Hong Du
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View article: Algorithmic Governance for Health Information: A Quality Assessment of Pulmonary Nodule Videos on Bilibili and TikTok with Policy Implications (Preprint)
Algorithmic Governance for Health Information: A Quality Assessment of Pulmonary Nodule Videos on Bilibili and TikTok with Policy Implications (Preprint) Open
BACKGROUND With the increasing use of low-dose computed tomography (LDCT), pulmonary nodules are more frequently detected, raising concerns about early-stage lung cancer. Short-video platforms such as TikTok and Bilibili have become impor…
View article: Case Report: Durable complete response to antigen-specific cytotoxic T lymphocyte therapy in advanced EGFR-TKI resistant lung adenocarcinoma: a case of adoptive cellular immunotherapy overcoming acquired targeted resistance
Case Report: Durable complete response to antigen-specific cytotoxic T lymphocyte therapy in advanced EGFR-TKI resistant lung adenocarcinoma: a case of adoptive cellular immunotherapy overcoming acquired targeted resistance Open
Adoptive cell therapy (ACT), an important component of tumor immunotherapy, achieves precise anti-cancer effects by reinfusing in vitro -processed immune cells, providing a new option for advanced tumor patients with resistance to chemothe…
View article: PC3D-YOLO: An Enhanced Multi-Scale Network for Crack Detection in Precast Concrete Components
PC3D-YOLO: An Enhanced Multi-Scale Network for Crack Detection in Precast Concrete Components Open
Crack detection in precast concrete components aims to achieve precise extraction of crack features within complex image backgrounds. Current computer vision-based methods typically conduct limited local searches at a single scale, constra…
View article: Hantaan virus activates Src family kinase and induces endothelial cell hyperpermeability via the TLR4/TRAF6 pathway
Hantaan virus activates Src family kinase and induces endothelial cell hyperpermeability via the TLR4/TRAF6 pathway Open
Introduction. Hantaan virus (HTNV) predominantly infects human vascular endothelial cells (ECs) and causes increased vascular permeability, triggering haemorrhagic fever with renal syndrome, mainly in Asia. Previous studies have shown that…
View article: Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors
Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors Open
While CAR-T therapy has revolutionized the treatment of some hematological malignancies, significant hurdles remain in extending its success to solid tumors. Continued research efforts focusing on improving CAR-T cell efficacy, safety, and…
View article: Comparison of clinical efficacy and secondary infections between conventional-dose and high-dose glucocorticoid in hemorrhagic fever with renal syndrome: a dual-center retrospective cohort study
Comparison of clinical efficacy and secondary infections between conventional-dose and high-dose glucocorticoid in hemorrhagic fever with renal syndrome: a dual-center retrospective cohort study Open
High-dose GC show no superiority over conventional-dose GC on hospital stay, acute-phase fluid requirement, renal replacement rates, mechanical ventilation needs, severe hemorrhagic complications, or mortality. High-dose GC may increase se…
View article: Retraction Note: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p
Retraction Note: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p Open
View article: A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer
A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer Open
Precision treatment of gastric cancer requires specific biomarkers, and CLDN18.2 emerges as a promising target for patients’ stratification and therapeutic guidance. In 563 cases, 54.4% of patients are identified as CLDN18.2‐positive, with…
View article: Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms
Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms Open
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by injury to steatotic hepatocytes that triggers the release of endogenous danger-associated molecular patterns. Recent work demonstrated that exposed lipid droplets …
View article: Biomass Models, Allometric Relationships, and Carbon Sink Of Sargassum Henslowianum In Nan'Ao Island
Biomass Models, Allometric Relationships, and Carbon Sink Of Sargassum Henslowianum In Nan'Ao Island Open
View article: Engineered macrophages: an “Intelligent Repair” cellular machine for heart injury
Engineered macrophages: an “Intelligent Repair” cellular machine for heart injury Open
Macrophages are crucial in the heart’s development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditi…
View article: Correction: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p
Correction: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p Open
View article: The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling
The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling Open
Background Ubiquitin-specific protease 15 (USP15) exhibits amplifications in various tumors, including gastric cancer (GC), yet its biological function and mechanisms in GC progression remain elusive. Methods Here, we established stable US…
View article: Super-enhancer-associated LINC00963 promotes epithelial-mesenchymal transition in gastric cancer
Super-enhancer-associated LINC00963 promotes epithelial-mesenchymal transition in gastric cancer Open
Background In clinical practice, gastric cancer (GC) is a common malignancy with high morbidity. Accumulating research has revealed that lncRNAs are involved in the development and metastasis of tumor tissues in multiple cancers. As report…
View article: Death receptor 5 promotes tumor progression in gastric cancer
Death receptor 5 promotes tumor progression in gastric cancer Open
Death receptor 5 (DR5) can inhibit malignant proliferation via tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐induced apoptosis in many cancers. Here we examined the expression and sublocalization of DR5 in gastric cancer,…
View article: Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction
Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction Open
View article: TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance
TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance Open
Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy. Herein, using the CRI…
View article: Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer
Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer Open
Neoadjuvant chemotherapy (NACT) has been established as being an effective treatment for advanced gastric cancer (GC), while the predictive biomarker of NACT efficacy remains under investigation. Aspartate β-hydroxylase (ASPH) represents a…
View article: CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum
CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum Open
[This corrects the article DOI: 10.7150/ijbs.57826.].
View article: Intratumor heterogeneity and clonal distribution of tumor-infiltrating lymphocytes revealed by multiregional T and B cell receptor repertoires in gastric cancer
Intratumor heterogeneity and clonal distribution of tumor-infiltrating lymphocytes revealed by multiregional T and B cell receptor repertoires in gastric cancer Open
Tumor-infiltrating lymphocytes (TILs) recognizing tumor neoantigens can be harnessed as a better prognosis for several human tumors. T and B cell receptor (TCR and BCR) repertoires are the key elements served as tags to track TILs in tumor…
View article: SDCBP‐AS1 destabilizes β‐catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis
SDCBP‐AS1 destabilizes β‐catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis Open
Background Gastric cancer (GC) is among the most malignant tumors, yet the pathogenesis is not fully understood, especially the lack of detailed information about the mechanisms underlying long non‐coding RNA (lncRNA)‐mediated post‐transla…
View article: Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis
Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis Open
Background The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment of advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation and identify …
View article: Novel prognostic marker LINC00205 promotes tumorigenesis and metastasis by competitively suppressing miRNA-26a in gastric cancer
Novel prognostic marker LINC00205 promotes tumorigenesis and metastasis by competitively suppressing miRNA-26a in gastric cancer Open
View article: SNHG16 lncRNAs are overexpressed and may be oncogenic in human gastric cancer by regulating cell cycle progression
SNHG16 lncRNAs are overexpressed and may be oncogenic in human gastric cancer by regulating cell cycle progression Open
The small nucleolar RNA host gene 16 (SNHG16) has recently been shown to be a putative oncogene in gastric cancer (GC) and other cancer types, but how its four lncRNA variants are expressed in any physiological and pathological situation r…
View article: Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4 Open
Background Insulin gene enhancer protein 1, (ISL1), a LIM‐homeodomain transcription factor, is involved in multiple tumors and is associated with insulin secretion and metabolic phenotypes. However, the role of ISL1 in stimulating glycolys…
View article: CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways
CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways Open
Abnormal expression of CXC motif chemokine ligand 16 (CXCL16) has been demonstrated to be associated with tumor progression and metastasis, served as a prognostic factor in many cancers, with higher relative expression behaving as a marker…
View article: Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion
Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion Open
Significance Postoperative peritoneal adhesions are frequent complications for almost any types of abdominal and pelvic surgery and lead to numerous medical problems. Current antiadhesion solutions include pharmacological treatment and phy…
View article: TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer
TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer Open
View article: An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer
An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer Open
The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for gastric cancer (GC) patients and complementary factors are in urgent need. Here we aimed to develop a comprehensive model, consisting of both imm…
View article: TNFRSF11B activates Wnt/β-catenin signaling and promotes gastric cancer progression
TNFRSF11B activates Wnt/β-catenin signaling and promotes gastric cancer progression Open
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to be involved in the development and progression of several human malignancies. However, little is unveiled regarding the complex mechanisms of TNFRSF11B i…