Hongqian Guo
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View article: Supplementary Data from Cancer-Associated Fibroblast–Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance
Supplementary Data from Cancer-Associated Fibroblast–Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance Open
Supplementary Data
View article: SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1
SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1 Open
Metastasis is the hallmark of lethal renal cell carcinoma (RCC), and the underlying mechanism driving RCC metastasis remains insufficiently understood. Amino acid metabolism remodeling plays a key role in the matastasis of RCC. In this stu…
View article: TFE3 fusion proteins promoted the progression of Xp11.2 translocation renal cell carcinoma through post-translational modification of PDL1 by upregulating CCND1/Cyclin D1
TFE3 fusion proteins promoted the progression of Xp11.2 translocation renal cell carcinoma through post-translational modification of PDL1 by upregulating CCND1/Cyclin D1 Open
Not applicable.
View article: The early therapeutic efficacy of robot-assisted laparoscopic radical prostatectomy with combined anterior and posterior approach: a cohort study
The early therapeutic efficacy of robot-assisted laparoscopic radical prostatectomy with combined anterior and posterior approach: a cohort study Open
This study aims to compare the perioperative outcomes, postoperative urinary control rates, and positive surgical margin (PSM) rates of robot-assisted laparoscopic radical prostatectomy using a combined anterior and posterior approach (AP-…
View article: The expression of prostate-specific membrane antigen in intraductal carcinoma of the prostate
The expression of prostate-specific membrane antigen in intraductal carcinoma of the prostate Open
View article: E3-Rewrite: Learning to Rewrite SQL for Executability, Equivalence,and Efficiency
E3-Rewrite: Learning to Rewrite SQL for Executability, Equivalence,and Efficiency Open
SQL query rewriting aims to reformulate a query into a more efficient form while preserving equivalence. Most existing methods rely on predefined rewrite rules. However, such rule-based approaches face fundamental limitations: (1) fixed ru…
View article: A randomized study of apalutamide in Chinese patients with non-metastatic castration-resistant prostate cancer
A randomized study of apalutamide in Chinese patients with non-metastatic castration-resistant prostate cancer Open
View article: Trend in testicular volume change after orchiopexy in 854 children with cryptorchidism
Trend in testicular volume change after orchiopexy in 854 children with cryptorchidism Open
The aim of this study was to investigate the trend in testicular volume changes after orchiopexy in children with cryptorchidism. The clinical data of 854 children with cryptorchidism who underwent orchiopexy between January 2013 and Decem…
View article: RETRACTED: Prognostic Impact of Surgical Intervention in Clear Cell Renal Cell Carcinoma: A SEER Database Analysis with Development and Validation of a Nomogram for Surgical Patients
RETRACTED: Prognostic Impact of Surgical Intervention in Clear Cell Renal Cell Carcinoma: A SEER Database Analysis with Development and Validation of a Nomogram for Surgical Patients Open
The authors have requested that this preprint be removed from Research Square.
View article: Development and validation of a nomogram for predicting postoperative recurrent lumbar disc herniation after unilateral biportal endoscopic discectomy
Development and validation of a nomogram for predicting postoperative recurrent lumbar disc herniation after unilateral biportal endoscopic discectomy Open
Background No study has investigated the incidence or risk factors of recurrent lumbar disc herniation (rLDH) after unilateral biportal endoscopic discectomy (UBED) in patients with lumbar disc herniation. Therefore, we aimed to construct …
View article: The <scp>N6</scp>‐methyladenosine reader <scp>IGF2BP3</scp> promotes bladder cancer progression through enhancing <scp>HSP90AB1</scp> expression
The <span>N6</span>‐methyladenosine reader <span>IGF2BP3</span> promotes bladder cancer progression through enhancing <span>HSP90AB1</span> expression Open
N 6 ‐methyladenosine (m 6 A) is the most abundant RNA modification in mammalian cells, and has emerged as an important player in tumour development through post‐transcriptional gene regulation. In this study, we found that the m 6 A reader…
View article: Plasma <scp>tsRNA</scp> Signatures Serve as a Novel Biomarker for Bladder Cancer
Plasma <span>tsRNA</span> Signatures Serve as a Novel Biomarker for Bladder Cancer Open
Bladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non‐invasive diagnostic modalities are insuffici…
View article: Efficacy and safety of <scp>JMT103</scp> in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial
Efficacy and safety of <span>JMT103</span> in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial Open
This study aimed to assess the efficacy and safety of three dosing regimens of JMT103 in patients with bone metastases from solid tumors. Eligible patients were randomly assigned to receive JMT103 subcutaneously, 120 mg every 4 weeks (Coho…
View article: Pathologic characteristics and management strategies for two categories of prostate cancer patients with low prostate-specific antigen undergoing radical prostatectomy
Pathologic characteristics and management strategies for two categories of prostate cancer patients with low prostate-specific antigen undergoing radical prostatectomy Open
Predicting low PSA PCa remains challenging, but mpMRI and PSAD could be valuable predictors. Both low PSA groups showed a likelihood of clinical significance, with favorable pathological features. Early diagnosis and treatment are crucial,…
View article: Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study
Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study Open
View article: Single-Cell Multiomics Identifies Glycan Epitope LacNAc as a Potential Cell-Surface Effector Marker of Peripheral T Cells in Bladder Cancer Patients
Single-Cell Multiomics Identifies Glycan Epitope LacNAc as a Potential Cell-Surface Effector Marker of Peripheral T Cells in Bladder Cancer Patients Open
Cancer is a systemic disease continuously monitored and responded to by the human global immune system. Peripheral blood immune cells, integral to this surveillance, exhibit variable phenotypes during tumor progression. Glycosylation, as o…
View article: Tumor-associated macrophages in bladder cancer: roles and targeted therapeutic strategies
Tumor-associated macrophages in bladder cancer: roles and targeted therapeutic strategies Open
Bladder cancer (BC) is the ninth most common and “expensive” cancer in the world. Despite the availability of various treatment modalities such as chemotherapy, immunotherapy and surgery, the overall survival rate of patients with advanced…
View article: Clinical application and efficacy analysis of robot-assisted laparoscopic tumor enucleation combined with tumor aspiration in the treatment of renal hilar angiomyolipoma
Clinical application and efficacy analysis of robot-assisted laparoscopic tumor enucleation combined with tumor aspiration in the treatment of renal hilar angiomyolipoma Open
View article: Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance Open
Cancer stem-like cells (CSCs) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microen…
View article: Supplementary Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
Supplementary Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance Open
Supplementary Data
View article: Supplementary Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
Supplementary Data from Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance Open
Supplementary Data
View article: A novel pelvis-prostate model BPPP predicts immediate urinary continence after Retzius-sparing robotic-assisted laparoscopic radical prostatectomy
A novel pelvis-prostate model BPPP predicts immediate urinary continence after Retzius-sparing robotic-assisted laparoscopic radical prostatectomy Open
View article: Targeted gene sequencing reveals disparate genomic mutations between young and older adults in renal cell carcinoma
Targeted gene sequencing reveals disparate genomic mutations between young and older adults in renal cell carcinoma Open
Our findings reveal previously unrecognized associations between age and the molecular underpinnings of RCC. These associations may serve as valuable insights to guide precision diagnostics and treatments for RCC.
View article: Diagnostic performance of magnetic resonance imaging features to differentiate adrenal pheochromocytoma from adrenal tumors with positive biochemical testing results
Diagnostic performance of magnetic resonance imaging features to differentiate adrenal pheochromocytoma from adrenal tumors with positive biochemical testing results Open
Background It is extremely essential to accurately differentiate pheochromocytoma from Adrenal incidentalomas (AIs) before operation, especially biochemical tests were inconclusive. We aimed to evaluate the value of magnetic resonance imag…
View article: Follow-up on Patients with Initial Negative mpMRI Target and Systematic Biopsy for PI-RADS ≥3 Lesions – An EAU-YAU Study Enhancing Prostate Cancer Detection.
Follow-up on Patients with Initial Negative mpMRI Target and Systematic Biopsy for PI-RADS ≥3 Lesions – An EAU-YAU Study Enhancing Prostate Cancer Detection. Open
Purpose To investigate the detection and predictors of prostate cancer (PCA) and clinically significant prostate cancer (csPCA) in patients with positive multiparametric MRI (mpMRI) followed by a negative MRI – guided target biopsy (TB) an…
View article: BPPP: A novel pelvis-prostate model predicting immediate urinary continence after Retzius-sparing robotic-assisted laparoscopic radical prostatectomy
BPPP: A novel pelvis-prostate model predicting immediate urinary continence after Retzius-sparing robotic-assisted laparoscopic radical prostatectomy Open
This study aimed to construct a novel pelvis-prostate model BPPP which consists of body mass index (BMI), prostate volume (PV), pelvic cavity index (PCI) and prostate-muscle index (PMI) to predict the immediate urinary continence after Ret…
View article: Performance of 18F-FDG PET/MRI and its parameters in staging and neoadjuvant therapy response evaluation in bladder cancer
Performance of 18F-FDG PET/MRI and its parameters in staging and neoadjuvant therapy response evaluation in bladder cancer Open
View article: Modified Retzius-sparing robot-assisted radical prostatectomy for cases with anterior tumor: a propensity score-matched analysis
Modified Retzius-sparing robot-assisted radical prostatectomy for cases with anterior tumor: a propensity score-matched analysis Open
Objective To compare the outcomes between a modified Retzius-sparing robot-assisted radical prostatectomy (mRS-RARP) technique and conventional robot-assisted radical prostatectomy (Con-RARP) technique for cases with anterior prostate canc…
View article: Targeted gene sequencing reveals disparate genomic mutations between young and older adults in Renal Cell Carcinoma
Targeted gene sequencing reveals disparate genomic mutations between young and older adults in Renal Cell Carcinoma Open
Background Renal cell carcinoma (RCC) is a type of cancer that can develop at any point in adulthood, spanning the range of age-related changes that occur in the body. However, the specific molecular mechanisms underlying the connections b…
View article: Multi-cohort validation of Ascore: an anoikis-based prognostic signature for predicting disease progression and immunotherapy response in bladder cancer
Multi-cohort validation of Ascore: an anoikis-based prognostic signature for predicting disease progression and immunotherapy response in bladder cancer Open