Stock Development: A Case Study of Wuhan City Open

Yang Zhang, Xiaojiang Xia, Jiandong Li, Luge Xing, Chengchao Yang , et al. · 2024

The implementation of an urban growth boundary (UGB) can effectively control urban sprawl and promote efficient land use, which is crucial for future urban development. However, most of existing studies overlook the reuse of existing idle …

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry Open

Haofeng Wang, Qi Yang, Xiaoce Liu, Zili Xu, Maolin Shao , et al. · 2023

Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases…

Model Selection for High Dimensional Nonparametric Additive Models via Ridge Estimation Open

Haofeng Wang, Hongxia Jin, Xuejun Jiang, Jingzhi Li · 2022

In ultrahigh dimensional data analysis, to keep computational performance well and good statistical properties still working, nonparametric additive models face increasing challenges. To overcome them, we introduce a methodology of model s…

Crystal structure of monkeypox H1 phosphatase, an antiviral drug target Open

Wen Cui, Haojun Huang, Yinkai Duan, Zhi Luo, Haofeng Wang , et al. · 2022

The current monkeypox outbreak has caused over 73,000 global cases, but the effective treatments are very limited. The dual specific phosphatase (H1) from monkeypox antagonizes the immune response and is crucial for viral replication, maki…

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target Open

Wen Cui, Haojun Huang, Yinkai Duan, Zhi Luo, Haofeng Wang , et al. · 2022

The current monkeypox outbreak has caused over 64,000 global cases, but the effective treatments are very limited. The dual specific phosphatase (H1) from monkeypox antagonizes the immune response and is crucial for viral replication, maki…

Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue Open

Haofeng Wang, Yunjie Xiao, Xia Chen, Mengwen Zhang, Guangxin Sun , et al. · 2022

Nonnested model selection based on empirical likelihood Open

Jiancheng Jiang, Jiang Xuejun, Haofeng Wang · 2022

We propose an empirical likelihood ratio test for nonparametric model selection, where the competing models may be nested, nonnested, overlapping, misspecified, or correctly specified. It compares the squared prediction errors of models ba…

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332 Open

Yao Zhao, Chao Fang, Qi Zhang, Ruxue Zhang, Xiangbo Zhao , et al. · 2021

Structural and mechanistic insights into the complexes formed by <i>Wolbachia</i> cytoplasmic incompatibility factors Open

Yunjie Xiao, Hongli Chen, Haofeng Wang, Mengwen Zhang, Xia Chen , et al. · 2021

Significance Mosquito-borne diseases cause more than 700,000 deaths annually. Wolbachia pipientis , an intracellular bacterium infecting many insect species, can manipulate host reproduction through cytoplasmic incompatibility (CI) and is …

Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex Open

Jiqin Wu, Haofeng Wang, Qiaojie Liu, Rui Li, Yan Gao , et al. · 2021

Remdesivir (RDV), a nucleotide analog with broad-spectrum features, has exhibited effectiveness in COVID-19 treatment. However, the precise working mechanism of RDV when targeting the viral RNA-dependent RNA polymerase (RdRP) has not been …

Intervention Effect of Total Glucoside of Paeony on Mesangial Proliferative Glomerulonephritis in Rats Open

Xiujun Yao, Haofeng Wang, Zhang Ligong, Jingzhang Wu, Lijun Wang · 2020

Total glucosides of paeony (TGP), Mesangial proliferative glomerulonephritis (MsPGN), Rats, TGF-β1, CTGFTen out of 30 rats were randomly selected as normal group.Remaining 20 rats were used to establish rat model of mesangial proliferative…

The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2 Open

Zhenming Jin, Haofeng Wang, Yinkai Duan, Haitao Yang · 2020

Architecture of a SARS-CoV-2 mini replication and transcription complex Open

Liming Yan, Ying Zhang, Ji Ge, Litao Zheng, Gao Yan , et al. · 2020

Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic structure of a SARS-CoV-2 mini RTC, assembled by viral RNA-dep…

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis Open

Liming Yan, Ji Ge, Litao Zheng, Ying Zhang, Gao Yan , et al. · 2020

Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase Open

Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu , et al. · 2020

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur Open

Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang , et al. · 2020

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease Open

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li , et al. · 2020

Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments. A promising drug target is the…

Structure of the RNA-dependent RNA polymerase from COVID-19 virus Open

Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao , et al. · 2020

The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al. focused on a complex that plays a key role in…

Technical education and reshaping criminals Open

Haofeng Wang · 2019

Repeated abortion in adulthood induces cognition impairment in aged mice Open

Lili Wang, Ying Zhang, Haofeng Wang, Hui Li, Ziying Zhao , et al. · 2018

Age-related cognitive decline is one of the major aspects that impede successful aging in humans. Repeated abortion in adulthood can accelerate or aggravate cognitive deficiency during aging. Here we used repeated abortion in female mice a…

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH Open

Han Zhou, Fenghua Wang, Haofeng Wang, Cheng Chen, Tianqing Zhang , et al. · 2017

An outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly potentially associated with ZIKV infection has already caused a public health emergency of international con…

Imbalance in Spatial Accessibility to Primary and Secondary Schools in China: Guidance for Education Sustainability Open

Yuan Gao, Qingsong He, Yaolin Liu, Lingyu Zhang, Haofeng Wang , et al. · 2016

Compulsory education is an important aspect of the societal development. Meanwhile, education equality safeguards the effectiveness of education systems and is an important part of social equality. This study analyzes the inequality of com…

Recent progress in the discovery of inhibitors targeting coronavirus proteases Open

Haofeng Wang, Song Xue, Haitao Yang, Cheng Chen · 2016

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