Haohao Dong
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View article: New Periodontal Regeneration Material For Hydrogel Stents
New Periodontal Regeneration Material For Hydrogel Stents Open
Aim or purpose: Periodontal bone grafting makes use bone graft materials to promote new bone formation and regeneration. This study focuses on the preparation and evaluation of novel composite hydrogel scaffolds with the aim to promote per…
View article: Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant Open
Mucosal immunity provides efficient protection against upper-airway infections, limiting viral shedding and transmission. However, currently, no nasal spray COVID-19 vaccines are approved by WHO for global use. Here we develop a two-compon…
View article: Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori (H. pylori) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genotyp…
View article: <i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
<i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori ( H. pylori ) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genot…
View article: A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants Open
The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts of immune imprinting, stemming from continuous exp…
View article: Enhancing Spatial Allocation of Pediatric Medical Facilities for Reduced Travel-Related CO2 Emissions: A Case Study in Tianjin, China
Enhancing Spatial Allocation of Pediatric Medical Facilities for Reduced Travel-Related CO2 Emissions: A Case Study in Tianjin, China Open
Due to the limited availability of medical facilities and the urgency and irreplaceability of medical-seeking behaviors, the transportation processes used to access these resources inherently result in high carbon emissions. Unfortunately,…
View article: Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE Open
Outer membrane (OM) lipoproteins serve vital roles in Gram-negative bacteria, contributing to their pathogenicity and drug resistance. For these lipoproteins to function, they must be transported from the inner membrane (IM), where they ar…
View article: The revelation of high-yield amino acids and probiotic characteristics of an intestinal Lacticaseibacillus rhamnosus X9C17
The revelation of high-yield amino acids and probiotic characteristics of an intestinal Lacticaseibacillus rhamnosus X9C17 Open
With the popularization of probiotic products, tapping high-quality probiotics is crucial. Therefore, in this study, Lacticaseibacillus rhamnosus (X9C17) was selected from a pool of 54 isolates for its remarkable ability to survive in simu…
View article: Structural insights into the mechanotransducing mechanism of FtsEX in cell division
Structural insights into the mechanotransducing mechanism of FtsEX in cell division Open
The filamentous temperature‐sensitive (Fts) protein FtsEX plays a pivotal role in Escherichia coli ( E. coli ) cell division by facilitating the activation of peptidoglycan hydrolysis through the adaptor EnvC. FtsEX belongs to the type VII…
View article: Structural basis of circularly permuted group II intron self-splicing
Structural basis of circularly permuted group II intron self-splicing Open
The group II introns are self-splicing ribozymes intervened between two exons that undergo excision and exon ligation through lariat formation, which are considered as ancestral forms of spliceosomes. Circularly permuted (CP) group II intr…
View article: SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease
SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease Open
Soluble host factors in the upper respiratory tract can serve as the first line of defense against SARS-CoV-2 infection. In this study, we described the identification and function of a human airway trypsin-like protease (HAT), capable of …
View article: miR-Cabiner: A universal microRNA sensing platform based on self- stacking cascaded bicyclic DNA circuit-mediated CRISPR/Cas12a
miR-Cabiner: A universal microRNA sensing platform based on self- stacking cascaded bicyclic DNA circuit-mediated CRISPR/Cas12a Open
Background CRISPR/Cas12a-based diagnostics enable great potential in the sensing nucleic acid, but its application was limited by the sequence dependence. Results A platform termed miR-Cabiner (a universal miRNA sensing platform based on s…
View article: Nanoplatform Based Intranasal Vaccines: Current Progress and Clinical Challenges
Nanoplatform Based Intranasal Vaccines: Current Progress and Clinical Challenges Open
Multiple vaccine platforms have been employed to develop the nasal SARS-CoV-2 vaccines in preclinical studies, and the dominating pipelines are viral vectored as protein-based vaccines. Among them, several viral vectored-based vaccines hav…
View article: XBB.1.16‐RBD‐based trimeric protein vaccine can effectively inhibit XBB.1.16‐included XBB subvariant infection
XBB.1.16‐RBD‐based trimeric protein vaccine can effectively inhibit XBB.1.16‐included XBB subvariant infection Open
The newly identified XBB.1.16‐containing sublineages, including XBB.1.5, have become the prevailing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variant in circulation. Unlike previous Omicron XBB variants (e.g., XBB.1.5 an…
View article: Structure and activity of the septal peptidoglycan hydrolysis machinery crucial for bacterial cell division
Structure and activity of the septal peptidoglycan hydrolysis machinery crucial for bacterial cell division Open
The peptidoglycan (PG) layer is a critical component of the bacterial cell wall and serves as an important target for antibiotics in both gram-negative and gram-positive bacteria. The hydrolysis of septal PG (sPG) is a crucial step of bact…
View article: A chimeric adenovirus‐vectored vaccine based on Beta spike and Delta RBD confers a broad‐spectrum neutralization against Omicron‐included SARS‐CoV‐2 variants
A chimeric adenovirus‐vectored vaccine based on Beta spike and Delta RBD confers a broad‐spectrum neutralization against Omicron‐included SARS‐CoV‐2 variants Open
Urgent research into innovative severe acute respiratory coronavirus‐2 (SARS‐CoV‐2) vaccines that may successfully prevent various emerging emerged variants, particularly the Omicron variant and its subvariants, is necessary. Here, we desi…
View article: Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization
Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization Open
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility and profound immune-escape capacity makes it an urgent need to develop broad-spectrum therapeutics. Nanobodie…
View article: Dynamic topology-mediated maturation of β-barrel proteins in BAM-catalyzed folding
Dynamic topology-mediated maturation of β-barrel proteins in BAM-catalyzed folding Open
BamA is an essential component of the β-barrel assembly complex (BAM) that catalyzes the insertion and assembly of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. BamA adopts two distinct conformations: the inward-open a…
View article: Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses
Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses Open
Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is able to infect humans. ALSV has a multi-segmented genome organization and is evolutionarily distant from canonical mono-segmented flaviviruses. The v…
View article: Cryo-EM structures of human GPR34 enable the identification of selective antagonists
Cryo-EM structures of human GPR34 enable the identification of selective antagonists Open
GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a cryo-electron microscopy (cryo-EM) structure of GPR34 bound…
View article: Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM
Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM Open
Gram-negative bacteria contain an asymmetric outer membrane, in which the outer leaflet is composed of lipopolysaccharide (LPS). LPS, a drug target of polymyxin, plays an essential role in drug resistance, biofilm formation, and pathogenes…