Hongming Pan
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View article: Analysis of common treatment-related adverse events of donafenib and its correlation with efficacy: exploratory analysis of the ZGDH3 study
Analysis of common treatment-related adverse events of donafenib and its correlation with efficacy: exploratory analysis of the ZGDH3 study Open
NCT02645981.
View article: AwareCompiler: Agentic Context-Aware Compiler Optimization via a Synergistic Knowledge-Data Driven Framework
AwareCompiler: Agentic Context-Aware Compiler Optimization via a Synergistic Knowledge-Data Driven Framework Open
Compiler optimization is crucial for enhancing program performance by transforming the sequence of optimization passes while maintaining correctness. Despite the promising potential of large language models (LLMs)-based agent for software …
View article: Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study
Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study Open
PURPOSE The phase III randomized open-label LEAP-015 study (ClinicalTrials.gov identifier: NCT04662710 ) evaluated first-line lenvatinib plus pembrolizumab and chemotherapy versus chemotherapy for advanced metastatic gastroesophageal adeno…
View article: Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial
Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial Open
After the global approval of atezolizumab plus bevacizumab and chemotherapy as first-line metastatic nonsquamous non-small-cell lung cancer (nsqNSCLC) treatment, the IMpower151 ( NCT04194203 ) trial was conducted in China to address region…
View article: Electronic Information Image Processing Based on Convolutional Neural Networks
Electronic Information Image Processing Based on Convolutional Neural Networks Open
In order to improve the accuracy and efficiency of mechanical part recognition, the author proposes a research on electronic information image processing based on convolutional neural networks. The author first performs saturation based gr…
View article: Pharmacokinetics of infigratinib and its active metabolites in Chinese patients with advanced gastric cancer harboring <i>FGFR2</i> gene amplification
Pharmacokinetics of infigratinib and its active metabolites in Chinese patients with advanced gastric cancer harboring <i>FGFR2</i> gene amplification Open
Infigratinib, an FGFR1‐3 selective oral tyrosine kinase inhibitor, has shown clinical activity in cancers with FGFR alterations. The pharmacokinetics (PK) of infigratinib and its major metabolites have been characterized in global populati…
View article: Efficacy and safety of dual blockade of HER2 and PD-1 in patients with HER2-positive gastric cancer: a retrospective, multicentre study
Efficacy and safety of dual blockade of HER2 and PD-1 in patients with HER2-positive gastric cancer: a retrospective, multicentre study Open
Human epidermal growth factor receptor 2 (HER2) expression is one of the most important pathological characteristics of gastric cancer. The positive rate of HER2 expression in patients with gastric cancer is approximately 20%. The phase II…
View article: Changing ALK-TKI mechanisms of resistance in re-biopsies of ALK-rearranged NSCLC: ALK mutations followed by SCLC-like histologic transformation: A case report
Changing ALK-TKI mechanisms of resistance in re-biopsies of ALK-rearranged NSCLC: ALK mutations followed by SCLC-like histologic transformation: A case report Open
Anaplastic lymphoma kinase (ALK) inhibitors are the recommended treatment of ALK-rearranged non-small cell lung cancer but are prone to eventual drug resistance. Herein we report a 45-year-old Asian woman diagnosed with EML4-ALK rearranged…
View article: SAFFRON-103: A Phase Ib Study of Sitravatinib Plus Tislelizumab in Anti-PD-(L)1 Refractory/Resistant Advanced Melanoma
SAFFRON-103: A Phase Ib Study of Sitravatinib Plus Tislelizumab in Anti-PD-(L)1 Refractory/Resistant Advanced Melanoma Open
Aim: Investigate TKI sitravatinib plus anti-PD-1 antibody tislelizumab in patients with unresectable/advanced/metastatic melanoma with disease progression on/after prior first-line anti-PD-(L)1 monotherapy. Methods: Open-label, multicenter…
View article: Exploring the Role of Preoperative Systemic Therapy and Primary Resection in NSCLC With Extrathoracic Metastases: Identifying the Optimal Candidates
Exploring the Role of Preoperative Systemic Therapy and Primary Resection in NSCLC With Extrathoracic Metastases: Identifying the Optimal Candidates Open
Background In non-small cell lung cancer (NSCLC), patients with extrathoracic metastases typically have a poor prognosis, with systemic chemotherapy being the standard care. The full potential of primary resection therapy (PRT) in these pa…
View article: Efficacy and safety of PD‑1 inhibitor plus antiangiogenic treatment in patients with unresectable biliary tract cancer: A multicenter retrospective study
Efficacy and safety of PD‑1 inhibitor plus antiangiogenic treatment in patients with unresectable biliary tract cancer: A multicenter retrospective study Open
Immunotherapy and antiangiogenic therapy have shown promising clinical activity in patients with advanced biliary tract cancer (BTC) in clinical trials. As the combination of these two treatments for BTC is not well studied in the real wor…
View article: Deep-Learning-Based Automated Identification and Visualization of Oral Cancer in Optical Coherence Tomography Images
Deep-Learning-Based Automated Identification and Visualization of Oral Cancer in Optical Coherence Tomography Images Open
Early detection and diagnosis of oral cancer are critical for a better prognosis, but accurate and automatic identification is difficult using the available technologies. Optical coherence tomography (OCT) can be used as diagnostic aid due…
View article: Association between frailty and the risk of all-cause and cause-specific mortality among cancer patients
Association between frailty and the risk of all-cause and cause-specific mortality among cancer patients Open
Background Cancer patients are vulnerable to frailty. While few studies have focused on its association with the mortality risk among cancer patients, the current study aims to reveal this association. Methods In this cohort study, 4723 ca…
View article: NLRP3 and Gut Microbiota Homeostasis: Progress in Research
NLRP3 and Gut Microbiota Homeostasis: Progress in Research Open
The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome…
View article: Corrigendum: Controlling nutritional status (CONUT) predicts survival in gastric cancer patients with immune checkpoint inhibitor (PD-1/PD-L1) outcomes
Corrigendum: Controlling nutritional status (CONUT) predicts survival in gastric cancer patients with immune checkpoint inhibitor (PD-1/PD-L1) outcomes Open
[This corrects the article DOI: 10.3389/fphar.2022.836958.].
View article: Comprehensive Analysis of Genomic Alterations in Hepatoid Adenocarcinoma of the Stomach and Identification of Clinically Actionable Alterations
Comprehensive Analysis of Genomic Alterations in Hepatoid Adenocarcinoma of the Stomach and Identification of Clinically Actionable Alterations Open
Hepatoid adenocarcinoma of the stomach (HAS) is a rare malignancy with aggressive biological behavior. This study aimed to compare the genetic landscape of HAS with liver hepatocellular carcinoma (LIHC), gastric cancer (GC), and AFP-produc…
View article: Safety and efficacy of Pucotenlimab (HX008) - a Humanized Immunoglobulin G4 Monoclonal Antibody in patients with locally advanced or metastatic melanoma: a single-arm, multicenter, phase II study
Safety and efficacy of Pucotenlimab (HX008) - a Humanized Immunoglobulin G4 Monoclonal Antibody in patients with locally advanced or metastatic melanoma: a single-arm, multicenter, phase II study Open
Background: Pucotenlimab is a novel recombinant humanized anti-PD-1 (Programmed death-1) monoclonal antibody, which belongs to the human IgG4/kappa subtype, and can selectively block the binding of PD-1 with its ligands PD-L1 and PD-L2. Me…
View article: STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet Cells
STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet Cells Open
Our results establish STIM1 as a crucial regulator for the maintenance of the intestinal barrier during colitis and provide a potential target for IBD treatment.
View article: B3galt5 Deficiency Attenuates Hepatocellular Carcinoma by Suppressing mTOR/p70s6k-Mediated Glycolysis
B3galt5 Deficiency Attenuates Hepatocellular Carcinoma by Suppressing mTOR/p70s6k-Mediated Glycolysis Open
Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies with high morbidity and mortality. Beta-1,3-galactosyltransferase 5 (b3galt5) plays crucial roles in protein glycosylation, but its function in HCC remains u…
View article: Gene Expression Profiling for the Diagnosis of Multiple Primary Malignant Tumors
Gene Expression Profiling for the Diagnosis of Multiple Primary Malignant Tumors Open
Background: The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and increased aging of the population. For patients with a prior cancer histo…
View article: More realistic low-resolution OCT image generation approach for training deep neural networks
More realistic low-resolution OCT image generation approach for training deep neural networks Open
Super-resolution image reconstruction has become a hot topic with the development of deep learning methods, which have been applied in medical images and shown its great potential application. The available simple and uniform bicubic inter…
View article: [Retracted] p53 suppresses stress‑induced cellular senescence via regulation of autophagy under the deprivation of serum
[Retracted] p53 suppresses stress‑induced cellular senescence via regulation of autophagy under the deprivation of serum Open
Following the publication of this article, an interested reader drew to the Editor's attention that certain GAPDH control bands were strikingly similar, comparing between two different figures in the paper. Two GAPDH bands in Fig. 1D appea…
View article: Gene Expression Profiling For Diagnosis of Multiple Primary Malignant Tumors
Gene Expression Profiling For Diagnosis of Multiple Primary Malignant Tumors Open
Background: The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and the increased aging of the population. For patients with a prior cancer h…
View article: Axial Super-Resolution Study for Optical Coherence Tomography Images Via Deep Learning
Axial Super-Resolution Study for Optical Coherence Tomography Images Via Deep Learning Open
Optical coherence tomography (OCT) is a noninvasive, high resolution, and real-time imaging technology that has been used in ophthalmology and other medical fields. Limited by the point spread function of OCT system, it is difficult to opt…