Explanipedia

The impact of marital status on hypertension: SEM analysis of a Chinese general population cohort Open

Yajiao Fan, Huijing He, Haojun Li, Zhili Chen, Chang Liu , et al. · 2025

Results confirm a close association between marital status and hypertension in women, with factors like age and economic status potentially influencing this relationship. This underscores the need for further research to explore the intric…

Generative Artificial Intelligence Supported Programming Learning: Learning Effectiveness and Core Competence Open

Haojun Li, Qing Huang, Liangjian Wen, Wei Chen, Xu Zhang · 2025

The programming curriculum is crucial in today’s digital age, but a common issue is its focus on technical training while neglecting essential skills enhancement. Teachers lack structured and practical guidance on instructional methods, an…

Comparison of recurrence patterns between patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and postoperative adjuvant chemoradiotherapy Open

Kunhan Ni, Yixuan Huang, Simiao Lu, Longlin Jiang, Huan Zhang , et al. · 2025

Purpose To compare the recurrence patterns and survival outcomes between patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and adjuvant chemoradiotherapy (ACRT). Methods We retrospect…

Collaborative Learning Groupings Incorporating Deep Knowledge Tracing Optimization Strategies Open

Haojun Li, Yaohan Chen, Wei‐Chih Liao, Xuhui Wang · 2025

Effective grouping in collaborative learning is crucial for enhancing the efficiency of collaborative learning. A well-structured collaborative learning group can significantly enhance the learning effectiveness of both individuals and gro…

A preoperative pathological staging prediction model for esophageal cancer based on CT radiomics Open

Haojun Li, Shuo Liang, Mengxuan Cui, Weiqiu Jin, Xiaofeng Jiang , et al. · 2025

This study established a non-invasive preoperative radiomics model that demonstrated good predictive performance in determining the pTNM staging, pT staging, vascular invasion, and perineural invasion for EC patients. These results could i…

Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula Open

Teng Chen, Wenbo Liu, S. J. Zhu, Abudula Aji, Chen Zhang , et al. · 2024

Persistent pain frequently precipitates the development of anxiety disorders, yet the underlying mechanisms are not fully understood. In this study, we employed a mouse model that simulates trigeminal neuralgia and observed a marked reduct…

Author Correction: Community assessment of methods to deconvolve cellular composition from bulk gene expression Open

Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew Lamb , et al. · 2024

Comparative analysis of manual vs. mechanical suturing techniques in esophagectomy: A propensity score‑matched study of long‑term outcomes Open

Simiao Lu, Kexun Li, Longlin Jiang, Jicheng Xiong, Shuo Liang , et al. · 2024

Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a major health concern worldwide, particularly in China. Surgical resection is still considered the primary curative treatment for this disease. However, the eff…

Community assessment of methods to deconvolve cellular composition from bulk gene expression Open

Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew Lamb , et al. · 2024

We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using in vitro and i…

The Impact of Marital Status on Hypertension: SEM Analysis of a Chinese General Population Cohort Open

Yajiao Fan, Huijing He, Haojun Li, Zhili Chen, Chang Liu , et al. · 2024

Background Hypertension, a chronic non-communicable disease, has multifaceted and complex etiologies influenced by various risk factors. This study examines the role of marital status among the factors influencing blood pressure levels and…

The combination of transcriptome and Mendelian randomization reveals clinical and immuno-functional biomarkers of alternative splicing regulation associated with planar cell polarity signaling pathways in pan-cancer Open

Haojun Li, Jian Xu, Qinlan Li, Guoqiang Xu, Yanjun Liang , et al. · 2024

Background The intricate interplay between alternative splicing (AS) events and the planar cell polarity (PCP) signaling pathway is known to play a crucial role in cancer initiation and progression. Understanding the prognostic implication…

Clinical value of folate receptor-positive circulating tumor cells in patients with esophageal squamous cell carcinomas: a retrospective study Open

Qiang Zhou, Qiao He, Wenwu He, Chenghao Wang, Guangyuan Liu , et al. · 2023

Background The aim of the study is to explore the role of preoperative folate receptor-positive circulating tumor cell (FR + CTC) levels in predicting disease-free survival (DFS) and overall survival (OS) in patients with esophageal squamo…

Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda Open

Robert Zupko, Tran Dang Nguyen, Jean Claude Semuto Ngabonziza, Michee Kabera, Haojun Li , et al. · 2023

Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated Plasmodium falciparum malaria, but the emergence of the new pfkelch13 R561H mutation in Rwanda, associated with delayed parasite clearance, suggests th…

Long-term survival of esophageal squamous cell carcinoma after surgical treatment in a large-scale retrospective study from a single cancer center Open

Kunhan Ni, Zhiyu Li, Kexun Li, Changding Li, Kunyi Du , et al. · 2023

Purpose To analyze the long-term overall survival (OS) and influencing factors of patients with esophageal squamous cell cancer (ESCC) under surgical treatment. Method We collected patients with ESCC who received surgical treatment in Sich…

A Review Investigating Women’s Marital Freedom and Reproductive Freedom Open

Haojun Li · 2023

In China, in many social situations, there is implicit discrimination against women. In a narrow sense, from the perspective of young people's entertainment projects, many bars have the phenomenon of "cutting cabbage", which means "boys ge…

Resected lymph nodes and survival of patients with esophageal squamous cell carcinoma: an observational study Open

Kexun Li, Xuefeng Leng, Wenwu He, Kunyi Du, Changding Li , et al. · 2023

Increasing the number of LNs harvested during surgery to 24 or more could improve the OS of patients with positive LNs but not that of patients with negative LNs.

Impact of two‑field or three‑field lymphadenectomy on overall survival in middle and lower thoracic esophageal squamous cell carcinoma: A single‑center retrospective analysis Open

Kexun Li, Kunyi Du, Kun Liu, Xin Nie, Changding Li , et al. · 2023

Squamous cell carcinoma is the main subtype of esophageal cancer in East Asia. The effect of the number of lymph nodes (LNs) removed to treat middle and lower thoracic esophageal squamous cell carcinoma (ESCC) in China remains controversia…

The efficacy and safety of neoadjuvant immunotherapy in resectable locally advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis Open

Wenwu He, Chenghao Wang, Changding Li, Xin Nie, Haojun Li , et al. · 2023

Objective This systematic review and meta-analysis aimed to explore the efficacy and safety of neoadjuvant immunotherapy in patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC). Background Several studies hav…

Potential policy interventions for slowing the spread of artemisinin-resistant<i>pfkelch</i>R561H mutations in Rwanda Open

Robert Zupko, Tran Dang Nguyen, Jean Claude Semuto Ngabonziza, Michee Kabera, Haojun Li , et al. · 2022

Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated Plasmodium falciparum malaria. However, the emergence of a novel pfkelch13 R561H mutation in Rwanda, with associated delayed parasite clearance, sugges…

Corrigendum: Risk factors of falls in elderly patients with visual impairment Open

Shuyi Ouyang, Chunwen Zheng, Zhanjie Lin, Xiaoni Zhang, Haojun Li , et al. · 2022

[This corrects the article DOI: 10.3389/fpubh.2022.984199.].

The Role of Dietary Patterns and Dietary Quality on Body Composition of Adolescents in Chinese College Open

Hongrui Li, Dajun Li, Xianyun Wang, Huini Ding, Qinghua Wu , et al. · 2022

There is limited evidence regarding the effects of dietary pattern and dietary quality on the risk of unhealthy weight status and related body composition in Chinese adolescence. In particular, studies using bioelectrical impedance analyze…

365. PROGNOSTIC COMPARISON OF LYMPHOVASCULAR INVASION AND LYMPH NODE METASTASIS IN ESOPHAGEAL CANCER PATIENTS Open

Kexun Li, Xue Feng Leng, Xin Nie, Kun Liu, Wenwu He , et al. · 2022

The incidence and mortality of esophageal cancer are high-ranking in the world, more than half of cases occur in China. The cornerstone of treatment for resectable esophageal cancer is esophagectomy. Lymphovascular invasion and lymph node …

Risk factors of falls in elderly patients with visual impairment Open

Shuyi Ouyang, Chunwen Zheng, Zhanjie Lin, Xiaoni Zhang, Haojun Li , et al. · 2022

Objective To examine the risk factors for falls in elderly patients with visual impairment (VI) and assess the predictive performance of these factors. Methods Between January 2019 and March 2021, a total of 251 elderly patients aged 65–92…

Neural Generation Meets Real People: Building a Social, Informative Open-Domain Dialogue Agent Open

Ethan A. Chi, Ashwin Paranjape, Abigail See, Caleb Chiam, Kathleen Kenealy , et al. · 2022

We present Chirpy Cardinal, an open-domain social chatbot. Aiming to be both informative and conversational, our bot chats with users in an authentic, emotionally intelligent way. By integrating controlled neural generation with scaffolded…

Community assessment of methods to deconvolve cellular composition from bulk gene expression Open

Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew Lamb , et al. · 2022

We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using in vitro and i…

Tislelizumab Plus Chemotherapy Sequential Neoadjuvant Therapy for Non-cCR Patients After Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma (ETNT): An Exploratory Study Open

Wenwu He, Chenghao Wang, Lei Wu, Gang Wan, Baisen Li , et al. · 2022

Background Esophageal squamous cell carcinoma (ESCC) remains a challenging malignant tumor with poor prognosis and limited treatment methods worldwide, and most patients are at a locally advanced stage at diagnosis. High recurrence and met…

Neural Generation Meets Real People: Building a Social, Informative Open-Domain Dialogue Agent Open

A. Ethan, Ashwin Paranjape, Abigail See, Caleb Chiam, Trenton Chang , et al. · 2022

Ethan A. Chi, Ashwin Paranjape, Abigail See, Caleb Chiam, Trenton Chang, Kathleen Kenealy, Swee Kiat Lim, Amelia Hardy, Chetanya Rastogi, Haojun Li, Alexander Iyabor, Yutong He, Hari Sowrirajan, Peng Qi, Kaushik Ram Sadagopan, Nguyet Minh …

Multimodal Reward Shaping for Efficient Exploration in Reinforcement Learning Open

Mingqi Yuan, Mon-On Pun, Yi Chen, Dong Wang, Haojun Li · 2021

Maintaining the long-term exploration capability of the agent remains one of the critical challenges in deep reinforcement learning. A representative solution is to leverage reward shaping to provide intrinsic rewards for the agent to enco…

A preliminary study identifies early postoperative lung volume changes in patients with non‑small cell lung cancer following video‑assisted thoracic surgery using CT volumetry Open

Xiaojun Du, Haojun Li, Langbo Liu, Min Zhang, Zhongben Tang , et al. · 2021

The present study aimed to investigate the changes in early postoperative lung volume in patients with non-small cell lung cancer (NSCLC) following video-assisted thoracic surgery (VATS) and to analyze the effects of the clinical character…

Large-Scale Quantitative Evaluation of Dialogue Agents’ Response Strategies against Offensive Users Open

Haojun Li, Dilara Soylu, Christopher D. Manning · 2021

As voice assistants and dialogue agents grow in popularity, so does the abuse they receive. We conducted a large-scale quantitative evaluation of the effectiveness of 4 response types (avoidance, why, empathetic, and counter), and 2 additi…

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